Kuzemczak M, Miechowicz I, Januszek R, Siminiak T. Correlation between heart rate variability and severity of coronary atherosclerosis: Looking for non-invasive indicators of the disease severity. World J Exp Med 2026; 16(1): 111197 [DOI: 10.5493/wjem.v16.i1.111197]
Corresponding Author of This Article
Michal Kuzemczak, MD, PhD, Assistant Professor, Division of Emergency Medicine, Poznan University of Medical Sciences, Rokietnicka 7 Street, Poznan 60-806, Poland. michal.kuzemczak@gmail.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Observational Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mar 20, 2026 (publication date) through Mar 20, 2026
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Journal Information of This Article
Publication Name
World Journal of Experimental Medicine
ISSN
2220-315x
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Kuzemczak M, Miechowicz I, Januszek R, Siminiak T. Correlation between heart rate variability and severity of coronary atherosclerosis: Looking for non-invasive indicators of the disease severity. World J Exp Med 2026; 16(1): 111197 [DOI: 10.5493/wjem.v16.i1.111197]
World J Exp Med. Mar 20, 2026; 16(1): 111197 Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.111197
Correlation between heart rate variability and severity of coronary atherosclerosis: Looking for non-invasive indicators of the disease severity
Michal Kuzemczak, Izabela Miechowicz, Rafal Januszek, Tomasz Siminiak
Michal Kuzemczak, Division of Emergency Medicine, Poznan University of Medical Sciences, Poznan 60-806, Poland
Michal Kuzemczak, Department of Interventional Cardiology and Internal Diseases, Military Institute of Medicine – National Research Institute, Legionowo 05-119, Poland
Michal Kuzemczak, Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw 04-749, Poland
Izabela Miechowicz, Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan 60-806, Poland
Rafal Januszek, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Cracow University, Cracow 30-705, Poland
Tomasz Siminiak, Department of Interventional Cardiology, HCP Medical Centre, Poznan University of Medical Sciences, Poznan 61-485, Poland
Author contributions: Kuzemczak M designed and conducted the study and wrote the manuscript; Miechowicz I, Kramer L, and Moczko J contributed to the analysis; Januszek R provided clinical advice; Siminiak T supervised the study.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Poznan University of Medical Sciences (Poznań, Poland).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at michal.kuzemczak@gmail.com. A consent for data sharing was not obtained from the included patients since the presented data are anonymized and there is no risk of identification.
Corresponding author: Michal Kuzemczak, MD, PhD, Assistant Professor, Division of Emergency Medicine, Poznan University of Medical Sciences, Rokietnicka 7 Street, Poznan 60-806, Poland. michal.kuzemczak@gmail.com
Received: June 25, 2025 Revised: August 4, 2025 Accepted: January 5, 2026 Published online: March 20, 2026 Processing time: 263 Days and 14.9 Hours
Core Tip
Core Tip: This study explores the relationship between heart rate variability (HRV) and angiographic severity of ischemic heart disease as reflected by the Gensini score. While traditional HRV indices (standard deviation of NN intervals, root mean square of successive differences, spectral indices) showed no significant correlations, several novel parameters - including de Hann sinus tachycardia index, van Geijn interbeat interval difference, Huey long-term variability, and Dalton mean absolute beat-to-beat - demonstrated weak but statistically significant associations. These findings highlight the potential value of emerging HRV indices in assessing coronary atherosclerosis severity and suggest new directions for research in noninvasive cardiac risk stratification in stable ischemic heart disease patients.
