Zeng Y, Zhang JW, Yang J. Endoscopic management of pancreatic cystic neoplasms. World J Gastrointest Oncol 2025; 17(9): 110376 [PMID: 40977669 DOI: 10.4251/wjgo.v17.i9.110376]
Corresponding Author of This Article
Jian Yang, MD, PhD, Associate Chief Physician, Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. yj1984ren@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Sep 15, 2025; 17(9): 110376 Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.110376
Endoscopic management of pancreatic cystic neoplasms
Yan Zeng, Jun-Wen Zhang, Jian Yang
Yan Zeng, Department of Psychology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Jun-Wen Zhang, Jian Yang, Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Author contributions: Zeng Y and Yang J performed the literature search, analyzed the data, and wrote the original manuscript; Zhang JW and Yang J performed the endoscopic procedures, conceptualized and designed the research, and edited the final manuscript; and all authors have read and approved the final manuscript.
Supported by the Education and Teaching Reform Project of the First Clinical College of Chongqing Medical University, No. CMER202305; Natural Science Foundation of Tibet Autonomous Region, No. XZ2024ZR-ZY100(Z); and Program for Youth Innovation in Future Medicine, Chongqing Medical University, No. W0138.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian Yang, MD, PhD, Associate Chief Physician, Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. yj1984ren@qq.com
Received: June 5, 2025 Revised: June 15, 2025 Accepted: August 13, 2025 Published online: September 15, 2025 Processing time: 102 Days and 16.1 Hours
Core Tip
Core Tip: Pancreatic cystic neoplasms (PCNs) represent a broad spectrum of lesions with variable malignant potential, necessitating precise risk stratification and tailored therapeutic strategies. This review synthesizes current advancements in endoscopic management, emphasizing innovations in imaging-guided risk assessment, minimally invasive interventions, and persistent challenges in clinical decision-making. The continuous development in endoscopic techniques, including endoscopic retrograde cholangiopancreatography and endoscopic ultrasound, have enabled minimally invasive alternatives to traditional surgeries for certain PCNs. However, unresolved issues persist, including optimal surveillance intervals for diverse PCN subtypes, standardization of endoscopic ablation protocols, and long-term oncologic outcomes. Additionally, resource availability and operator expertise disparities limit the global adoption of advanced endoscopic modalities. This article underscores the need for multidisciplinary collaboration, artificial intelligence-enhanced surveillance protocols, and cost-effectiveness analyses to optimize patient-centric care. The global community can harmonize management and ensure evidence-based, individualized care for this heterogeneous patient population by integrating evolving technologies with evidence-based guidelines.
