Cardiac amyloidosis: From diagnosis to therapeutics breakthroughs

Table 1 Multiparametric echocardiographic score for the diagnosis of Cardiac amyloidosis

Echocardiographic parameter	Diagnostic threshold	Score
Relative LV wall thickness (IVS + PWT)/LVEDD	> 0.6	3 points
E/e’ ratio (Doppler E wave to e’ velocity)	> 11	1 point
Tricuspid annular plane systolic excursion	≤ 19 mm	2 points
LV global longitudinal strain absolute value	≤ -13%	1 point
Systolic longitudinal strain apex-to-base ratio	> 2.9	3 points

IVS: Interventricular septal wall thickness; PWT: Posterior wall thickness; LVEDD: Left ventricular end-diastolic diameter; LV: Left ventricular.

Table 2 Perugini scoring system for cardiac amyloid imaging interpretation

Perugini score	Cardiac uptake	Bone uptake	Interpretation
0	Absent	Normal	No evidence of cardiac amyloid deposition
1	Mild, less than bone uptake	Normal	Low-grade uptake, non-specific
2	Moderate	Reduced	Suggestive of transthyretin cardiac amyloidosis
3	Strong	Mild or absent	Highly suggestive of transthyretin cardiac amyloidosis