World Journal of Clinical Oncology - Baishideng Publishing Group

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Type 2 diabetes exacerbates breast cancer progression through hyperglycaemia, impaired glucose tolerance and insulin resistance, driving a shift toward triple-negative subtypes while reducing human epidermal growth factor receptor 2-positive cases.

Diagram showing biological mechanisms of proposed insulin and insulin-like growth factor 1 induced carcinogenesis.

Immune suppression network in the tumor microenvironment of pancreatic ductal adenocarcinoma.

Immune cells in the tumor microenvironment.

Regulation of autophagy by glucose metabolism.

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Anlotinib plus albumin-bound paclitaxel induction-maintenance for sorafenib-refractory radioiodine-refractory differentiated thyroid cancer: A case report and review of literature

Featured Articles More >>

Anlotinib plus albumin-bound paclitaxel induction-maintenanc... 2026-05-20
Overexpression of low-molecular-weight caldesmon is associat... 2026-05-20
Integrated Chinese and Western medicine prolong survival in ... 2026-05-20
Integration of pathomics and single-cell omics in pancreatic... 2026-05-20
Diabetes mellitus and ovarian cancer: Intersecting pathways ... 2026-05-20

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World Journal of Clinical Oncology is an international, peer-reviewed, open-access academic journal dedicated to publishing original, high-quality research findings in the field of oncology, including clinical, translational, and basic studies, as well as research involving artificial intelligence. The journal focuses on, but is not limited to, the following areas: Biology of neoplasia, breast cancer, cancer prevention and control, cancer-related complications, diagnosis in oncology, gastrointestinal cancer, genetic testing for cancer, gynecologic cancer, head and neck cancer, hematologic malignancy, lung cancer, melanoma, molecular oncology, neurooncology, palliative and supportive care, pediatric oncology, surgical oncology, translational oncology, and urologic oncology. Types of articles published by the journal include clinical study, basic study, case report, editorial, review, minireview, systematic review, meta-analysis, guidelines, and correspondence. All submissions undergo a rigorous and transparent peer-review process by at least two independent reviewers. Manuscripts are evaluated based on scientific rigor, originality, clinical relevance, and reproducibility, with particular attention to methodological robustness and data integrity. Constructive and timely feedback is provided to ensure the highest standards of scholarly communication. The journal adheres to the highest standards of publication ethics and editorial integrity, in accordance with the guidelines of the Committee on Publication Ethics, the International Committee of Medical Journal Editors, and the World Association of Medical Editors. To advance scientific discovery, promote evidence-based clinical practice, and foster innovation in oncology, ultimately improving global health outcomes. We invite researchers, clinicians, and multidisciplinary experts worldwide to submit high-quality manuscripts and contribute to shaping the future of oncological science. Submit an Article >>

2026 Published Issues

5 4 3 2 1

Editors-in-Chief

Marina Pinheiro, Assistant Professor, (Email: marinabppinheiro@gmail.com) Unidade de Saúde Pública, Unidade Local de Saúde Barcelos/Esposende, Barcelinhos 4755-069, Braga, Portugal; Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Porto 4050-313, Portugal

Indexing/Abstracting

The WJCO is now abstracted and indexed in PubMed, PubMed Central, Emerging Sources Citation Index (ESCI, Web of Science), Reference Citation Analysis, China Science and Technology Journal Database, and Superstar Journals Database.

Journal Metrics

The 2025 edition of Journal Citation Reports® cites the 2024 journal impact factor (JIF) for WJCO as 3.2; JIF without journal self cites: 3.1; 5-year JIF: 3.2; JIF Rank: 129/326 in oncology; JIF Quartile: Q2; and 5-year JIF Quartile: Q2.

ISSN

2218-4333 (online)

Latest Manuscript Statistics

Received (2263), Duration of Peer Review (25 days/Mean), Days from Submission to First Decision (51 days/Mean), Second Decision Time (41 days/Mean), Accepted (52.8%/Mean), Production Time (46 days/Mean), Time to Publication (171 days/Mean), and Rejected (34.2%/Mean).

Current Issue

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Contents Volume 17 Issue 5 May 24, 2026

Editorial

Immune checkpoint co-expression combined with systemic inflammatory index: A promising approach in prognostic evaluation of lymphoma in Egypt

Zu-Chian Chiang, Ji-Zhen Lin, Qi Chen

World J Clin Oncol 17(5):117391. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.117391

Evidence Review

Role of lactylation in tumorigenesis: Analysis based on the ten hallmarks of cancer

Jin-Hao Chen, Jiang-Qiuchen Wu, Cun-Ming Lv

World J Clin Oncol 17(5):113527. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.113527

Minireviews

Diabetes mellitus and ovarian cancer: Intersecting pathways and clinical outcomes

Tirath Patel, Sara Kareem Ali, Yusur Jawad, Seba Hasan Haddad, Liyan Mahmoud Al Masri, Aya Rimawi, Reem Ahmed Alraeesi, Hessah Sultan Alkaabi, Muhammad Farhan, Maheen Zahid, Muhammad Ahmad, Neha Choudhary, Muhammad Hashir Nazir, Ayoola Awosika

World J Clin Oncol 17(5):117365. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.117365

DNA methylation in gastric precancerous lesions: Molecular mechanisms and clinical translation

Si-Hui Zeng, Yu-Qi Wu, Wei-Jian Zhang, Yi-Tian Wang, Lin Xu, Shao-Ju Guo

World J Clin Oncol 17(5):118073. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.118073

Immunomodulatory and antitumor effects of shilajit and glycine: Natural metabolic modulators targeting breast and liver cancer

Tasneem A Basbrain, Nidal M Zabermawi, Jehan S Alrahimi, Kawther A Zaher

World J Clin Oncol 17(5):119163. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.119163

Integration of pathomics and single-cell omics in pancreatic ductal adenocarcinoma: Applications and clinical translation prospects

Xin Yan, Hong-Yu Xu, Jia-Wu Liu, Zhi-Yong Yang, Qian Zhu

World J Clin Oncol 17(5):119864. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.119864

Case Control Study

Prognostic value of lung immune prognostic index in stage I non-small cell lung cancer treated with stereotactic body radiotherapy: A two-center study

Wei-Hua Gao, Hui Luo, Qing-Yao Zhu, Qiang Jiang, Li-Xia Lian

World J Clin Oncol 17(5):120140. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.120140

Retrospective Cohort Study

Integrated Chinese and Western medicine prolong survival in colorectal cancer with liver metastasis: A retrospective cohort study

Jiang-Yu Bian, Yu-Xing Sun, Lin-Feng Wang, Wen-Ting He, Chuan-Bo Liu, Xue-Qian Wang, Tong Zhang

World J Clin Oncol 17(5):118265. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.118265

Retrospective Study

Hepatic resection in adolescent and young adult patients with hepatocellular carcinoma

Junji Ueda, Nobuhiko Taniai, Masato Yoshioka, Akira Matsushita, Satoshi Mizutani, Yoichi Kawano, Tetsuya Shimizu, Tomohiro Kanda, Takahiro Murokawa, Hideyuki Takata, Hiroyasu Furuki, Yuto Aoki, Mampei Kawashima, Toshiyuki Irie, Takashi Ono, Takahiro Haruna, Daigo Yoshimori, Kazuhiko Endo, Akira Hamaguchi, Hiroshi Yoshida

World J Clin Oncol 17(5):117168. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.117168

Comparison of dagnostic performance between senior and junior radiologists using subjective assessment vs ovarian-adnexal reporting and data system

Hui-Ping Zhang, Quan Zhu, Jing-Jing Wu, An-Qiang Yang, Tian-Tian Chen, Juan Zhang, Yu-Qing Zhou

World J Clin Oncol 17(5):119512. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.119512

Observational Study

Psychological flexibility and coping behaviors in cervical cancer patients: Moderating role of illness perception

Yan-Fei Di, Zhen Zhang, Qian Li, Xue Han, Qin Chen, Xin-Ying He, Peng-Fei Xu, Hai-Xiang Wang

World J Clin Oncol 17(5):120810. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.120810

Prospective Study

Clinicopathological and prognostic relevance of nestin in low- and high-grade gliomas: An immunohistochemical study

Sabeen Nasir, Asif Ali, Ihsan Ullah, Shabnam Wazir, Irum Javaid, Summaya Z Jalal, Ishaq Khan, Muhammed Mubarak

World J Clin Oncol 17(5):118350. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.118350

Basic Study

Overexpression of low-molecular-weight caldesmon is associated with aggressive phenotypes and epithelial-mesenchymal transition in breast cancer cells

Alya AlNuaimi, Vidhya A Nair, Noura Al-Khayyal, Ashna Suliman, Lara J Bou Malhab, Rifat Hamoudi, Mohamad Hamad, Iman M Talaat, Wael M Abdel-Rahman

World J Clin Oncol 17(5):116662. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.116662

Identification of SRSF2 as a potential immunodiagnostic biomarker for osteosarcoma: A study based on focused protein microarray

Yan Ma, Lei Wan, Yong-Yong Zhang, Ya-Ge Luo, Ning Yang, Fei-Fei Pu, Malik Ihsan Ullah Khan, Man Liu, Jin-Shan Liu, Ji-Tian Li

World J Clin Oncol 17(5):119275. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.119275

Meta-Analysis

Impact of surgery for colorectal cancer liver metastasis: Systematic review and meta-analysis

Fausto Petrelli, Sara Cherri, Antonio Ghidini, Mauro Rossitto, Roberta Bukovec, Luisa Roncari, Lorenzo Dottorini, Marcella Arru, Michela Libertini, Alberto Zaniboni

World J Clin Oncol 17(5):118670. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.118670

Intracystic glucose is superior to carcinoembryonic antigen in diagnosing mucinous pancreatic cysts in genomic era: Systematic review and meta-analysis

Giacomo Emanuele Maria Rizzo, Giuseppe Infantino, Giovanni Marchegiani, Jorge D Machicado, Marco Del Chiaro, Ilaria Tarantino, Gemma Rossi, Paolo Giorgio Arcidiacono, Giuseppe Vanella, Lucia Guilabert, Sara Nikolić, Gabriele Capurso

World J Clin Oncol 17(5):120600. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.120600

Case Report

Clinical presentation and management of hereditary gingival fibromatosis: Four case reports

Yuan Cheng, Jie Zhao, Jie Yang, Liang-Yuan Lin, Juan Wu

World J Clin Oncol 17(5):119443. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.119443

Anlotinib plus albumin-bound paclitaxel induction-maintenance for sorafenib-refractory radioiodine-refractory differentiated thyroid cancer: A case report and review of literature

Chun-Yan Zhou, Xin-Yi Ren, Huan-Huan Li, Xiao-Mei Pan, Xin Lan, Dong Duan

World J Clin Oncol 17(5):119615. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.119615

Abdominal nodal metastasis from an unknown primary: A case report and review of literature

Yi Lu, Qi Zhu, Yao Xiao, Ru-Yan Pan, Ling-Hui Deng, Qi Zhang, Yue Wang

World J Clin Oncol 17(5):120273. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.120273

Correspondence

Letter to the Editor: Revisiting the anatomical pattern of bone metastases in stage IV breast cancer: Missing clinical stratification and biological depth

Pei-Zhi Zhang, Yan-Jie Wang, Ying-Kun Xu

World J Clin Oncol 17(5):114734. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.114734

Letter to the Editor: Deep margin positivity in small rectal neuroendocrine tumors - pathological insights for post-endoscopic submucosal dissection management

Ling-Feng Zou, Yan Luo, Cheng-Long Wang

World J Clin Oncol 17(5):117161. Published online May 24, 2026. doi: 10.5306/wjco.v17.i5.117161