Bhardwaj S, Pandey S, Ghosh DK, Sharma T, Jain BP. Deciphering the interplay between hypoxia, angiogenesis, and endoplasmic reticulum stress in carcinogenesis: A narrative review. World J Exp Med 2026; 16(1): 115478 [DOI: 10.5493/wjem.v16.i1.115478]
Corresponding Author of This Article
Buddhi Prakash Jain, Assistant Professor, Department of Zoology, Gene Expression and Signaling Lab., Mahatma Gandhi Central University, MGCUB, Motihari 845401, Bihar, India. buddhiprakash@mgcub.ac.in
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Review
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mar 20, 2026 (publication date) through Mar 20, 2026
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Journal Information of This Article
Publication Name
World Journal of Experimental Medicine
ISSN
2220-315x
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Bhardwaj S, Pandey S, Ghosh DK, Sharma T, Jain BP. Deciphering the interplay between hypoxia, angiogenesis, and endoplasmic reticulum stress in carcinogenesis: A narrative review. World J Exp Med 2026; 16(1): 115478 [DOI: 10.5493/wjem.v16.i1.115478]
Shikha Bhardwaj, Buddhi Prakash Jain, Department of Zoology, Gene Expression and Signaling Lab., Mahatma Gandhi Central University, Motihari 845401, Bihar, India
Shweta Pandey, Biotechnology, Govt Vishwanath Yadav Tamaskar Post-Graduate Autonomous College Durg, Chhattisgarh 491001, India
Debasish Kumar Ghosh, Research and Development Division, Accelgen Bharat Bioinnovations, Kolkata 700051, West Bengal, India
Tapan Sharma, Department of Genetic and Cellular Medicine, UMass Chan Medical School, Worcester, MA 01655, United States
Co-corresponding authors: Shweta Pandey and Buddhi Prakash Jain.
Author contributions: Bhardwaj S wrote the original and revised draft; Jain BP wrote, supervised, conceived, verified, reviewed, and edited the manuscript; Pandey S supervised, reviewed and edited the final draft; Ghosh DK helped in reviewing, Sharma T helped in the reviewing and editing for grammatical correctness. All authors were involved in the critical review and have read and approved the final manuscript. Regarding two co-corresponding author, Jain BP is the main corresponding author. Pandey S is working in the field of Cancer Biology and Angiogenesis. She significantly contributed for making the manuscript more significant and useful. She added many parts in the manuscript. Also, she helped in the revising and editing the manuscript throughout the development. She was given credit as a co-corresponding author.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Buddhi Prakash Jain, Assistant Professor, Department of Zoology, Gene Expression and Signaling Lab., Mahatma Gandhi Central University, MGCUB, Motihari 845401, Bihar, India. buddhiprakash@mgcub.ac.in
Received: October 20, 2025 Revised: November 25, 2025 Accepted: January 22, 2026 Published online: March 20, 2026 Processing time: 148 Days and 20.7 Hours
Core Tip
Core Tip: This review explores the interplay between hypoxia, endoplasmic reticulum stress and angiogenesis, highlighting the central regulatory role of hypoxia-inducible factors (HIFs). It highlights how HIF signaling links oxygen deprivation with vascular adaptation and protein-folding stress responses. Understanding this integrated network provides valuable insight into how tumors exploit these pathways for survival and offers potential molecular targets for therapeutic intervention. In future, this will lead to a better understanding of their synergistic relationship and how modulation of either pathway can potentially result in restraining the aggravated vasculogenesis which promotes the aberrant cell proliferation in cancer and in some case, make them more resistant to chemo and radiotherapy.
