Neurobiological mechanisms linking vitamin d signaling to cognitive decline and neurodegeneration: Untangling epidemiology, pathophysiology, and evidence

doi:10.5493/wjem.v16.i1.118761

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Exp Med. Mar 20, 2026; 16(1): 118761
Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.118761

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Figure 1 Overview of vitamin D metabolism.

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Figure 2 Vitamin D/vitamin D receptor signaling pathways in neuroprotection.

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Figure 3 Anti-inflammatory and antioxidant effects of vitamin D.

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Figure 4 Role of vitamin D in blood-brain barrier showing how it can impact proteins or molecules that regulates cerebral perfusion. VDR: Vitamin D receptor; BBB: Blood-brain barrier.

Citation: Choudhary N, Zahid M, Ahmad M, Shaukat M, Tariq M, Rajeshwara S, Usman S, Wajid T, Awosika A. Neurobiological mechanisms linking vitamin d signaling to cognitive decline and neurodegeneration: Untangling epidemiology, pathophysiology, and evidence. World J Exp Med 2026; 16(1): 118761
URL: https://www.wjgnet.com/2220-315x/full/v16/i1/118761.htm
DOI: https://dx.doi.org/10.5493/wjem.v16.i1.118761