Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer

doi:10.4251/wjgo.v17.i9.110981

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Sep 15, 2025 (publication date) through Sep 15, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Sep 15, 2025; 17(9): 110981
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110981

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Figure 1 Kaplan-Meier analysis comparing disease-free survival between gastrin-positive and gastrin-negative gastric cancer patients. No statistically significant difference was observed (hazard ratio = 1.516; 95% confidence interval: 0.895-2.570; P > 0.05). HR: Hazard ratio; CI: Confidence interval; GAS: Gastrin.

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Figure 2 Kaplan-Meier curve for overall survival Kaplan-Meier analysis comparing overall survival between gastrin-positive and gastrin-negative gastric cancer patients. Gastrin-positive patients showed significantly worse overall survival (hazard ratio = 2.717; 95% confidence interval: 1.311-5.633; P < 0.01). HR: Hazard ratio; CI: Confidence interval; GAS: Gastrin.

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Figure 3 Association between gastrin levels and Helicobacter pylori infection. H. pylori: Helicobacter pylori.

Citation: Huang JW, Lin C, Lu CJ, Wang HS, Zou DD. Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer. World J Gastrointest Oncol 2025; 17(9): 110981
URL: https://www.wjgnet.com/1948-5204/full/v17/i9/110981.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i9.110981