Experimental beneficial effect of rosuvastatin on burn wound healing in a rat model

Table 1 Descriptive statistics analysis of C-reactive protein changes by rat group and day of sacrifice

Group	Day	mean	Range	Median	IQR	SD
Group placebo	3	18.22	5.85	18.26	1.56	3.85
Group control	3	21.04	1.77	21.10	0.82	4.22
Group study	3	15.29	5.29	15.52	1.70	4.52
Group placebo	6	13.71	5.65	13.40	1.24	3.85
Group control	6	16.53	6.40	16.57	1.59	4.22
Group study	6	10.74	4.37	10.48	2.00	4.52
Group placebo	9	9.63	2.06	9.42	1.30	3.85
Group control	9	11.35	4.52	11.48	0.87	4.22
Group study	9	4.89	3.43	4.98	1.66	4.52

IQR: Interquartile range.

Table 2 Descriptive statistics analysis of tumor necrosis factor-alpha changes by rat group and day of sacrifice

Group	Day	mean	Range	Median	IQR	SD
Group placebo	3	30.70	4.69	30.64	1.65	6.76
Group control	3	35.29	6.80	34.39	2.26	5.65
Group study	3	24.27	5.50	23.91	3.10	7.34
Group placebo	6	22.62	5.58	22.89	1.83	6.76
Group control	6	27.46	6.07	27.55	2.52	5.65
Group study	6	14.04	4.93	13.72	1.74	7.34
Group placebo	9	14.78	3.91	14.24	1.63	6.76
Group control	9	22.78	6.21	23.82	3.49	5.65
Group study	9	7.08	4.06	6.94	1.16	7.34

IQR: Interquartile range.

Table 3 Descriptive statistics analysis of interleukin-6 changes by rat group and day of sacrifice

Group	Day	mean	Range	Median	IQR	SD
Group placebo	3	35.56	6.00	35.52	3.62	7.72
Group control	3	40.24	6.17	39.37	2.99	6.25
Group study	3	30.53	5.21	30.87	0.71	8.50
Group placebo	6	27.08	6.54	27.75	2.77	7.72
Group control	6	34.49	5.58	34.11	2.40	6.25
Group study	6	19.36	5.63	19.56	1.45	8.50
Group placebo	9	17.73	7.43	17.82	3.19	7.72
Group control	9	25.87	4.44	25.72	1.99	6.25
Group study	9	10.40	4.30	10.25	1.75	8.50

IQR: Interquartile range.

Table 4 Descriptive statistics analysis of burn wound size changes by rat group and day of sacrifice

Group	Day	mean	Range	Median	IQR	SD
Group placebo	3	219.31	18.77	217.29	6.66	34.53
Group control	3	235.17	25.88	236.17	5.08	31.40
Group study	3	204.65	57.20	207.37	13.06	44.26
Group placebo	6	179.29	34.08	179.73	20.22	34.53
Group control	6	203.70	35.32	203.36	14.04	31.40
Group study	6	152.17	19.42	155.25	8.73	44.26
Group placebo	9	139.16	29.02	139.29	13.26	34.53
Group control	9	163.55	38.28	164.22	9.25	31.40
Group study	9	101.33	34.99	99.85	8.05	44.26

IQR: Interquartile range.

Table 5 Coefficients of the inflammatory Infiltration model: Regression analysis results

Predictor	Coefficient (β)	SE	t value	P value
Group study	-20.9163	0.3231	-64.73	< 0.001
Group placebo	-0.4418	0.9449	-0.47	0.640
Day 6	1.7917	1.0206	1.76	0.079
Day 9	1.2528	0.9449	1.33	0.185
Group study × day 6	-3.5835	1.6030	-2.24	0.025
Group study × day 9	-21.1606	Approximately 0.0000	-3.94e + 08	< 0.001
Group placebo × day 6	-0.9444	1.3849	-0.68	0.495
Group placebo × day 9	0.9808	1.4121	0.69	0.487
Cut-point 0|1	-20.5108	0.3224	-63.62	< 0.001
Cut-point 1|2	0.4055	0.6455	0.63	0.530

Table 6 Coefficients of the neovascularization model: Regression analysis results

Predictor	Coefficient (β)	SE	t value	P value
Group study	2.3072	0.9218	2.50	0.012
Group placebo	0.3138	0.8292	0.38	0.705
Day 6	-0.7534	0.9046	-0.83	0.405
Day 9	-1.2683	0.9872	-1.28	0.199
Group study × day 6	3.0884	1.5367	2.01	0.044
Group study × day 9	2.9249	1.4193	2.06	0.039
Group placebo × day 6	1.7872	1.2369	1.44	0.148
Group placebo × day 9	1.3427	1.3110	1.02	0.306
Cut-point 0|1	0.1451	0.5973	0.24	0.808
Cut-point 1|2	2.5504	0.7012	3.64	< 0.001

Table 7 Coefficients of the fibroblastic response model: Regression analysis results

Predictor	Coefficient (β)	SE	t value	P value
Group study	2.0683	0.9107	2.27	0.023
Group placebo	0.2975	0.8148	0.37	0.715
Day 6	-0.6730	0.8562	-0.79	0.432
Day 9	-1.0816	0.8970	-1.21	0.228
Group study × day 6	3.0282	1.5111	2.00	0.045
Group study × day 9	3.5531	1.5307	2.32	0.020
Group placebo × day 6	1.7481	1.2163	1.44	0.151
Group placebo × day 9	1.2231	1.2378	0.99	0.323
Cut-point 0|1	-0.1883	0.5850	-0.32	0.748
Cut-point 1|2	2.3328	0.6766	3.45	< 0.001