Correlation between perineural invasion and clinicopathological characteristics in pancreatic cancer

Table 1 General information and demographic characteristics of patients, n (%)

Items	Non-PNI group (n = 17)	PNI group (n = 65)	t	P value
Age (years), mean ± SD	60.42 ± 4.36	59.87 ± 3.25	0.485	0.633
Gender (male/female)	10 (58.82)/7(41.18)	33 (50.77)/32 (49.23)	0.102	0.749
BMI (kg/cm2), mean ± SD	25.64 ± 2.98	24.85 ± 2.67	0.987	0.334
Course of disease (months), mean ± SD	5.46 ± 1.87	5.67 ± 2.01	0.411	0.684
Smoking history (yes/no)	7 (41.18)	24 (36.92)	0.002	0.967
Drinking history (yes/no)	8 (47.06)	28 (43.08)	0.000	0.984
Family history of pancreatic cancer (yes/no)	3 (17.65)	14 (21.54)	0.000	0.987

PNI: Perineural invasion.

Table 2 Comparison of clinical characteristics between the two groups of patients, n (%)

Clinical characteristics	Non-PNI group (n = 17)	PNI group (n = 65)	t	P value
Tumor location
Head	7 (41.18)	48 (73.85)	-	0.033
Body	6 (35.29)	10 (15.38)
Tail	4 (23.53)	7 (10.77)
Tumor size (cm), mean ± SD	4.06 ± 0.89	5.37 ± 1.85	4.158	< 0.001
CA19-9 Level, mean ± SD	260.67 ± 48.92	312.54 ± 57.62	3.745	< 0.001
Overall survival (months), mean ± SD	12.76 ± 3.21	9.85 ± 2.18	3.531	0.002
Abdominal pain	3 (17.65)	32 (49.23)	4.279	0.039

PNI: Perineural invasion; CA19-9: Carbohydrate antigen 19-9.

Table 3 Comparison of pathological features between the two groups of patients, n (%)

Clinical characteristics	Non-PNI group (n = 17)	PNI group (n = 65)	t/χ2	P value
Pathological types			-	0.019
Ductal adenocarcinoma	9 (52.94)	42 (64.62)	-	-
Mucinous adenocarcinoma	5 (29.41)	23 (35.38)
Adenosquamous carcinoma	2 (11.76)	0 (0.00)
Small cell carcinoma	1 (5.88)	0 (0.00)
Differentiation degree			-	< 0.001
Low	2 (11.76)	45 (69.23)	-	-
Medium	3 (17.65)	14 (21.54)
High	12 (70.59)	6 (9.23)
Lymph node infiltration			32.024	< 0.001
Yes	0 (0.00)	51 (78.46)	-	-
No	17 (100.00)	14 (21.54)

PNI: Perineural invasion.

Table 4 Correlation analysis of the occurrence of neural infiltration in pancreatic cancer and clinical pathological features

Items	r	P value
Tumor location	-0.275	0.012
Tumor size (cm)	0.351	0.001
CA19-9 Level	0.376	< 0.001
Overall survival (months)	-0.392	< 0.001
Abdominal pain	0.259	0.019
Differentiation degree	0.656	< 0.001
Lymph node infiltration	-0.275	0.012

CA19-9: Carbohydrate antigen 19-9.