Effects of olopatadine hydrochloride on substance P concentrations in nasal secretions and nasal symptoms

Table 1 Classification of the severity of allergic rhinitis symptoms

Severity		Paroxysmal sneezing or rhinorrhea1
		4 (++++)	3 (+++)	2 (++)	1 (+)	0 (-)
Nasal blockage	4 (++++)	Most severe	Most severe	Most severe	Most severe	Most severe
	3 (+++)	Most severe	Severe	Severe	Severe	Severe
	2 (++)	Most severe	Severe	Moderate	Moderate	Moderate
	1 (+)	Most severe	Severe	Moderate	Mild	Mild
	0 (-)	Most severe	Severe	Moderate	Mild	No symptoms

¹Select more severe one, sneezing or rhinorrhea.

Table 2 Classification of the severity of allergic rhinitis symptoms: Severity of the symptoms

Severity	Types
	Sneezing1	Rhinorrhea2	Nasal blockage
4 (++++)	≥ 21 times	≥ 21 times	Nose completely obstructed all day
3 (+++)	11-20 times	11-20 times	Severe nasal blockage causing oral breathing during a day
2 (++)	6-10 times	60-10 times	Severe nasal blockage causing occasional oral breathing during a day
1 (+)	1-5 times	1-5 times	Nasal blockage without oral breathing
0 (-)	Below +	Below +	Below +

¹Average number of episodes of paroxysmal sneezing in a day.

²Average number of episodes of nose blowing per day.

Table 3 Number of patients of difference between substance P concentration in nasal secretions and scores for each nasal symptom after administration of olopatadine

	Substance P concentration, nasal symptoms
	(+, +)	(+, -)	(-, +)	(-, -)
Sneezing	0	2	2	8
Rhinorrhea	0	2	2	8
Nasal blockage	0	2	1	9
Severity	0	2	2	8