Differences of immunohistochemical profiling of MOC-31, caveolin-1, connexin-43, Ki-67 in ameloblastic fibroma, ameloblastic fibrodentinoma, ameloblastic fibro-odontoma, and odontomas

Table 1 Global and individual immunoexpression results

Sample (n)	Cav-1	MOC-31	Cx-43	Ki-67
AFO/AFD[6]	6 (100.0)	3 (50.0)	6 (100.0)	3 (50.0)
AF[8]	6 (75.0)	5 (62.5)	5 (62.5)	4 (50.0)
O[6]	5 (83.3)	0 (0.0)	0 (0.0)	0 (0.0)
PC[5]	1 (20.0)	1 (20.0)	3 (60.0)	1 (20.0)
OT[20]	17 (85.0)	8 (40.0)	11 (55.0)	7 (35.0)
Global[25]	18 (72.0)	9 (36.0)	14 (56.0)	8 (32.0)

Data are expressed as n (%). Overall and individual percentage of expression for caveolin-1, MOC-31, connexin-43, and Ki-67 in ameloblastic fibromas, ameloblastic/fibro-odontomas, ameloblastic/fibrodentinomas, odontomas and pericoronary caps. AF: Ameloblastic fibroma; AFD: Ameloblastic fibrodentinoma; AFO: Ameloblastic fibro-odontoma; O: Odontoma; PC: Pericoronary cap; OT: Odontogenic tumors; Cx-43: Connexin-43; Cav-1: Caveolin-1.

Table 2 Mixed-effects logistic regression model

Variable	LRT	gL	P value	OR
OT	15	3	0.0020b
Biomarker	17	3	< 0.0010c
Sex	0	1	0.9720
Age	6	1	0.0110a	0.93

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

Model used to compare the behavior of biomarkers according to the variable: Type of neoplasia (ameloblastic fibrodentinoma/ameloblastic fibro-odontoma, ameloblastic fibroma, odontoma, pericoronary caps); sex; and age. Only the factors affecting the expression of biomarkers are shown. OT: Odontogenic tumor; LRT: Likelihood ratio test statistic; OR: Odds ratio.

Table 3 Post-hoc multiple comparisons of immunohistochemical expression

Sample	Expression, %	95%CI	P value, compared with O	P value, compared with AF
O	12	(2.9-37.9)	-	0.008b
PC	19	(3.6-57.7)	0.973	0.092
AFO/AFD	72	(38.5-91.5)	0.025a	0.984
AF	78	(51.5-92.5)	0.008b	-

^aP < 0.05.

^bP < 0.01.

Post-hoc multiple comparisons of expressions in ameloblastic fibroma, ameloblastic fibrodentinoma/ameloblastic fibro-odontoma, odontoma, and pericoronary cap, considering the variables age, sex, and location. The degree of similarity in immunohistochemical expression is described. AF: Ameloblastic fibroma; AFD: Ameloblastic fibrodentinoma; AFO: Ameloblastic fibro-odontoma; CI: Confidence interval; O: Odontoma; PC: Pericoronary cap.