Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in Helicobacter pylori-induced gastric cancer progression

Table 1 Clinicopathological parameters in gastric cancer patients, n (%)

Parameter	YY1		χ²	P value
	High expression	Low expression
Gender
Male	54 (77.1)	22 (71)	0.440	0.507
Female	16 (22.9)	9 (29)	-	-
Age (years)
< 61	12 (17.1)	8 (25.8)	1.015	0.314
≥ 61	58 (82.9)	23 (74.2)	-	-
Tumor location
Upper	51 (72.9)	24 (77.4)	0.234	0.629
Middle + lower	19 (27.1)	7 (22.6)	-	-
Tumor size (cm)
< 6 cm	45 (64.3)	21 (67.7)	0.113	0.736
≥ 6 cm	25 (35.7)	10 (32.3)	-	-
Tumor differentiation
Well + moderate	8 (11.4)	11 (40.8)	8.140	0.004
Poor + undifferentiated	62 (88.6)	20 (59.2)	-	-
Lymph nodes metastasis	58 (84.1)	13 (41.9)	17.231	< 0.001
pTNM stage
I + II	31 (44.3)	24 (77.4)	9.510	0.002
III + IV	39 (55.7)	7 (22.6)

YY1: Yin Yang 1; pTNM: Pathologic tumor-node-metastasis.

Table 2 Univariate and multivariate survival analyses for association between clinicopathological parameters and YY1 expression

Parameter	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Gender (male vs female)	1.036 (0.592-1.815)	0.901	-	-
Age (< 60 years vs ≥ 60 years)	0.882 (0.496-1.567)	0.668	-	-
Tumor location (upper vs middle + lower)	0.837 (0.478-1.467)	0.535	-	-
Tumor size (< 6 cm vs ≥ 6 cm)	1.344 (0.820-2.202)	0.241	-	-
Differentiation (well + moderate vs poor + undifferentiated)	3.338 (1.744-6.387)	< 0.001	2.152 (1.108-4.181)	0.024
pT stage (T1-T2 vs T3-T4)	4.821 (2.292-10.138)	< 0.001	2.568 (1.169-5.642)	0.019
Lymph node metastasis (absent vs present)	4.682 (2.378-9.219)	< 0.001	3.067 (1.493-6.300)	0.002
pTNM stage (I-II vs III-IV)	3.818 (2.330-6.255)	< 0.001	2.211 (1.306-3.724)	0.003
YY1 expression (low vs high)	1.966 (1.106-3.495)	0.021	1.315 (1.054-1.552)	0.045

HR: Hazard ratio; CI: Confidence interval; YY1: Yin Yang 1; pTNM: Pathologic tumor-node-metastasis.