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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2025; 17(9): 107651
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.107651
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.107651
Relationship between uric acid and colon cancer risk: Dose-response analysis and mechanisms
Teng-Fei Sun, Yu-Xin Luo, Jia Song, Xiao-Lan Zhang, Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Hebei Clinical Research Center for Digestive Diseases, Shijiazhuang 050000, Hebei Province, China
Teng-Fei Sun, Department of Gastroenterology, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, China
Ke-Xin Fan, Zhuo-Xiao Han, Department of Pulmonary and Critical Care Medicine, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, China
Author contributions: Sun TF was responsible for drafting the manuscript and analyzing the data; Sun TF and Fan KX conducted the majority of the experiments; Fan KX was responsible collecting the data; Fan KX and Han ZX contributed in statistical analysis; Luo YX provided a review and criticism of the statistical analysis; Song J provided interpretation of the data; Han ZX contributed in criticism of the design; Zhang XL was responsible for interpreting the results of the analysis, criticizing the statistical analysis, and revising the manuscript. All authors read and approved the final manuscript.
Institutional review board statement: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the First Hospital of Qinhuangdao, No. 2024W006-02.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Lan Zhang, Professor, Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Hebei Clinical Research Center for Digestive Diseases, No. 80 Huanghe Road, Yuhua District, Shijiazhuang 050000, Hebei Province, China.
Received: March 28, 2025
Revised: May 3, 2025
Accepted: June 30, 2025
Published online: September 15, 2025
Processing time: 172 Days and 7.7 Hours
Revised: May 3, 2025
Accepted: June 30, 2025
Published online: September 15, 2025
Processing time: 172 Days and 7.7 Hours
Core Tip
Core Tip: This study, encompassing 2020 colon cancer cases and 6060 controls, revealed an inverse association between uric acid levels and the risk of colon cancer. To delve deeper into the underlying mechanisms, we conducted in vitro experiments using colon cancer cells. Our findings demonstrated that uric acid potently inhibits cell proliferation and migration. Mechanistically, these effects were mediated by the induction of reactive oxygen species and the suppression of the phosphoinositide 3-kinases/protein kinase B/mammalian target of rapamycin signaling pathway.