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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 24, 2025; 16(12): 112626
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.112626
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.112626
Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in Helicobacter pylori-induced gastric cancer progression
Jing-Wan Chen, Zhen-Hui Wang, Di-Meng Ma, Zhi Zhang, Qiong Teng, Xiang-Yong Li, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Jing-Wan Chen, Jie-Ji Ouyang, Gang Yu, Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China
Co-first authors: Jing-Wan Chen and Jie-Ji Ouyang.
Co-corresponding authors: Gang Yu and Xiang-Yong Li.
Author contributions: Chen WJ, Ouyang JJ, and Yu G were responsible for manuscript writing; Chen JW and Ouyang JJ contributed equally to this article as the co-first authors; Wang ZH and Ma MD were responsible for assistance in cell function experiments and clinical data compilation; Zhang Z and Teng Q were responsible for clinical data collection and analysis; Yu G and Li XY were responsible for concept and design and supervision, and they contributed equally to this article as the co-corresponding authors; and all authors have read and approved the manuscript.
Supported by the National Natural Science Foundation of China, No. 82372646; and Research Fund of Anhui Institute of Translational Medicine, No. 2023zhyx-C70 and No. 2023zhyx-C80.
Institutional review board statement: This study was approved by the Medical Ethics Committee of The Anhui Medical University (approval No. 20180323).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of The Anhui Medical University (approval No. LLSC20180345).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiang-Yong Li, PhD, Chief Physician, Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230022, Anhui Province, China. liyongxiang@ahmu.edu.cn
Received: August 4, 2025
Revised: September 9, 2025
Accepted: November 13, 2025
Published online: December 24, 2025
Processing time: 143 Days and 23.7 Hours
Revised: September 9, 2025
Accepted: November 13, 2025
Published online: December 24, 2025
Processing time: 143 Days and 23.7 Hours
Core Tip
Core Tip: This study revealed that Yin Yang 1 (YY1) was upregulated in Helicobacter pylori-induced gastritis and gastric cancer, where it promoted tumor proliferation, invasion, epithelial-mesenchymal transition, and growth by directly activating Janus kinase 2 transcription and enhancing Janus kinase 2/signal transducer and activator of transcription 3 phosphorylation. YY1 knockdown or pharmacological inhibition reversed these malignant phenotypes. These findings elucidate a key mech