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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2025; 17(9): 110981
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110981
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110981
Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer
Jun-Wen Huang, Chen Lin, Chen-Jia Lu, Hua-Shou Wang, Dan-Dan Zou, Department of Pathology, People’s Hospital of Longhua District, Shenzhen 518110, Guangdong Province, China
Author contributions: Huang JW, Lu CJ, Wang HS, and Zou DD contributed to writing-review and editing; Huang JW, Lu CJ, and Zou DD wrote original draft; Wang HS and Zou DD contributed to data curation; Lin C and Zou DD contributed to methodology; Huang JW and Wang HS contributed to data analysis; Huang JW and Zou DD contributed to execution of experiments; Huang JW contributed to study design and formal analysis; Lin C contributed to conceptualization; Lu CJ contributed to literature research, investigation, and statistical analysis; Wang HS contributed to experimental studies. All authors approved the final version.
Institutional review board statement: This study was approved by Ethics Committee of People’s Hospital of Longhua District, No. 2025(063).
Informed consent statement: All of the patients had consented to research authorization for record review.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Individual participant data can be requested and accessed by contacting the study management teams of the studies upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chen Lin, Department of Pathology, People’s Hospital of Longhua District, No. 38 Jinglong Jianshe Road, Longhua District, Shenzhen 518110, Guangdong Pro
Received: June 20, 2025
Revised: July 2, 2025
Accepted: July 31, 2025
Published online: September 15, 2025
Processing time: 87 Days and 19.2 Hours
Revised: July 2, 2025
Accepted: July 31, 2025
Published online: September 15, 2025
Processing time: 87 Days and 19.2 Hours
Core Tip
Core Tip: This study explores the clinical relevance of serum gastrin and Helicobacter pylori (H. pylori) infection in gastric cancer. Among 226 patients, elevated serum gastrin, but not H. pylori status, was significantly associated with advanced tumor stage, lymphatic metastasis, and poor differentiation. Notably, gastrin-positive patients had worse overall survival. These findings suggest that hypergastrinemia may serve as a biomarker of tumor aggressiveness and prognosis in gastric cancer, offering potential targets for risk stratification and therapeutic intervention.