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Contents Volume 17 Issue 9 September 15, 2025

Editorial

Associations among healthcare insurance, tumor-node-metastasis stage and cancer survival: More to be understood

Zhuo-Yu Li, Rui Wang, Xin-Zu Chen, SIGES Research Group

World J Gastrointest Oncol 17(9):106116. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.106116

Abstract (76) | Core Tip (86) | Full Article (HTML) (216) | Figures (1-1) (61) | Tables (1-1) (64) | Full Article (PDF)-430K (53) | Full Article with Cover (PDF)-762K (41) | Full Article (XML)-49K (33) | Audio-1180K (13) | Peer-Review Report-268K (36) | Answering Reviewers-166K (28) | Received: 02/16/2025 | Revised: 05/26/2025 | Accepted: 08/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (1719) | Similar Articles (108) | Timeline of Article Publication (6) | Article Quality Tracking (0) | Cite |

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Changing patterns of cholangiocarcinoma and gallbladder cancer: A regional perspective from Northeastern Italy

Sevgi Kalkanli Tas, Ayse Naz Ozabaci, Duygu Kirkik

World J Gastrointest Oncol 17(9):108578. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.108578

Abstract (80) | Core Tip (79) | Full Article (HTML) (337) | Figures (1-2) (65) | Tables (1-1) (63) | Full Article (PDF)-1749K (97) | Full Article with Cover (PDF)-2078K (51) | Full Article (XML)-71K (41) | Audio-591K (29) | Peer-Review Report-302K (52) | Answering Reviewers-151K (28) | Supplementary Material-410K (49) | Received: 04/17/2025 | Revised: 05/22/2025 | Accepted: 07/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1995) | Similar Articles (219) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Missing link: Viral RNA signatures in circulating exosomes as early diagnostic biomarkers for gastrointestinal cancers

Mahmoud Darweesh, Saeed Mohammadi

World J Gastrointest Oncol 17(9):110110. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110110

Abstract (79) | Core Tip (88) | Full Article (HTML) (264) | Tables (1-1) (71) | Full Article (PDF)-409K (46) | Full Article with Cover (PDF)-738K (40) | Full Article (XML)-79K (41) | Audio-545K (24) | Peer-Review Report-271K (34) | Answering Reviewers-124K (33) | Received: 05/29/2025 | Revised: 07/02/2025 | Accepted: 08/13/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1703) | Similar Articles (214) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Review

Fibroblast growth factor 19-fibroblast growth factor receptor 4 axis: From oncogenesis to targeted-immunotherapy in advanced hepatocellular carcinoma

Tian-Ao Zhan, Feng Xia, Hong-Wei Huang, Jun-Cheng Zhan, Xin-Kang Liu, Qi Cheng

World J Gastrointest Oncol 17(9):108649. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.108649

Abstract (79) | Core Tip (88) | Full Article (HTML) (482) | Figures (1-2) (83) | Tables (1-3) (91) | Full Article (PDF)-1553K (156) | Full Article with Cover (PDF)-1881K (52) | Full Article (XML)-369K (48) | Audio-984K (35) | Peer-Review Report-301K (31) | Answering Reviewers-400K (34) | Received: 04/19/2025 | Revised: 05/25/2025 | Accepted: 07/18/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (2101) | Similar Articles (1878) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Endoscopic management of pancreatic cystic neoplasms

Yan Zeng, Jun-Wen Zhang, Jian Yang

World J Gastrointest Oncol 17(9):110376. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110376

Abstract (75) | Core Tip (96) | Full Article (HTML) (299) | Figures (1-7) (79) | Full Article (PDF)-56146K (71) | Full Article with Cover (PDF)-56475K (120) | Full Article (XML)-234K (40) | Audio-1635K (27) | Peer-Review Report-198K (34) | Answering Reviewers-248K (50) | Received: 06/04/2025 | Revised: 06/15/2025 | Accepted: 08/13/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1807) | Similar Articles (13) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Minireviews

Status quo of hypercoagulation as a prognostic indicator following neoadjuvant immunochemotherapy in locally advanced gastric cancer

Grigorios Christodoulidis, Dimitra Bartzi, Kyriaki Tsagkidou, Konstantinos Eleftherios Koumarelas, Dimitrios Zacharoulis

World J Gastrointest Oncol 17(9):106868. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.106868

Abstract (70) | Core Tip (95) | Full Article (HTML) (211) | Tables (1-2) (62) | Full Article (PDF)-441K (58) | Full Article with Cover (PDF)-769K (46) | Full Article (XML)-114K (39) | Audio-725K (27) | Peer-Review Report-230K (25) | Answering Reviewers-63K (29) | Received: 03/09/2025 | Revised: 04/01/2025 | Accepted: 07/28/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2551) | Similar Articles (1285) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Immune checkpoint molecules signal regulatory protein alpha in the development of hepatocellular carcinoma

Xue Zhang, Dong-Bo Chen, Rui Zhang, Pu Chen, Shao-Ping She, Hong-Song Chen, Li-Ying Ren, Yao Yang

World J Gastrointest Oncol 17(9):109824. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.109824

Abstract (78) | Core Tip (88) | Full Article (HTML) (228) | Figures (1-3) (76) | Tables (1-1) (73) | Full Article (PDF)-3654K (54) | Full Article with Cover (PDF)-3983K (39) | Full Article (XML)-162K (36) | Audio-482K (34) | Peer-Review Report-262K (30) | Answering Reviewers-163K (44) | Received: 05/23/2025 | Revised: 06/29/2025 | Accepted: 07/30/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1517) | Similar Articles (1878) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Case Control Study

Untargeted metabolomics analysis of metabolite changes in gastric cancer patients from plateau regions

Ling-Hong Zhu, Zhao-Xin Jin, Yan-Qing Ma, Xiao Feng, Cai-Hong Ci, Yun-Song Zhou, Qiao-Ling Gu, Yong-Mei Lan, Zi-Long Zhang

World J Gastrointest Oncol 17(9):109777. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.109777

Abstract (82) | Core Tip (112) | Full Article (HTML) (239) | Figures (1-8) (90) | Tables (1-5) (71) | Full Article (PDF)-3466K (78) | Full Article with Cover (PDF)-3791K (61) | Full Article (XML)-120K (51) | Audio-583K (25) | Peer-Review Report-239K (34) | Answering Reviewers-48K (35) | Received: 05/23/2025 | Revised: 06/09/2025 | Accepted: 08/19/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (2110) | Similar Articles (1285) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Retrospective Cohort Study

Efficacy and safety of transarterial chemoembolization with chemotherapy, PD-1/PD-L1 inhibitors, and tyrosine kinase inhibitors in unresectable intrahepatic cholangiocarcinoma

Xiao Chen, Xi-Heng Sun, Yue Xiao, Dan Zhang, Xiao-Yan Lu, Cheng-Lei Fu, Chun Bi, Xia Wang

World J Gastrointest Oncol 17(9):103816. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.103816

Abstract (92) | Core Tip (79) | Full Article (HTML) (281) | Figures (1-1) (71) | Tables (1-3) (66) | Full Article (PDF)-688K (52) | Full Article with Cover (PDF)-1018K (39) | Full Article (XML)-102K (51) | Audio-755K (22) | Peer-Review Report-202K (30) | Answering Reviewers-148K (39) | Received: 01/04/2025 | Revised: 06/29/2025 | Accepted: 08/01/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (1946) | Similar Articles (213) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (1) | Cite |

(0) | (0) | (0) | (0) | Open

Construction of a risk prediction model for early postoperative recurrence in stage II/III colorectal cancer

Feng-Chun Xiong, Ming-Peng Luo, Shan-Ming Ruan

World J Gastrointest Oncol 17(9):107968. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.107968

Abstract (74) | Core Tip (79) | Full Article (HTML) (264) | Figures (1-5) (69) | Tables (1-2) (72) | Full Article (PDF)-2443K (89) | Full Article with Cover (PDF)-2771K (49) | Full Article (XML)-143K (34) | Audio-187K (19) | Peer-Review Report-323K (28) | Answering Reviewers-122K (39) | Supplementary Material-106K (25) | Received: 04/01/2025 | Revised: 05/26/2025 | Accepted: 08/01/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2326) | Similar Articles (1306) | Timeline of Article Publication (3) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Efficacy of adjuvant chemotherapy in stage II colon cancer patients with twelve or more lymph nodes retrieve

Yu Huo, Yue-Yang Zhang, Shuai Jiao, Zhong-Yuan Bai, Wen-Qi Bai, Hai-Tao Zhou, Xu Guan

World J Gastrointest Oncol 17(9):108470. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.108470

Abstract (83) | Core Tip (84) | Full Article (HTML) (219) | Figures (1-3) (77) | Tables (1-3) (67) | Full Article (PDF)-2251K (61) | Full Article with Cover (PDF)-2582K (27) | Full Article (XML)-88K (37) | Audio-2368K (27) | Peer-Review Report-237K (26) | Answering Reviewers-122K (37) | Supplementary Material-71K (36) | Received: 04/14/2025 | Revised: 05/26/2025 | Accepted: 07/25/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2107) | Similar Articles (373) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Medical travel patterns for hepatocellular carcinoma treatment in South Korea: National Health Insurance data from 2013 to 2021

Sungmin Kim, Naeun Kim, Hyung-Sik Lee, Mina Kim, Hoseob Kim, Youngmin Choi

World J Gastrointest Oncol 17(9):109060. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.109060

Abstract (87) | Core Tip (87) | Full Article (HTML) (212) | Figures (1-4) (67) | Tables (1-2) (68) | Full Article (PDF)-18948K (63) | Full Article with Cover (PDF)-19277K (51) | Full Article (XML)-105K (36) | Audio-647K (38) | Peer-Review Report-307K (30) | Answering Reviewers-209K (40) | Received: 04/29/2025 | Revised: 06/07/2025 | Accepted: 07/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (3209) | Similar Articles (1878) | Timeline of Article Publication (2) | Article Quality Tracking (0) | Cite |

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Prognostic factors and efficacy of postoperative chemotherapy in patients with gastric cancer with positive peritoneal cytology after gastrectomy

Yoichi Sugiyama, Kazuaki Tanabe, Senichiro Yanagawa, Hirofumi Tazawa, Kazuhiro Toyota, Mikihiro Kano, Toshihiro Misumi, Masayuki Shishida, Keisuke Okano, Ryuichi Hotta, Hiroshi Ota, Yasuhiro Imaoka, Toshikatsu Fukuda, Shinya Takahashi, Hideki Ohdan

World J Gastrointest Oncol 17(9):110245. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110245

Abstract (89) | Core Tip (99) | Full Article (HTML) (272) | Figures (1-3) (72) | Tables (1-5) (70) | Full Article (PDF)-22435K (84) | Full Article with Cover (PDF)-22766K (49) | Full Article (XML)-157K (37) | Audio-238K (12) | Peer-Review Report-267K (47) | Answering Reviewers-172K (43) | Received: 06/02/2025 | Revised: 06/24/2025 | Accepted: 07/24/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2101) | Similar Articles (1465) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Retrospective Study

Comparative impact of antiviral therapies on postoperative recurrence risk in patients with hepatitis B virus-related hepatocellular carcinoma

Hua-Mei Liu, Xin Zhang, Hang-Ying Huang, Jia-Min Sun, Qing-Dong Tong

World J Gastrointest Oncol 17(9):106297. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.106297

Abstract (86) | Core Tip (90) | Full Article (HTML) (262) | Figures (1-2) (60) | Tables (1-1) (63) | Full Article (PDF)-538K (48) | Full Article with Cover (PDF)-868K (37) | Full Article (XML)-68K (53) | Audio-803K (26) | Peer-Review Report-233K (32) | Answering Reviewers-77K (26) | Received: 03/21/2025 | Revised: 04/15/2025 | Accepted: 07/30/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1871) | Similar Articles (2241) | Timeline of Article Publication (0) | Article Quality Tracking (1) | Cite |

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Study of serum tumor markers in the early diagnosis of pancreatic cancer

Qian-Xi Deng, Xue-Li Tang, Guo-Jun Yuan, Qin Jian, Xian-Hong Chen, Lin-Ju Wu

World J Gastrointest Oncol 17(9):106910. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.106910

Abstract (82) | Core Tip (80) | Full Article (HTML) (444) | Figures (1-1) (62) | Tables (1-5) (73) | Full Article (PDF)-16795K (100) | Full Article with Cover (PDF)-17121K (57) | Full Article (XML)-96K (61) | Audio-1175K (32) | Peer-Review Report-243K (56) | Answering Reviewers-57K (37) | Received: 04/30/2025 | Revised: 06/03/2025 | Accepted: 07/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2203) | Similar Articles (449) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Investigation of gastrointestinal tumor symptoms and risk factors in eighty patients with Parkinson’s disease

Zhong-Guo Fu, Zhan-Xiu Ren, Xin-Hong Wang, Bai-Fang Wang

World J Gastrointest Oncol 17(9):106912. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.106912

Abstract (72) | Core Tip (85) | Full Article (HTML) (177) | Tables (1-5) (61) | Full Article (PDF)-417K (48) | Full Article with Cover (PDF)-744K (44) | Full Article (XML)-72K (48) | Audio-327K (26) | Peer-Review Report-239K (28) | Answering Reviewers-237K (32) | Received: 05/09/2025 | Revised: 06/06/2025 | Accepted: 08/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1768) | Similar Articles (254) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Correlation between sarcopenia diagnosed by C3SMI criteria and prognosis in esophageal cancer patients after radiotherapy

De-En Wang, Xiao-Fang Qin, Wei Yang

World J Gastrointest Oncol 17(9):107626. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.107626

Abstract (81) | Core Tip (76) | Full Article (HTML) (170) | Figures (1-1) (62) | Tables (1-4) (68) | Full Article (PDF)-504K (44) | Full Article with Cover (PDF)-832K (31) | Full Article (XML)-125K (44) | Audio-567K (21) | Peer-Review Report-236K (24) | Answering Reviewers-199K (26) | Received: 04/22/2025 | Revised: 05/25/2025 | Accepted: 07/30/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1704) | Similar Articles (300) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Correlation between perineural invasion and clinicopathological characteristics in pancreatic cancer

Xiao-Liang Lu, Chuang Ge, Ruo-Chen Wang, Hong Zang

World J Gastrointest Oncol 17(9):108277. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.108277

Abstract (95) | Core Tip (87) | Full Article (HTML) (261) | Figures (1-2) (66) | Tables (1-4) (67) | Full Article (PDF)-766K (95) | Full Article with Cover (PDF)-1096K (64) | Full Article (XML)-91K (44) | Audio-963K (21) | Peer-Review Report-294K (27) | Answering Reviewers-84K (28) | Received: 04/09/2025 | Revised: 06/04/2025 | Accepted: 07/18/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1983) | Similar Articles (459) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Chemotherapy plus bevacizumab vs chemoimmunotherapy for metastatic colorectal cancer: Real-world analysis

Zhao Gao, Zheng-Fei Zhou, Xiao-Yan Wang, Tao Song, Shi-Kai Wu, Xuan Jin

World J Gastrointest Oncol 17(9):109949. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.109949

Abstract (89) | Core Tip (86) | Full Article (HTML) (260) | Figures (1-5) (80) | Tables (1-5) (72) | Full Article (PDF)-49886K (100) | Full Article with Cover (PDF)-50215K (48) | Full Article (XML)-115K (46) | Audio-258K (25) | Peer-Review Report-244K (34) | Answering Reviewers-446K (38) | Received: 05/26/2025 | Revised: 06/23/2025 | Accepted: 08/06/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1936) | Similar Articles (44) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Observational Study

Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer

Jun-Wen Huang, Chen Lin, Chen-Jia Lu, Hua-Shou Wang, Dan-Dan Zou

World J Gastrointest Oncol 17(9):110981. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110981

Abstract (78) | Core Tip (78) | Full Article (HTML) (228) | Figures (1-3) (63) | Tables (1-4) (65) | Full Article (PDF)-1177K (50) | Full Article with Cover (PDF)-1506K (32) | Full Article (XML)-84K (42) | Audio-196K (25) | Peer-Review Report-203K (35) | Answering Reviewers-114K (31) | Received: 06/19/2025 | Revised: 07/02/2025 | Accepted: 07/31/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (3410) | Similar Articles (1305) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Basic Study

Correlation between KAT6A and PD-L1 expression and role of KAT6A in colorectal cancer

Zhen-Dong Zhou, Jian-Pei Zhao, Shu-Chun Zheng, Ting-Ting Wang

World J Gastrointest Oncol 17(9):105937. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.105937

Abstract (89) | Core Tip (77) | Full Article (HTML) (241) | Figures (1-6) (75) | Full Article (PDF)-30483K (65) | Full Article with Cover (PDF)-30811K (38) | Full Article (XML)-98K (71) | Audio-126K (13) | Peer-Review Report-229K (32) | Answering Reviewers-121K (47) | Received: 02/10/2025 | Revised: 03/31/2025 | Accepted: 08/12/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1971) | Similar Articles (1144) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Relationship between uric acid and colon cancer risk: Dose-response analysis and mechanisms

Teng-Fei Sun, Ke-Xin Fan, Yu-Xin Luo, Jia Song, Zhuo-Xiao Han, Xiao-Lan Zhang

World J Gastrointest Oncol 17(9):107651. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.107651

Abstract (88) | Core Tip (89) | Full Article (HTML) (377) | Figures (1-6) (69) | Tables (1-3) (68) | Full Article (PDF)-29106K (53) | Full Article with Cover (PDF)-29432K (40) | Full Article (XML)-120K (48) | Audio-626K (42) | Peer-Review Report-305K (29) | Answering Reviewers-195K (34) | Received: 03/27/2025 | Revised: 05/03/2025 | Accepted: 06/30/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1926) | Similar Articles (204) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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DEAD/H-box RNA helicase 10 promotes pancreatic cancer cell proliferation via ribonucleotide reductase M2

Zhi-Sheng Qiu, Xiao-Chun Wang, Ji-Chun Ma, Cheng-Lou Zhu, Yong-Li Hu, Ming-Xu Da

World J Gastrointest Oncol 17(9):108672. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.108672

Abstract (72) | Core Tip (78) | Full Article (HTML) (257) | Figures (1-8) (80) | Full Article (PDF)-15045K (58) | Full Article with Cover (PDF)-15374K (55) | Full Article (XML)-97K (40) | Audio-550K (30) | Peer-Review Report-265K (35) | Answering Reviewers-1330K (42) | Supplementary Material-223K (40) | Received: 04/19/2025 | Revised: 05/23/2025 | Accepted: 07/18/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (3113) | Similar Articles (64) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates Rap1 signaling

Yi-Jia Chen, Cheng Peng, Li-Wei Wang, Jia-Xin Chai, Jian-Dong Wang, Qi-Bin He

World J Gastrointest Oncol 17(9):108760. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.108760

Abstract (75) | Core Tip (89) | Full Article (HTML) (213) | Figures (1-6) (70) | Tables (1-3) (70) | Full Article (PDF)-134443K (43) | Full Article with Cover (PDF)-134771K (29) | Full Article (XML)-130K (36) | Audio-494K (22) | Peer-Review Report-255K (30) | Answering Reviewers-123K (41) | Supplementary Material-148K (29) | Received: 04/23/2025 | Revised: 06/13/2025 | Accepted: 07/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1786) | Similar Articles (1291) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Ginsenoside F4 inhibits colorectal cancer progression by boosting dendritic cell maturation and remodeling the tumor microenvironment

Wei Xie, Xue-Jian Li, Yu-Sen Zhong, Jie Fang, Hui Qi, Meng Yang, Hua-Zhong Ying, Chen-Huan Yu

World J Gastrointest Oncol 17(9):108892. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.108892

Abstract (80) | Core Tip (98) | Full Article (HTML) (345) | Figures (1-8) (71) | Tables (1-1) (64) | Full Article (PDF)-12092K (85) | Full Article with Cover (PDF)-12421K (69) | Full Article (XML)-152K (39) | Audio-971K (25) | Peer-Review Report-202K (29) | Answering Reviewers-96K (39) | Received: 04/25/2025 | Revised: 06/04/2025 | Accepted: 07/14/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1995) | Similar Articles (1162) | Timeline of Article Publication (2) | Article Quality Tracking (0) | Cite |

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Quantitative immunohistochemistry analysis of pancreatic adenocarcinoma upregulated factor expression in pancreatic cancer and its prognostic significance

Jae Hyeong Kim, Hee Young Na, Kwangrok Jung, Dayeon Jang, Yuna Youn, Dae Hwan Kim, Hee Dong Han, Jin-Hyeok Hwang

World J Gastrointest Oncol 17(9):109055. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.109055

Abstract (91) | Core Tip (98) | Full Article (HTML) (345) | Figures (1-4) (69) | Tables (1-4) (66) | Full Article (PDF)-13499K (64) | Full Article with Cover (PDF)-13829K (80) | Full Article (XML)-101K (39) | Audio-970K (36) | Peer-Review Report-204K (29) | Answering Reviewers-385K (36) | Received: 05/08/2025 | Revised: 07/04/2025 | Accepted: 08/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (1929) | Similar Articles (9) | Timeline of Article Publication (0) | Authors Evaluation (2) | Article Quality Tracking (0) | Cite |

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Methionyl-tRNA synthetase 1 participates in hepatocellular carcinoma and its regulated gene profile possesses potent prognostic ability

Hai-Yan Bu, Hong Huang, Jia Li, Ze-Bing Huang, Yan Huang, Yu-Kun Huang, Ai-Min Wang, Li Wu, Jiao Yuan, Rong-Jun Wang, Min Lu, Song-Man Yu, Pan-Pan Yi, Ya-Yu Chen, Yu-Peng Jiang, Xing-Wang Hu

World J Gastrointest Oncol 17(9):109127. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.109127

Abstract (70) | Core Tip (83) | Full Article (HTML) (223) | Figures (1-10) (75) | Full Article (PDF)-20322K (58) | Full Article with Cover (PDF)-20650K (75) | Full Article (XML)-160K (46) | Audio-632K (39) | Peer-Review Report-276K (25) | Answering Reviewers-95K (28) | Received: 05/09/2025 | Revised: 06/06/2025 | Accepted: 07/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2937) | Similar Articles (1878) | Timeline of Article Publication (4) | Article Quality Tracking (0) | Cite |

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Rapamycin suppresses small bowel adenocarcinoma HUTU 80 cells proliferation by inhibiting hypoxia-inducible factor-1α mediated metabolic reprogramming

Bao-Peng Pu, Peng-Hui Wang, Kai-Kai Guo, Chun Liu, Si-Run Chen, Xiao-Meng Li, Shi-Min Chen, Xiang-Zhou Zeng, Chang Gao

World J Gastrointest Oncol 17(9):109378. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.109378

Abstract (80) | Core Tip (86) | Full Article (HTML) (291) | Figures (1-8) (74) | Tables (1-1) (64) | Full Article (PDF)-23345K (95) | Full Article with Cover (PDF)-23673K (40) | Full Article (XML)-189K (42) | Audio-461K (11) | Peer-Review Report-280K (31) | Answering Reviewers-280K (32) | Supplementary Material-47K (35) | Received: 05/08/2025 | Revised: 06/20/2025 | Accepted: 08/18/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1966) | Similar Articles (20) | Timeline of Article Publication (0) | Authors Evaluation (2) | Article Quality Tracking (0) | Cite |

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Irreversible electroporation combined with checkpoint blockade stimulates antitumor immune response in a hepatocellular carcinoma mouse model

Yan-Li Xing, Hong-Mei Li, Xiao-Ming Pang, Ying Zhang, Ting Yang, Yan-Hong Li, De-Chuan Liu, Yang-Yang Ma, Li-Zhi Niu

World J Gastrointest Oncol 17(9):110166. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110166

Abstract (81) | Core Tip (83) | Full Article (HTML) (296) | Figures (1-4) (61) | Full Article (PDF)-25359K (58) | Full Article with Cover (PDF)-25688K (63) | Full Article (XML)-87K (50) | Audio-267K (39) | Peer-Review Report-262K (39) | Answering Reviewers-75K (35) | Received: 05/30/2025 | Revised: 07/05/2025 | Accepted: 08/15/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (2171) | Similar Articles (1890) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Transcription factor 3 enhances hepatocellular carcinoma metastasis by upregulating matrix metalloproteinase-11

Hong-Peng Tian, Tian-Hao Wu, Guang-Jun Zhang, Sheng-Jie Li

World J Gastrointest Oncol 17(9):110527. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110527

Abstract (76) | Core Tip (74) | Full Article (HTML) (173) | Figures (1-5) (83) | Tables (1-4) (62) | Full Article (PDF)-10707K (83) | Full Article with Cover (PDF)-11035K (44) | Full Article (XML)-109K (63) | Audio-1643K (18) | Peer-Review Report-224K (28) | Answering Reviewers-91K (35) | Supplementary Material-298K (33) | Received: 06/08/2025 | Revised: 07/06/2025 | Accepted: 08/06/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2236) | Similar Articles (1878) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Case Report

Rapid cholestasis improvement as key strategy for steroid-refractory immune-related cholangitis: A case report

Zhao Gao, Ji-Xin Zhang, Xiao-Dong Tian, Shi-Kai Wu, Xuan Jin

World J Gastrointest Oncol 17(9):108960. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.108960

Abstract (72) | Core Tip (75) | Full Article (HTML) (265) | Figures (1-6) (62) | Full Article (PDF)-10024K (71) | Full Article with Cover (PDF)-10355K (63) | Full Article (XML)-47K (43) | Audio-121K (25) | Peer-Review Report-273K (39) | Answering Reviewers-178K (32) | Received: 04/26/2025 | Revised: 06/16/2025 | Accepted: 08/07/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1760) | Similar Articles (4547) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Misdiagnosis of gastric oxyntic gland adenoma as hyperplastic polyp: A case report

Rui-Xiang Xue, Xin-Yu Lu, Pei Deng, Lin-Heng Wang, Yi-Fei Yun

World J Gastrointest Oncol 17(9):110505. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110505

Abstract (72) | Core Tip (86) | Full Article (HTML) (315) | Figures (1-3) (61) | Full Article (PDF)-9754K (76) | Full Article with Cover (PDF)-10082K (54) | Full Article (XML)-55K (48) | Audio-457K (26) | Peer-Review Report-210K (26) | Answering Reviewers-212K (39) | Received: 06/07/2025 | Revised: 07/22/2025 | Accepted: 08/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1984) | Similar Articles (4558) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Letter to the Editor

Importance of the pattern of lymph node metastasis in upper and lower gastric cancer

Parbatraj Regmi, Sagar Mani Regmi, Anish Paudyal

World J Gastrointest Oncol 17(9):103144. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.103144

Abstract (93) | Core Tip (89) | Full Article (HTML) (267) | Full Article (PDF)-345K (62) | Full Article with Cover (PDF)-677K (56) | Full Article (XML)-26K (35) | Audio-295K (9) | Peer-Review Report-185K (27) | Answering Reviewers-139K (31) | Received: 11/10/2024 | Revised: 03/22/2025 | Accepted: 04/10/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1538) | Similar Articles (1379) | Timeline of Article Publication (1) | Article Quality Tracking (1) | Cite |

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Utility of inflammatory markers as predictors of recurrence in gastrointestinal stromal tumors: Insights from a nomogram-based approach

Chris B Lamprecht, Tyler Kashuv, Brandon Lucke-Wold

World J Gastrointest Oncol 17(9):103702. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.103702

Abstract (87) | Core Tip (92) | Full Article (HTML) (389) | Full Article (PDF)-385K (65) | Full Article with Cover (PDF)-714K (79) | Full Article (XML)-66K (41) | Audio-757K (9) | Peer-Review Report-171K (29) | Answering Reviewers-102K (29) | Received: 11/27/2024 | Revised: 04/03/2025 | Accepted: 04/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1510) | Similar Articles (79) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Local excision in rectal cancer: When and for whom?

Semra Demirli Atici, Aras Emre Canda, Mustafa Cem Terzi

World J Gastrointest Oncol 17(9):106146. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.106146

Abstract (81) | Core Tip (74) | Full Article (HTML) (258) | Full Article (PDF)-360K (73) | Full Article with Cover (PDF)-690K (96) | Full Article (XML)-50K (45) | Audio-310K (8) | Peer-Review Report-310K (40) | Answering Reviewers-107K (33) | Received: 02/16/2025 | Revised: 04/07/2025 | Accepted: 04/17/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1598) | Similar Articles (241) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Postoperative immune checkpoint inhibitors plus anti-angiogenesis for hepatitis B virus-associated hepatocellular carcinoma: Analyzing the evidence and future prospects

Arunkumar Krishnan, Diptasree Mukherjee

World J Gastrointest Oncol 17(9):106801. Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.106801

Abstract (72) | Core Tip (78) | Full Article (HTML) (171) | Full Article (PDF)-396K (60) | Full Article with Cover (PDF)-722K (49) | Full Article (XML)-64K (49) | Audio-268K (23) | Peer-Review Report-225K (36) | Answering Reviewers-66K (40) | Received: 03/06/2025 | Revised: 04/09/2025 | Accepted: 04/18/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1434) | Similar Articles (375) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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