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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2025; 17(9): 106868
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.106868
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.106868
Status quo of hypercoagulation as a prognostic indicator following neoadjuvant immunochemotherapy in locally advanced gastric cancer
Grigorios Christodoulidis, Department of General Surgery, University Hospital of Larissa, Larissa 41110, Thessalia, Greece
Dimitra Bartzi, Department of Oncology, The 251 Airforce General Hospital, Athens 11525, Greece
Kyriaki Tsagkidou, Department of Gastroenterology, University Hospital of Larisa, Larisa 41100, Thessalia, Greece
Konstantinos Eleftherios Koumarelas, Department of General and Orthopaedic Surgery, Luzerner Kantonsspital Wolhusen, Luzern 6110, Switzerland
Dimitrios Zacharoulis, Department of General Surgery, University of Thessaly, Larisa 41110, Thessalia, Greece
Co-first authors: Grigorios Christodoulidis and Dimitra Bartzi.
Author contributions: Christodoulidis G and Bartzi D contributed equally to this manuscript as co-first authors; Christodoulidis G, Bartzi D, Tsagkidou K, Koumarelas KE, and Zacharoulis D contributed to the discussion and design of the manuscript, and the writing, editing the manuscript, and review of literature; Christodoulidis G designed the overall concept and outline of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Grigorios Christodoulidis, MD, PhD, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Thessalia, Greece.
Received: March 10, 2025
Revised: April 1, 2025
Accepted: July 28, 2025
Published online: September 15, 2025
Processing time: 189 Days and 17.9 Hours
Revised: April 1, 2025
Accepted: July 28, 2025
Published online: September 15, 2025
Processing time: 189 Days and 17.9 Hours
Core Tip
Core Tip: The core message of the review emphasizes that hypercoagulation, observed after neoadjuvant immunochemotherapy in patients with locally advanced gastric cancer, serves as a significant independent prognostic indicator. Elevated coagulation markers such as D-dimer and fibrinogen are associated with poorer overall and disease-free survival rates. The article suggests that monitoring these coagulation parameters can enhance patient management by identifying high-risk individuals and tailoring postoperative care accordingly.