Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Exp Med. Mar 20, 2026; 16(1): 115208
Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.115208
Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.115208
Experimental beneficial effect of rosuvastatin on burn wound healing in a rat model
Alexandra G Marneri, Christina Mouratidou, Serafeim-Chrysovalantis Kotoulas, Intensive Care Unit, Hippokration General Hospital, Thessaloniki 54642, Greece
Efstathios T Pavlidis, Kalliopi E Stavrati, Theodoros E Pavlidis, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece
Athanasios Kofinas, Department of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, Hippokration General Hospital, Aristotle University of Thessaloniki, School of Medicine, Thessaloniki 54642, Greece
Ioannis Gkoutziotis, Konstantinos D Ballas, The Fifth Department of Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece
Christina Marouda, Dimitra Psalla, Laboratory of Pathology, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Co-corresponding authors: Efstathios T Pavlidis and Theodoros E Pavlidis.
Author contributions: Marneri AG, Pavlidis ET, and Stavrati KE designed research and analysed data; Kofinas A, Mouratidou C, Gkoutziotis I, and Kotoulas SC performed research, contributed new analytic tools, evaluated data and review the paper; Marouda C and Psalla D performed histopathology research, analyzed and interpreted data; Βallas KD and Pavlidis TE analysed data review and approved the paper; Pavlidis ET and Pavlidis TE contributed equally to this manuscript as co-corresponding authors. All authors have read and approved the final manuscript.
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the care and use of laboratory animals. The experimental protocol was approved by the Department of Animal Health, Directorate of Veterinary Policy, Prefecture of Thessaloniki, Greece [approval No. 608344(2695)]; protocol number EL-54-BIOexp-10, Laboratory of Development-Breeding of Animal Models and Biomedical Research, School of Veterinary Medicine, Aristotle University of Thessaloniki, Greece.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Corresponding author: Theodoros E Pavlidis, MD, PhD, Professor Emeritus, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece.
Received: October 14, 2025
Revised: November 4, 2025
Accepted: January 5, 2026
Published online: March 20, 2026
Processing time: 155 Days and 15.7 Hours
Revised: November 4, 2025
Accepted: January 5, 2026
Published online: March 20, 2026
Processing time: 155 Days and 15.7 Hours
Core Tip
Core Tip: Overall, the data from this original preclinical study confirm that rosuvastatin does not act unidimensionally but simultaneously influences the inflammatory, angiogenic, and reparative phases of burn wound healing. These findings are consistent with data from other statins and expand our understanding of the mechanisms of action of rosuvastatin, hi