Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Exp Med. Mar 20, 2026; 16(1): 112270
Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.112270
Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.112270
Cardiac amyloidosis: From diagnosis to therapeutics breakthroughs
Maha Bouziane, Omar Moufid, Rachida Habbal, Department of Cardiology, Ibn Rochd University Hospital of Casablanca, Casablanca 20000, Casablanca-Settat, Morocco
Author contributions: Bouziane M conceptualized the research topic, conducted the literature review, wrote the manuscript, and approved the final version; Moufid O contributed to the writing, critically revised the manuscript, and approved the final version; Habbal R assisted in the literature review and contributed to the final manuscript revision.
Conflict-of-interest statement: No conflicts of interest to disclose.
Corresponding author: Maha Bouziane, Assistant Professor, Department of Cardiology, Ibn Rochd University Hospital of Casablanca, 1 rue des hopitaux, Casablanca 20000, Casablanca-Settat, Morocco. mahabouziane@gmail.com
Received: July 23, 2025
Revised: August 13, 2025
Accepted: February 2, 2026
Published online: March 20, 2026
Processing time: 235 Days and 10 Hours
Revised: August 13, 2025
Accepted: February 2, 2026
Published online: March 20, 2026
Processing time: 235 Days and 10 Hours
Core Tip
Core Tip: This review highlights recent advances in cardiac amyloidosis (CA), a progressive infiltrative cardiomyopathy caused by amyloid fibril deposition in cardiac tissues. Improved recognition through advanced non-invasive imaging techniques and significant progress in disease-modifying therapies have transformed diagnosis and treatment. A multimodal diagnostic strategy and early identification are critical to improving patient outcomes. The review emphasizes the need for standardized diagnostic algorithms, increased clinical awareness, and a multidisciplinary approach to optimize care for patients with CA.