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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 24, 2025; 16(12): 111544
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.111544
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.111544
Group-specific component and 25-hydroxylase gene polymorphisms in nasopharyngeal carcinoma: Associations with susceptibility and radiotherapy response
Liu Liu, Dian-Yu Shi, Jie Tan, Shan Xu, Chao-Ran Liu, Department of Otolaryngology-Head and Neck Surgery, Longhua District People's Hospital, Shenzhen 518110, Guangdong Province, China
Author contributions: Liu L, Shi DY, Tan J, and Xu S performed the research; Liu CR designed the research study; all of the authors read and approved the final version of the manuscript to be published.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Longhua District People's Hospital.
Informed consent statement: All participants provided informed consent.
Conflict-of-interest statement: No potential conflict of interest was reported by the authors.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Data sharing statement: The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao-Ran Liu, PhD, Researcher, Department of Otolaryngology-Head and Neck Surgery, Longhua District People's Hospital, No. 38 Jianshe East Road, Longhua District, Shenzhen 518110, Guangdong Province, China. chaoranliuszlhrmyy@163.com
Received: July 9, 2025
Revised: August 19, 2025
Accepted: November 13, 2025
Published online: December 24, 2025
Processing time: 168 Days and 3.5 Hours
Revised: August 19, 2025
Accepted: November 13, 2025
Published online: December 24, 2025
Processing time: 168 Days and 3.5 Hours
Core Tip
Core Tip: This study reveals that polymorphisms in the vitamin D-binding protein gene [group-specific component (GC), rs4588] and 25-hydroxylase gene (CYP2R1) (rs12794714) are associated with nasopharyngeal carcinoma (NPC) susceptibility and radiotherapy response, particularly in individuals with sufficient serum 25-hydroxyvitamin D levels. The GC rs4588 TT genotype increases NPC risk, while the CYP2R1 rs12794714 AA genotype predicts radiotherapy resistance. These findings highlight the interplay between genetic predisposition and vitamin D status, offering new strategies for precision prevention and personalized treatment in NPC.