Antidiabetic effects of Gymnema sylvestre and metformin co-therapy in a type 2 diabetic rat model

doi:10.5493/wjem.v16.i1.116252

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Exp Med. Mar 20, 2026; 16(1): 116252
Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.116252

Table 1 Induction of diabetes (pre-treatment data), mean ± SD

Group	Weight (g; baseline)	Weight (g; day 0)	FBG (mg/dL; day 0)
NC	163.16 ± 9.95	265.83 ± 21.77	101.16 ± 12.78
DC	163.16 ± 6.64	302.83 ± 56.02	476.00 ± 80.88^a
Met	158.16 ± 5.38	235.50 ± 22.98	461.50 ± 13.50^a
GS	154.66 ± 4.84	269.50 ± 32.77	448.66 ± 10.26^a
Met + GS	156.00 ± 6.54	280.16 ± 24.01	436.33 ± 27.78^a

^aP < 0.05 vs normal control.

NC: Normal control; DC: Diabetic control; Met: Metformin; GS: Gymnema sylvestre; FBG: Fasting blood glucose.

Full Size Table

Table 2 Effects of treatments on day 28, mean ± SD

Group	Weight (gm)	FBG (mg/dL)		Cholesterol (g/L)		Creatinine (mg/dL)		Hb1Ac (g/L)
Group	Day 28	Day 7	Day 28	Day 0	Day 28	Day 0	Day 28	Day 0	Day 28
DC	293.0 ± 33.41	445.66 ± 51.74	401.33 ± 24.548	351.6 ± 75.99	345.14 ± 70.77	2.05 ± 0.47	1.85 ± 0.04	10.55 ± 0.57	9.95 ± 0.49
Met	389.8 ± 19.53^a	409.66 ± 19.53^a	122.50 ± 6.15^a	331.6 ± 10.06	106.49 ± 2.73^a	1.85 ± 0.76	0.44 ± 0.03^a	10.65 ± 0.11	5.82 ± 0.15^a
GS	393.0 ± 30.21^a	423.83 ± 13.61	296.33 ± 8.26^a^,^b	323.9 ± 16.91	293.43 ± 3.29^a^,^b	1.77 ± 0.89	0.69 ± 0.04^a^,^b	10.62 ± 0.27	8.24 ± 0.13^a^,^b
Met + GS	421.8 ± 27.96^a^,^b	395.83 ± 10.88^a^,^b	176.50 ± 9.20^a^,^b	315.7 ± 14.53	208.99 ± 1.18^b	1.74 ± 0.12	0.54 ± 0.02^a^,^b	10.65 ± 0.70	7.26 ± 0.09^a^,^b

^aP < 0.05 vs normal control.

^bP < 0.05 vs metformin.

DC: Diabetic control; Met: Metformin; GS: Gymnema sylvestre; FBG: Fasting blood glucose; Hb1Ac: Glycated hemoglobin.

Full Size Table

Citation: Kodiyatar A, Mishra A, Dhakad MS, Roy V, Beg MMA, Rai N. Antidiabetic effects of Gymnema sylvestre and metformin co-therapy in a type 2 diabetic rat model. World J Exp Med 2026; 16(1): 116252
URL: https://www.wjgnet.com/2220-315x/full/v16/i1/116252.htm
DOI: https://dx.doi.org/10.5493/wjem.v16.i1.116252