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Contents Volume 16 Issue 1 March 20, 2026

Editorial

DNA methylation profiling in central nervous system tumors: Where do we draw the line of clinical utility?

Sumanta Das

World J Exp Med 16(1):115070. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.115070

Abstract (94) | Core Tip (89) | Full Article (HTML) (297) | Full Article (PDF)-442K (32) | Full Article with Cover (PDF)-653K (156) | Full Article (XML)-156K (14) | Audio-398K (2) | Peer-Review Report-340K (15) | Answering Reviewers-351K (16) | Received: 10/06/2025 | Revised: 11/09/2025 | Accepted: 02/03/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (942) | Similar Articles (1) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Review

Renin-angiotensin system blockade attenuates brain mitochondrial dysfunction, oxidative stress, and neuroinflammation associated with hypertension, metabolic disorders, and aging

Sebastián García Menéndez, Felipe Inserra, Elena MV de Cavanagh, Leon Ferder, Walter Manucha

World J Exp Med 16(1):113259. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.113259

Abstract (96) | Core Tip (95) | Full Article (HTML) (453) | Figures (1-2) (72) | Tables (1-1) (72) | Full Article (PDF)-2852K (47) | Full Article with Cover (PDF)-3035K (19) | Full Article (XML)-227K (18) | Audio-2004K (2) | Peer-Review Report-231K (19) | Answering Reviewers-60K (25) | Received: 08/20/2025 | Revised: 10/25/2025 | Accepted: 01/20/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1261) | Similar Articles (216) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Deciphering the interplay between hypoxia, angiogenesis, and endoplasmic reticulum stress in carcinogenesis: A narrative review

Shikha Bhardwaj, Shweta Pandey, Debasish Kumar Ghosh, Tapan Sharma, Buddhi Prakash Jain

World J Exp Med 16(1):115478. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.115478

Abstract (92) | Core Tip (85) | Full Article (HTML) (206) | Figures (1-2) (64) | Tables (1-1) (72) | Full Article (PDF)-1176K (31) | Full Article with Cover (PDF)-1386K (16) | Full Article (XML)-308K (17) | Audio-107K (1) | Peer-Review Report-237K (16) | Answering Reviewers-57K (16) | Received: 10/17/2025 | Revised: 11/25/2025 | Accepted: 01/22/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (924) | Similar Articles (131) | Timeline of Article Publication (0) | Authors Evaluation (2) | Article Quality Tracking (0) | Cite |

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Very low-density lipoprotein and the human health

Alok Bharadwaj, Manas Taneja, Sneha Dubey, Aditya Saxena

World J Exp Med 16(1):117024. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.117024

Abstract (86) | Core Tip (84) | Full Article (HTML) (286) | Figures (1-4) (64) | Tables (1-5) (64) | Full Article (PDF)-1273K (76) | Full Article with Cover (PDF)-1480K (23) | Full Article (XML)-332K (14) | Audio-672K (2) | Peer-Review Report-225K (16) | Answering Reviewers-100K (11) | Received: 11/26/2025 | Revised: 12/23/2025 | Accepted: 02/12/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (933) | Similar Articles (29) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Reader Comments (1) | Cite |

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Melanoma leptomeningeal disease: Advances in diagnosis and emerging therapeutic strategies

Michael L Middleton, Brandon Lucke-Wold

World J Exp Med 16(1):117938. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.117938

Abstract (96) | Core Tip (86) | Full Article (HTML) (286) | Figures (1-1) (86) | Tables (1-1) (67) | Full Article (PDF)-1668K (27) | Full Article with Cover (PDF)-1875K (12) | Full Article (XML)-298K (17) | Audio-369K (1) | Peer-Review Report-302K (11) | Answering Reviewers-101K (15) | Received: 12/18/2025 | Revised: 01/12/2026 | Accepted: 02/03/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1161) | Similar Articles (0) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Minireviews

Cardiac amyloidosis: From diagnosis to therapeutics breakthroughs

Maha Bouziane, Omar Moufid, Rachida Habbal

World J Exp Med 16(1):112270. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.112270

Abstract (81) | Core Tip (89) | Full Article (HTML) (395) | Figures (1-4) (64) | Tables (1-2) (63) | Full Article (PDF)-5253K (46) | Full Article with Cover (PDF)-5463K (17) | Full Article (XML)-261K (18) | Audio-369K (1) | Peer-Review Report-213K (18) | Answering Reviewers-164K (17) | Supplementary Material-667K (22) | Received: 07/22/2025 | Revised: 08/13/2025 | Accepted: 02/02/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1312) | Similar Articles (283) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Evidence-based review and clinical practice recommendations for the diagnosis and management of common oral mucosal lesions

Giath Gazal, Anas B Alsalhani, Bassel Tarakji, Mohammad Zakaria Nassani

World J Exp Med 16(1):115535. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.115535

Abstract (96) | Core Tip (89) | Full Article (HTML) (482) | Tables (1-5) (83) | Full Article (PDF)-444K (46) | Full Article with Cover (PDF)-652K (18) | Full Article (XML)-112K (16) | Audio-248K (3) | Peer-Review Report-244K (12) | Answering Reviewers-179K (15) | Received: 10/18/2025 | Revised: 11/19/2025 | Accepted: 01/20/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1073) | Similar Articles (422) | Timeline of Article Publication (1) | Authors Evaluation (3) | Article Quality Tracking (0) | Cite |

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Double-edged role of N6-methyladenosine reader YTH structural domain family protein 2 in neurological disorders: Molecular mechanisms and translational prospects

Yu-Meng Liu, Ming Liu, Hang Yuan, Bin Li

World J Exp Med 16(1):116383. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.116383

Abstract (80) | Core Tip (73) | Full Article (HTML) (217) | Figures (1-1) (64) | Full Article (PDF)-1306K (19) | Full Article with Cover (PDF)-1515K (15) | Full Article (XML)-73K (16) | Audio-347K (1) | Peer-Review Report-193K (14) | Answering Reviewers-169K (19) | Received: 11/10/2025 | Revised: 12/23/2025 | Accepted: 02/11/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (738) | Similar Articles (7) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Unconventional mechanisms of resveratrol in atherosclerosis prevention and management

Nadim Chaarani, Riyad Mroweh, Razan Moghnieh, Mohammad Kheir Chahine, Hassan Zaiter, Saleh-Yezan Abdulaal, Nazih Obeid, Mohamad Tlais, Joy Raheb, Hadi Farhat, Razan Abdulaal

World J Exp Med 16(1):116771. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.116771

Abstract (92) | Core Tip (76) | Full Article (HTML) (315) | Figures (1-1) (60) | Full Article (PDF)-708K (30) | Full Article with Cover (PDF)-919K (16) | Full Article (XML)-105K (15) | Audio-677K (1) | Peer-Review Report-224K (12) | Answering Reviewers-167K (17) | Received: 11/19/2025 | Revised: 12/03/2025 | Accepted: 01/19/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (785) | Similar Articles (57) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Myocardiocyte senescence in ischemic heart disease and breathome changes

Basheer Abdullah Marzoog, Philipp Kopylov

World J Exp Med 16(1):117186. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.117186

Abstract (80) | Core Tip (73) | Full Article (HTML) (167) | Figures (1-1) (66) | Tables (1-1) (67) | Full Article (PDF)-641K (22) | Full Article with Cover (PDF)-851K (16) | Full Article (XML)-170K (20) | Audio-1285K (1) | Peer-Review Report-456K (12) | Answering Reviewers-91K (14) | Received: 11/30/2025 | Revised: 01/13/2026 | Accepted: 02/27/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (710) | Similar Articles (9) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Neurobiological mechanisms linking vitamin d signaling to cognitive decline and neurodegeneration: Untangling epidemiology, pathophysiology, and evidence

Neha Choudhary, Maheen Zahid, Muhammad Ahmad, Muneeba Shaukat, Muhammad Tariq, Soura Rajeshwara, Shermeen Usman, Taimoor Wajid, Ayoola Awosika

World J Exp Med 16(1):118761. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.118761

Abstract (92) | Core Tip (76) | Full Article (HTML) (281) | Figures (1-4) (77) | Tables (1-1) (65) | Full Article (PDF)-3466K (36) | Full Article with Cover (PDF)-3676K (17) | Full Article (XML)-145K (16) | Audio-3509K (2) | Peer-Review Report-243K (16) | Answering Reviewers-206K (11) | Received: 01/09/2026 | Revised: 01/24/2026 | Accepted: 02/11/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (892) | Similar Articles (89) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Case Control Study

Diagnostic utility of circulating interleukin-1 beta and microRNA-146a in differentiating febrile seizures from other pediatric conditions

Saeed Mohammadi, Mwssa Abbood Hameed Ati, Fakhri Sadat Seyedhosseini, Mojtaba Zare Ebrahimabad, Mohsen Saeidi, Seyed Ahmad Hosseini, Mahmoud Darweesh, Ahmed Al-Harrasi, Yaghoub Yazdani

World J Exp Med 16(1):112061. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.112061

Abstract (101) | Core Tip (88) | Full Article (HTML) (159) | Figures (1-2) (61) | Tables (1-1) (67) | Full Article (PDF)-1084K (26) | Full Article with Cover (PDF)-1293K (11) | Full Article (XML)-91K (19) | Audio-792K (1) | Peer-Review Report-260K (15) | Answering Reviewers-187K (13) | Received: 07/16/2025 | Revised: 08/06/2025 | Accepted: 01/05/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1162) | Similar Articles (0) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Retrospective Cohort Study

Differences of immunohistochemical profiling of MOC-31, caveolin-1, connexin-43, Ki-67 in ameloblastic fibroma, ameloblastic fibrodentinoma, ameloblastic fibro-odontoma, and odontomas

Natalia González Umpiérrez, Estefania Sicco, Felipe Silveira, Aurita Veronica Beovide, Ronell Bologna-Molina

World J Exp Med 16(1):115508. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.115508

Abstract (83) | Core Tip (87) | Full Article (HTML) (162) | Figures (1-4) (58) | Tables (1-3) (65) | Full Article (PDF)-47321K (27) | Full Article with Cover (PDF)-47509K (15) | Full Article (XML)-90K (14) | Audio-1793K (1) | Peer-Review Report-257K (15) | Answering Reviewers-260K (18) | Received: 10/17/2025 | Revised: 11/03/2025 | Accepted: 12/30/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1133) | Similar Articles (22) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Diabetic ketoacidosis in patients with type 2 diabetes: Risk factors for mortality and adverse outcomes

Vishnu Chandrabalan, Timothy Howcroft, Mohammed Khalid Alkhalifah, Noorulanne Younis, Ebrahim Aldhafiri, Joseph M Pappachan

World J Exp Med 16(1):117464. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.117464

Abstract (89) | Core Tip (76) | Full Article (HTML) (291) | Figures (1-1) (61) | Tables (1-6) (63) | Full Article (PDF)-579K (45) | Full Article with Cover (PDF)-790K (21) | Full Article (XML)-91K (22) | Audio-448K (2) | Peer-Review Report-197K (17) | Answering Reviewers-129K (12) | Received: 12/23/2025 | Revised: 01/11/2026 | Accepted: 02/05/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1048) | Similar Articles (22) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Clinical Trials Study

Effects of olopatadine hydrochloride on substance P concentrations in nasal secretions and nasal symptoms

Fumihiko Katagiri, Saori Hatoyama-Tanaka, Tetsuo Watanabe, Risa Takayanagi, Masashi Suzuki, Yasuhiko Yamada

World J Exp Med 16(1):116584. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.116584

Abstract (81) | Core Tip (76) | Full Article (HTML) (177) | Figures (1-3) (65) | Tables (1-3) (62) | Full Article (PDF)-865K (25) | Full Article with Cover (PDF)-1077K (14) | Full Article (XML)-55K (14) | Audio-2454K (4) | Peer-Review Report-190K (18) | Answering Reviewers-267K (11) | Received: 11/14/2025 | Revised: 01/20/2026 | Accepted: 02/24/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (876) | Similar Articles (15) | Timeline of Article Publication (1) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Observational Study

Acute childhood leukemia and ophthalmic manifestations: An observational study from Eastern India

Sucheta Parija, Shanmugasundaram Palanisamy

World J Exp Med 16(1):111034. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.111034

Abstract (93) | Core Tip (83) | Full Article (HTML) (180) | Figures (1-4) (59) | Tables (1-2) (69) | Full Article (PDF)-5328K (24) | Full Article with Cover (PDF)-5538K (24) | Full Article (XML)-81K (24) | Audio-2304K (1) | Peer-Review Report-191K (16) | Answering Reviewers-122K (15) | Received: 06/21/2025 | Revised: 08/14/2025 | Accepted: 01/06/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (968) | Similar Articles (169) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Correlation between heart rate variability and severity of coronary atherosclerosis: Looking for non-invasive indicators of the disease severity

Michal Kuzemczak, Izabela Miechowicz, Rafal Januszek, Tomasz Siminiak

World J Exp Med 16(1):111197. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.111197

Abstract (96) | Core Tip (89) | Full Article (HTML) (157) | Figures (1-3) (63) | Tables (1-4) (67) | Full Article (PDF)-2876K (33) | Full Article with Cover (PDF)-3086K (14) | Full Article (XML)-84K (18) | Audio-332K (1) | Peer-Review Report-213K (16) | Answering Reviewers-77K (19) | Received: 06/24/2025 | Revised: 08/04/2025 | Accepted: 01/05/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (850) | Similar Articles (12) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Randomized Clinical Trial

Indocyanine green doped with chitosan nanoparticles based antimicrobial photodynamic therapy in periodontitis patients: A randomized clinical trial

Subash Chandra Raj, Sudip Sen, Debajani Baral, Devapratim Mohanty, Shaheda Tabassum, Swoyangprava Sil, Mrutyunjaya Sahu

World J Exp Med 16(1):117125. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.117125

Abstract (95) | Core Tip (83) | Full Article (HTML) (247) | Figures (1-8) (62) | Tables (1-18) (66) | Full Article (PDF)-11268K (37) | Full Article with Cover (PDF)-11476K (19) | Full Article (XML)-195K (16) | Audio-368K (1) | Peer-Review Report-221K (20) | Answering Reviewers-57K (16) | Received: 11/28/2025 | Revised: 12/22/2025 | Accepted: 02/03/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1053) | Similar Articles (87) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Basic Study

Abnormalities of liver sinusoidal endothelial cells in primary biliary cholangitis

Evangelos Thalassinos, George Notas, Costantinos Xidakis, Ioannis Drygiannakis, Ourania Sfakianaki, Ioannis Tsomidis, Elias Kouroumalis

World J Exp Med 16(1):114313. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.114313

Abstract (95) | Core Tip (84) | Full Article (HTML) (173) | Figures (1-2) (65) | Tables (1-2) (65) | Full Article (PDF)-947K (29) | Full Article with Cover (PDF)-1157K (19) | Full Article (XML)-153K (16) | Audio-974K (2) | Peer-Review Report-239K (15) | Answering Reviewers-71K (17) | Received: 09/17/2025 | Revised: 10/19/2025 | Accepted: 01/05/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (861) | Similar Articles (43) | Timeline of Article Publication (1) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Experimental beneficial effect of rosuvastatin on burn wound healing in a rat model

Alexandra G Marneri, Efstathios T Pavlidis, Kalliopi E Stavrati, Athanasios Kofinas, Christina Mouratidou, Ioannis Gkoutziotis, Serafeim-Chrysovalantis Kotoulas, Christina Marouda, Dimitra Psalla, Konstantinos D Ballas, Theodoros E Pavlidis

World J Exp Med 16(1):115208. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.115208

Abstract (105) | Core Tip (85) | Full Article (HTML) (213) | Figures (1-3) (66) | Tables (1-7) (71) | Full Article (PDF)-21618K (30) | Full Article with Cover (PDF)-21827K (12) | Full Article (XML)-177K (19) | Audio-445K (1) | Peer-Review Report-194K (13) | Answering Reviewers-71K (14) | Received: 10/10/2025 | Revised: 11/04/2025 | Accepted: 01/05/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1148) | Similar Articles (8) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Antidiabetic effects of Gymnema sylvestre and metformin co-therapy in a type 2 diabetic rat model

Ajay Kodiyatar, Akhilesh Mishra, Megh Singh Dhakad, Vandana Roy, Mirza Masroor Ali Beg, Niket Rai

World J Exp Med 16(1):116252. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.116252

Abstract (106) | Core Tip (86) | Full Article (HTML) (301) | Figures (1-5) (67) | Tables (1-2) (66) | Full Article (PDF)-925K (46) | Full Article with Cover (PDF)-1131K (21) | Full Article (XML)-68K (17) | Audio-605K (1) | Peer-Review Report-210K (17) | Answering Reviewers-76K (15) | Received: 11/07/2025 | Revised: 01/06/2026 | Accepted: 02/14/2026 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1241) | Similar Articles (40) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Letter to the Editor

Leukoplakia of oral cavity and urinary bladder are premalignant to squamous carcinoma

Mohamed Wishahi

World J Exp Med 16(1):114526. Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.114526

Abstract (89) | Core Tip (83) | Full Article (HTML) (247) | Full Article (PDF)-412K (22) | Full Article with Cover (PDF)-624K (15) | Full Article (XML)-72K (14) | Audio-916K (1) | Peer-Review Report-289K (15) | Answering Reviewers-336K (13) | Received: 09/21/2025 | Revised: 11/06/2025 | Accepted: 12/29/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (737) | Similar Articles (0) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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