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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 24, 2025; 16(12): 113578
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.113578
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.113578
Liquid biopsy in genitourinary cancers: Diagnostic and prognostic implications
Joe Youssef, Amani Yehya, Zahraa Salhab, Ricardo Bitar, Fatima Ghamlouche, Wassim Abou-Kheir, Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut 1107-2020, Lebanon
Hisham F Bahmad, Department of Pathology and Laboratory Medicine, University of Miami, Miller School of Medicine, Miami Beach, FL 33136, United States
Co-corresponding authors: Hisham F Bahmad and Wassim Abou-Kheir.
Author contributions: Youssef J, Yehya A, Salhab Z, Bitar R, and Ghamlouche F contributed investigation, methodology, and wrote the original draft; Youssef J, Bahmad HF, and Abou-Kheir W contributed to conceptualization and visualization; Youssef J, Yehya A, Salhab Z, Bitar R, Ghamlouche F, Bahmad HF, and Abou-Kheir W contributed to validation, reviewed and edited the manuscript; Bahmad HF and Abou-Kheir W contributed to project administration, supervision, gave final approval, and made equal contributions as co-corresponding authors; all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wassim Abou-Kheir, PhD, Full Professor, Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Bliss Street, Hamra, Beirut 1107-2020, Lebanon. wa12@aub.edu.lb
Received: September 2, 2025
Revised: September 30, 2025
Accepted: November 10, 2025
Published online: December 24, 2025
Processing time: 112 Days and 12.8 Hours
Revised: September 30, 2025
Accepted: November 10, 2025
Published online: December 24, 2025
Processing time: 112 Days and 12.8 Hours
Core Tip
Core Tip: Liquid biopsy (LB) is emerging as a new tool to help the oncologist for early screening and prognostication. The diagnostic accuracy of the different LB modalities is improving with newer techniques, showing promises in the future for early detection of malignancies. In specific, genitourinary cancers can be screened and followed up through urine LB, offering a non-invasive longitudinal tool for patient monitoring. LB offers new ways to predict disease progression, treatment response and early recurrence, reshaping the future of oncology.