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Contents Volume 16 Issue 12 December 24, 2025

Editorial

Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade

Gizem Calibasi-Kocal

World J Clin Oncol 16(12):114275. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.114275

Abstract (40) | Core Tip (50) | Full Article (HTML) (315) | Full Article (PDF)-376K (55) | Full Article with Cover (PDF)-662K (18) | Full Article (XML)-66K (26) | Audio-881K (8) | Peer-Review Report-195K (21) | Answering Reviewers-179K (22) | Received: 09/14/2025 | Revised: 10/06/2025 | Accepted: 12/19/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1026) | Similar Articles (81) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Reader Comments (1) | Cite |

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Review

Pathogenicity of Helicobacter pylori-associated gastric cancer

Shamshul Ansari, Nada Ahmed

World J Clin Oncol 16(12):110909. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.110909

Abstract (45) | Core Tip (45) | Full Article (HTML) (488) | Figures (1-1) (42) | Full Article (PDF)-1718K (170) | Full Article with Cover (PDF)-2001K (27) | Full Article (XML)-338K (26) | Audio-565K (13) | Peer-Review Report-362K (32) | Answering Reviewers-186K (22) | Received: 06/17/2025 | Revised: 08/01/2025 | Accepted: 11/13/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (1891) | Similar Articles (1283) | Timeline of Article Publication (3) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Liquid biopsy in genitourinary cancers: Diagnostic and prognostic implications

Joe Youssef, Amani Yehya, Zahraa Salhab, Ricardo Bitar, Fatima Ghamlouche, Hisham F Bahmad, Wassim Abou-Kheir

World J Clin Oncol 16(12):113578. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.113578

Abstract (49) | Core Tip (46) | Full Article (HTML) (308) | Figures (1-1) (43) | Tables (1-1) (45) | Full Article (PDF)-806K (168) | Full Article with Cover (PDF)-1091K (76) | Full Article (XML)-337K (25) | Audio-717K (10) | Peer-Review Report-250K (21) | Answering Reviewers-66K (21) | Received: 09/01/2025 | Revised: 09/30/2025 | Accepted: 11/10/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (1564) | Similar Articles (17) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Minireviews

Immune therapy-related hyperprogressive disease: Molecular mechanisms, biomarkers, and clinical strategies

Xiao-Ming Zhang, Fei-Yu Zhao, Lin-Feng Gao, Tao Xu, Fan Yang, Nian-Song Qian

World J Clin Oncol 16(12):110351. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.110351

Abstract (46) | Core Tip (40) | Full Article (HTML) (227) | Figures (1-1) (42) | Tables (1-2) (46) | Full Article (PDF)-1845K (167) | Full Article with Cover (PDF)-2129K (49) | Full Article (XML)-238K (29) | Audio-1189K (17) | Peer-Review Report-230K (22) | Answering Reviewers-39K (36) | Received: 06/04/2025 | Revised: 07/05/2025 | Accepted: 11/11/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1171) | Similar Articles (0) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Perioperative immunotherapy in gastric cancer in the spotlight

Laura S Pernomian, Maria Fernanda Teixeira, Raphael LC Araujo, Pedro Luiz Serrano Uson Junior

World J Clin Oncol 16(12):110988. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.110988

Abstract (64) | Core Tip (46) | Full Article (HTML) (341) | Tables (1-5) (53) | Full Article (PDF)-529K (128) | Full Article with Cover (PDF)-814K (347) | Full Article (XML)-257K (21) | Audio-624K (4) | Peer-Review Report-228K (29) | Answering Reviewers-500K (20) | Received: 06/20/2025 | Revised: 07/27/2025 | Accepted: 11/14/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1505) | Similar Articles (1404) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Provoking myofibroblast death: Strategies to resolve fibrosis and remodel tumor microenvironment

Ganapasam Sudhandiran, Thangavelu Shalini

World J Clin Oncol 16(12):111086. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.111086

Abstract (46) | Core Tip (50) | Full Article (HTML) (238) | Figures (1-2) (41) | Tables (1-1) (45) | Full Article (PDF)-2387K (117) | Full Article with Cover (PDF)-2671K (139) | Full Article (XML)-199K (25) | Audio-1077K (12) | Peer-Review Report-282K (21) | Answering Reviewers-42K (21) | Received: 06/22/2025 | Revised: 07/28/2025 | Accepted: 11/13/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1600) | Similar Articles (21) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Relevance and application of sirtuin 3-activated mitophagy in gastric cancer treatment

Hao-Yu Zhao, Chu-Ying Yu, Xin-Tong Ye, Su-Ting Qian, Ye Huang, Qing-Sheng Liu

World J Clin Oncol 16(12):111175. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.111175

Abstract (48) | Core Tip (45) | Full Article (HTML) (161) | Figures (1-5) (39) | Full Article (PDF)-3139K (78) | Full Article with Cover (PDF)-3421K (21) | Full Article (XML)-142K (21) | Audio-18451K (6) | Peer-Review Report-488K (19) | Answering Reviewers-67K (16) | Received: 06/25/2025 | Revised: 08/14/2025 | Accepted: 11/13/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (923) | Similar Articles (1294) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Ultra-processed foods and dietary habits of oncology patients: Risk factor or survival strategy

Balint Madarasz, Mate Adam Balazs, Erzsebet Palfi, Julia Konczos, Andrea Toth, Gyongyver Szentmartoni, Zoltan Herold, Magdolna Dank

World J Clin Oncol 16(12):111372. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.111372

Abstract (44) | Core Tip (42) | Full Article (HTML) (287) | Figures (1-1) (39) | Tables (1-1) (44) | Full Article (PDF)-1952K (56) | Full Article with Cover (PDF)-2237K (156) | Full Article (XML)-123K (26) | Audio-704K (3) | Peer-Review Report-256K (23) | Answering Reviewers-86K (21) | Received: 06/27/2025 | Revised: 07/29/2025 | Accepted: 11/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1230) | Similar Articles (1) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Metabolic syndrome and colorectal cancer: Mechanisms, epidemiological evidence, and clinical implications

Fei Gao, Yan Jiao, He-Lei Wang

World J Clin Oncol 16(12):112639. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.112639

Abstract (62) | Core Tip (47) | Full Article (HTML) (248) | Figures (1-1) (35) | Tables (1-1) (37) | Full Article (PDF)-694K (53) | Full Article with Cover (PDF)-980K (19) | Full Article (XML)-57K (24) | Audio-1132K (15) | Peer-Review Report-225K (21) | Answering Reviewers-67K (18) | Received: 08/01/2025 | Revised: 09/04/2025 | Accepted: 11/14/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1089) | Similar Articles (1229) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Advances in prostate cancer treatment with moderate and ultra-hypofractionated radiotherapy

Ling-Ling Meng, Yu-Peng Di, Lin Ma, Bao-Lin Qu

World J Clin Oncol 16(12):112735. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.112735

Abstract (50) | Core Tip (38) | Full Article (HTML) (356) | Figures (1-1) (39) | Tables (1-1) (58) | Full Article (PDF)-1270K (55) | Full Article with Cover (PDF)-1553K (145) | Full Article (XML)-146K (24) | Audio-984K (12) | Peer-Review Report-195K (22) | Answering Reviewers-202K (27) | Received: 08/04/2025 | Revised: 09/15/2025 | Accepted: 11/17/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1294) | Similar Articles (69) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Case Control Study

Group-specific component and 25-hydroxylase gene polymorphisms in nasopharyngeal carcinoma: Associations with susceptibility and radiotherapy response

Liu Liu, Dian-Yu Shi, Jie Tan, Shan Xu, Chao-Ran Liu

World J Clin Oncol 16(12):111544. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.111544

Abstract (40) | Core Tip (46) | Full Article (HTML) (185) | Figures (1-2) (36) | Tables (1-4) (42) | Full Article (PDF)-1789K (39) | Full Article with Cover (PDF)-2073K (59) | Full Article (XML)-132K (23) | Audio-147K (8) | Peer-Review Report-454K (26) | Answering Reviewers-387K (16) | Received: 07/08/2025 | Revised: 08/19/2025 | Accepted: 11/13/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1648) | Similar Articles (22) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Retrospective Cohort Study

Expanding the role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A multicenter study on uncommon peritoneal malignancies

Massimo Framarini, Fabrizio D'Acapito, Piero Vincenzo Lippolis, Andrea Di Giorgio, Daniela Di Pietrantonio, Antonio Sommariva, Paolo Sammartino

World J Clin Oncol 16(12):112443. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.112443

Abstract (50) | Core Tip (42) | Full Article (HTML) (289) | Figures (1-4) (42) | Tables (1-3) (42) | Full Article (PDF)-1193K (53) | Full Article with Cover (PDF)-1478K (17) | Full Article (XML)-163K (20) | Audio-803K (6) | Peer-Review Report-227K (18) | Answering Reviewers-197K (15) | Received: 07/27/2025 | Revised: 09/01/2025 | Accepted: 11/07/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1183) | Similar Articles (44) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Retrospective Study

Stem cell collection from peripheral blood of multiple myeloma patients

Jonah Lee, Quincy Seigel, Spencer Lee, Emily Green, Sara Chitlik, Veronika Lobova, Paul Eastvold, Chris Gresens, Erin A Kaya

World J Clin Oncol 16(12):103683. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.103683

Abstract (46) | Core Tip (41) | Full Article (HTML) (187) | Tables (1-5) (41) | Full Article (PDF)-399K (35) | Full Article with Cover (PDF)-685K (25) | Full Article (XML)-75K (21) | Audio-334K (6) | Peer-Review Report-193K (18) | Answering Reviewers-61K (14) | Received: 11/27/2024 | Revised: 03/09/2025 | Accepted: 11/14/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (928) | Similar Articles (33) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Endoscopic submucosal dissection and hybrid endoscopic submucosal dissection for stage 1 rectal neuroendocrine tumors

Xue-Yan Qiao, Xiu-Jiao Shen, Yan-Hua Lv, Ruo-Bing Chen, Jun Weng, Guo-Liang Xu, Ge Wen, Kun-Hao Bai

World J Clin Oncol 16(12):112871. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.112871

Abstract (50) | Core Tip (48) | Full Article (HTML) (178) | Figures (1-1) (42) | Tables (1-5) (37) | Full Article (PDF)-500K (37) | Full Article with Cover (PDF)-784K (20) | Full Article (XML)-113K (22) | Audio-13512K (11) | Peer-Review Report-243K (22) | Answering Reviewers-109K (23) | Received: 08/07/2025 | Revised: 09/14/2025 | Accepted: 11/13/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1215) | Similar Articles (251) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Observational Study

Impact evaluation of intra-fractional variation on online adaptive radiotherapy for postoperative cervical and endometrial cancer

Guang-Yu Wang, Yi-Ning Chen, Yu-Liang Sun, Bing Zhou, Fu-Quan Zhang, Jun-Fang Yan, Ke Hu

World J Clin Oncol 16(12):111601. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.111601

Abstract (50) | Core Tip (43) | Full Article (HTML) (207) | Figures (1-2) (40) | Tables (1-2) (36) | Full Article (PDF)-2240K (43) | Full Article with Cover (PDF)-2526K (24) | Full Article (XML)-107K (23) | Audio-359K (13) | Peer-Review Report-290K (24) | Answering Reviewers-1210K (19) | Supplementary Material-72K (23) | Received: 07/04/2025 | Revised: 08/30/2025 | Accepted: 11/11/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1715) | Similar Articles (12) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Basic Study

Expression patterns and clinical implications of chaperonin subunit 3 mRNA and protein in laryngeal squamous cell carcinoma

Bin-Yu Mo, Jia-Ying Wen, Guo-Qiang Chen, Jing-Wen Ling, Han He, Zi-Li Qin, Fang-Yun Tian, Qi Li, Bin Li, Jian-Di Li, Rong-Quan He, Di-Yuan Qin, Zong-Yu Li, Gang Chen, Chao-Hua Mo, Chang Chen, Shi-Hua Yin, Li Yang

World J Clin Oncol 16(12):112161. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.112161

Abstract (46) | Core Tip (44) | Full Article (HTML) (222) | Figures (1-9) (39) | Tables (1-1) (42) | Full Article (PDF)-41056K (86) | Full Article with Cover (PDF)-41342K (37) | Full Article (XML)-124K (25) | Audio-289K (9) | Peer-Review Report-220K (28) | Answering Reviewers-1537K (25) | Supplementary Material-93K (23) | Received: 07/19/2025 | Revised: 09/13/2025 | Accepted: 11/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1221) | Similar Articles (0) | Timeline of Article Publication (4) | Article Quality Tracking (0) | Cite |

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Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in Helicobacter pylori-induced gastric cancer progression

Jing-Wan Chen, Jie-Ji Ouyang, Zhen-Hui Wang, Di-Meng Ma, Zhi Zhang, Qiong Teng, Gang Yu, Xiang-Yong Li

World J Clin Oncol 16(12):112626. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.112626

Abstract (44) | Core Tip (40) | Full Article (HTML) (268) | Figures (1-6) (46) | Tables (1-2) (40) | Full Article (PDF)-41240K (56) | Full Article with Cover (PDF)-41524K (90) | Full Article (XML)-150K (24) | Audio-315K (15) | Peer-Review Report-243K (20) | Answering Reviewers-114K (19) | Supplementary Material-256K (22) | Received: 08/01/2025 | Revised: 09/09/2025 | Accepted: 11/13/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1285) | Similar Articles (1311) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (1) | Cite |

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Case Report

Intrathyroidal thymic carcinoma comprising squamous cell and small cell carcinoma components: A case report

Bing-Wen Shan, Juan-Han Yu, Tong Ren

World J Clin Oncol 16(12):111701. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.111701

Abstract (46) | Core Tip (44) | Full Article (HTML) (169) | Figures (1-4) (47) | Full Article (PDF)-21804K (127) | Full Article with Cover (PDF)-22090K (19) | Full Article (XML)-47K (22) | Audio-1079K (9) | Peer-Review Report-227K (23) | Answering Reviewers-304K (22) | Received: 07/07/2025 | Revised: 08/24/2025 | Accepted: 11/14/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1084) | Similar Articles (4550) | Timeline of Article Publication (2) | Article Quality Tracking (0) | Cite |

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Radiotherapy for large ruptured hemorrhagic axillary lymph node metastasis from anaplastic lymphoma kinase-positive lung adenocarcinoma: A case report and review of literature

Zhi-Min Li, Yang-Chenxi Wang, Kai-Yue Wang, Ning-Jing Xie, Jun Zhou, Xiao-Na Chang, Quan Chen, Geng Wang, Sheng Zhang, Rui Zhou

World J Clin Oncol 16(12):112140. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.112140

Abstract (40) | Core Tip (36) | Full Article (HTML) (214) | Figures (1-5) (41) | Full Article (PDF)-2166K (44) | Full Article with Cover (PDF)-2449K (57) | Full Article (XML)-119K (27) | Audio-505K (10) | Peer-Review Report-198K (21) | Answering Reviewers-45K (17) | Supplementary Material-486K (19) | Received: 07/18/2025 | Revised: 08/20/2025 | Accepted: 11/07/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1086) | Similar Articles (4557) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Letter to the Editor

Ectonucleoside triphosphate diphosphohydrolase 6: A double-edged sword in cancer prognosis and therapy

Abdellatif Bouayad

World J Clin Oncol 16(12):115789. Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.115789

Abstract (45) | Core Tip (46) | Full Article (HTML) (166) | Figures (1-1) (42) | Full Article (PDF)-3294K (46) | Full Article with Cover (PDF)-3580K (16) | Full Article (XML)-34K (27) | Audio-229K (10) | Peer-Review Report-194K (17) | Answering Reviewers-131K (25) | Received: 10/25/2025 | Revised: 10/30/2025 | Accepted: 11/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (932) | Similar Articles (901) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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