Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates Rap1 signaling

Table 1 Clinicopathological features of the 211 patients in the present study

Clinicopathological features		n (%)
Sex	Male	159 (75.4)
	Female	52 (24.6)
Age (years)	< 65	97 (46.0)
	≥ 65	114 (54.0)
Depth of invasion	T1	15 (7.1)
	T2	26 (12.3)
	T3	101 (47.9)
	T4	69 (32.7)
Differentiation	Well	48 (22.7)
	Moderate	69 (32.7)
	Poor	94 (44.5)
Lymph node metastasis	No	66 (31.3)
	Yes	145 (68.7)
TNM stage	I	41 (19.4)
	II	91 (43.1)
	III	49 (23.2)
	IV	30 (14.2)

Table 2 Relationship between uncoupling protein 1 expression and the clinicopathological features of gastric cancer

Characteristics		UCP1 expression		P value	HR (95%CI)
		Negative	Positive
Sex	Male	51	108	0.037a	0.839 (0.702-1.003)
	Female	25	27
Age (years)	≥ 65	42	72	0.787	1.036 (0.802-1.339)
	< 65	34	63
Depth of invasion	T1/T2	10	31	0.084	0.573 (0.298-1.103)
	T3/T4	66	104
Differentiation	Well	9	39	< 0.001b	0.613 (0.451-0.831)
	Moderate	21	48
	Poor	46	48
Lymph mode metastasis	No	18	48	0.074	0.666 (0.419-1.058)
	Yes	58	87
TNM stage	I/II	30	102	< 0.001b	0.522 (0.389-0.701)
	III/IV	46	33

^aP < 0.05.

^bP < 0.01.

χ² test was performed. UCP1: Uncoupling protein 1; OR: Odds ratio; 95%CI: 95% confidence interval.

Table 3 Multivariate logistic regression analysis of the association between uncoupling protein 1 methylation and clinicopathological characteristics in patients with gastric cancer

Clinicopathological characteristics	OR	95%CI	P value
Sex (male vs female)	1.958	0.958-4.001	0.065
Age (≥ 65 years vs < 65 years)	0.870	0.467-1.622	0.662
Depth of invasion (T3/T4 vs T1/T2)	1.677	0.592-4.751	0.330
Differentiation (well & moderate vs poor)	0.446	0.227-0.880	0.020a
Lymph mode metastasis (yes vs no)	1.057	0.455-2.455	0.898
TNM Stage (III and IV vs I/II)	0.233	0.115-0.469	< 0.001b

^aP < 0.05.

^bP < 0.001.

OR: Odds ratio; 95%CI: 95% confidence interval.