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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2025; 17(9): 105937
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.105937
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.105937
Correlation between KAT6A and PD-L1 expression and role of KAT6A in colorectal cancer
Zhen-Dong Zhou, Jian-Pei Zhao, Shu-Chun Zheng, Department of Anal & Intestinal Surgery, Ningbo No. 2 Hospital, Ningbo 315000, Zhejiang Province, China
Ting-Ting Wang, Department of General Medicine, Ningbo No. 2 Hospital, Ningbo 315000, Zhejiang Province, China
Author contributions: Zhou ZD and Wang TT designed the study; Zhou ZD, Zhao JP, and Zheng SC performed the experiments; Zhou ZD and Wang TT wrote the manuscript.
Institutional review board statement: This study was approved by the ethics committee of Ningbo No. 2 Hospital. Informed consent was obtained from all study participants. All the methods were carried out in accordance with the Declaration of Helsinki.
Institutional animal care and use committee statement: This research did not involve any animal study.
Conflict-of-interest statement: The authors declare no competing financial interests for this article.
Data sharing statement: Not available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ting-Ting Wang, Department of General Medicine, Ningbo No. 2 Hospital, No. 41 Xibei Street, Ningbo 315000, Zhejiang Province, China.
Received: February 11, 2025
Revised: March 31, 2025
Accepted: August 12, 2025
Published online: September 15, 2025
Processing time: 216 Days and 20.5 Hours
Revised: March 31, 2025
Accepted: August 12, 2025
Published online: September 15, 2025
Processing time: 216 Days and 20.5 Hours
Core Tip
Core Tip: KAT6A drives colorectal cancer (CRC) progression and immune evasion by promoting histone H3 propionylation to epigenetically activate PD-L1 expression. Targeting KAT6A or its downstream H3K23pr-PD-L1 axis represents a promising therapeutic strategy to overcome Immune checkpoint inhibitor resistance in CRC.