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World J Exp Med. Mar 20, 2026; 16(1): 113259
Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.113259
Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.113259
Renin-angiotensin system blockade attenuates brain mitochondrial dysfunction, oxidative stress, and neuroinflammation associated with hypertension, metabolic disorders, and aging
Sebastián García Menéndez, Department of Pathology, Facultad de Ciencias Médicas, Univer
Felipe Inserra, Department of Postgraduate, Austral University, Pilar 1630, Argentina
Elena MV de Cavanagh, Department of Postgraduate, Austral University Hospital, Arterial Hypertens Ctr, Sch Biomed Sci, CABA 1629, Argentina
Leon Ferder, Department of Pharmacology, Universidad Maimónides, Ciudad Autónoma de Buenos Aires C1405, Argentina
Walter Manucha, Department of Pathology, Institute of Medicine and Experimental Biology of Cuyo, National Council for Scientific and Technological Research, National University of Cuyo, Laboratory of Basic and Translational Experimental Pharmacology, Faculty of Medical Sciences, Mendoza 5500, Argentina
Author contributions: García Menéndez S, Inserra F, de Cavanagh EMV, Ferder L and Manucha W were responsible for writing, discussion and preparation of this manuscript, and have also read and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Walter Manucha, PhD, Professor, Department of Pathology, Institute of Medicine and Experimental Biology of Cuyo, National Council for Scientific and Techno
Received: August 20, 2025
Revised: October 25, 2025
Accepted: January 20, 2026
Published online: March 20, 2026
Processing time: 207 Days and 13.6 Hours
Revised: October 25, 2025
Accepted: January 20, 2026
Published online: March 20, 2026
Processing time: 207 Days and 13.6 Hours
Core Tip
Core Tip: This study highlights renin-angiotensin system blockade as a promising strategy for preventing brain damage associated with hypertension, metabolic disorders, and aging. These conditions accelerate mitochondrial dysfunction, oxidative stress, and neuroinflammation. Our work focuses on the strategic use of angiotensin receptor blockers and ACE2 activators, demonstrating their potential to mitigate these pathological processes and offering a novel avenue for the prevention and treatment of vascular dementia and other neurodegenerative diseases.