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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2025; 17(9): 103144
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.103144
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.103144
Importance of the pattern of lymph node metastasis in upper and lower gastric cancer
Parbatraj Regmi, Sagar Mani Regmi, Department of Surgery, BP Koirala Institute of Health Sciences, Dharan 56700, Nepal
Anish Paudyal, Department of Surgery, Nepal Medical College, Kathmandu 44600, Nepal
Author contributions: Regmi P wrote the original draft and contributed to conceptualization, writing, reviewing, and editing; Regmi SM and Paudyal A participated in reviewing and editing the manuscript; and all authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Parbatraj Regmi, MD, PhD, Lecturer, Department of Surgery, BP Koirala Institute of Health Sciences, Dharan-18, Dharan 56700, Nepal. regmipar@gmail.com
Received: November 11, 2024
Revised: March 22, 2025
Accepted: April 10, 2025
Published online: September 15, 2025
Processing time: 308 Days and 22.2 Hours
Revised: March 22, 2025
Accepted: April 10, 2025
Published online: September 15, 2025
Processing time: 308 Days and 22.2 Hours
Core Tip
Core Tip: Upper gastric cancer (GC) has a significantly greater degree of malignancy than lower GC. In upper GC, the rate of lymph node (LN) metastasis was greater in groups number 1, 2, 3, and 7 among the different subtypes. In lower GC, the rate of LN metastasis was greater in groups number 3-8. Pathological type, histological grade, tumor stage, tumor-node-metastasis stage, and vascular invasion independently influenced the occurrence of LN metastasis. Age, pathological type, tumor stage, nodes stage, tumor-node-metastasis stage, vascular invasion, and absence of adjuvant chemotherapy independently influenced the prognosis.