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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 24, 2025; 16(12): 111701
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.111701
Published online Dec 24, 2025. doi: 10.5306/wjco.v16.i12.111701
Intrathyroidal thymic carcinoma comprising squamous cell and small cell carcinoma components: A case report
Bing-Wen Shan, Juan-Han Yu, Tong Ren, Department of Pathology, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Shan BW drafting and critical revision; Shan BW and Yu JH conception and design of study; Ren T collecting data and critical revision; Yu JH approval of final version of manuscript. All authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Juan-Han Yu, MD, Associate Professor, Department of Pathology, The First Hospital of China Medical University, No. 155 Nanjing Bei Ave, Shenyang 110001, Liaoning Province, China. yujuanhan@foxmail.com
Received: July 8, 2025
Revised: August 24, 2025
Accepted: November 14, 2025
Published online: December 24, 2025
Processing time: 169 Days and 10.5 Hours
Revised: August 24, 2025
Accepted: November 14, 2025
Published online: December 24, 2025
Processing time: 169 Days and 10.5 Hours
Core Tip
Core Tip: Intrathyroidal thymic carcinoma (ITC) is a rare malignant epithelial tumour of thymic origin occurring within the thyroid. ITC with both squamous cell and small cell carcinoma components has not been reported to date. This case report provides information on the microscopic morphological features of ITC with both squamous cell and small cell carcinoma components, and new potential evidence for the origin of ITC. As cluster of differentiation 117+ immunophenotype is a critical clue that should prompt consideration of ITC, which requires a different diagnostic and therapeutic approach than metastatic small cell lung cancer.