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Contents Volume 16 Issue 10 October 24, 2025

Editorial

From infection to invasion: The role of deleted in malignant brain tumors 1 in Helicobacter pylori-driven gastric cancer

Ionut Negoi

World J Clin Oncol 16(10):108377. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.108377

Abstract (77) | Core Tip (51) | Full Article (HTML) (200) | Figures (1-1) (44) | Tables (1-1) (46) | Full Article (PDF)-1279K (91) | Full Article with Cover (PDF)-1632K (121) | Full Article (XML)-109K (28) | Audio-559K (9) | Peer-Review Report-238K (24) | Answering Reviewers-246K (28) | Supplementary Material-286K (30) | Received: 04/11/2025 | Revised: 05/24/2025 | Accepted: 09/02/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2048) | Similar Articles (1387) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Novel approach to risk stratification: Integrating waist-hip ratio for predicting advanced colorectal neoplasia

Arvind Mukundan, Devansh Gupta, Riya Karmakar, Hsiang-Chen Wang

World J Clin Oncol 16(10):109843. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.109843

Abstract (66) | Core Tip (58) | Full Article (HTML) (305) | Full Article (PDF)-369K (69) | Full Article with Cover (PDF)-724K (80) | Full Article (XML)-42K (30) | Audio-357K (10) | Peer-Review Report-253K (35) | Answering Reviewers-163K (29) | Received: 05/23/2025 | Revised: 07/03/2025 | Accepted: 08/08/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1359) | Similar Articles (2) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Charged multivesicular body protein 7 as a prognostic biomarker in colorectal cancer metastasis

Mesut Tez

World J Clin Oncol 16(10):110056. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.110056

Abstract (66) | Core Tip (61) | Full Article (HTML) (246) | Tables (1-1) (53) | Full Article (PDF)-386K (63) | Full Article with Cover (PDF)-739K (87) | Full Article (XML)-63K (38) | Audio-78K (8) | Peer-Review Report-461K (33) | Answering Reviewers-41K (32) | Received: 05/28/2025 | Revised: 06/05/2025 | Accepted: 07/17/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1415) | Similar Articles (1286) | Timeline of Article Publication (1) | Article Quality Tracking (0) | Cite |

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Review

Oncogenic B-Raf proto-oncogene, serine/threonine kinase-mediated hedgehog signalling in the pathogenesis and targeted therapy of melanoma

Rafiq A Rather

World J Clin Oncol 16(10):105117. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.105117

Abstract (84) | Core Tip (52) | Full Article (HTML) (313) | Figures (1-1) (48) | Tables (1-2) (48) | Full Article (PDF)-1481K (85) | Full Article with Cover (PDF)-1833K (167) | Full Article (XML)-453K (28) | Audio-333K (11) | Peer-Review Report-330K (49) | Answering Reviewers-151K (36) | Received: 01/11/2025 | Revised: 05/26/2025 | Accepted: 09/03/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1539) | Similar Articles (62) | Timeline of Article Publication (1) | Authors Evaluation (2) | Article Quality Tracking (0) | Cite |

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Circulating tumor DNA in biliary tract cancers: A review of current applications

Maria Fernanda Teixeira, Mitesh Borad, Pedro Luiz Serrano Uson Junior

World J Clin Oncol 16(10):107875. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.107875

Abstract (93) | Core Tip (80) | Full Article (HTML) (352) | Tables (1-3) (51) | Full Article (PDF)-534K (81) | Full Article with Cover (PDF)-887K (37) | Full Article (XML)-324K (32) | Audio-309K (34) | Peer-Review Report-337K (28) | Answering Reviewers-382K (114) | Received: 03/29/2025 | Revised: 05/29/2025 | Accepted: 09/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (1376) | Similar Articles (28) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Gut microbiome and nutritional strategies in gastrointestinal cancers: Clinical implications and therapeutic perspectives

Vilma Pacheco-Barcia, Axel Mariño-Mendez, Enrique Hernandez-Jimenez, Paula Jimenez-Fonseca, Andrés Jesús Muñoz Martín, Sara Custodio-Cabello, Magda Palka-Kotlowska, Ivan Gonzalez-Diaz, Luis Cabezon-Gutierrez

World J Clin Oncol 16(10):107877. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.107877

Abstract (82) | Core Tip (76) | Full Article (HTML) (511) | Figures (1-2) (58) | Tables (1-4) (58) | Full Article (PDF)-5290K (270) | Full Article with Cover (PDF)-5640K (64) | Full Article (XML)-682K (37) | Audio-2663K (10) | Peer-Review Report-348K (51) | Answering Reviewers-173K (44) | Received: 03/29/2025 | Revised: 05/29/2025 | Accepted: 09/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1959) | Similar Articles (86) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Inflammatory biomarkers in the pathogenesis of pancreatic cancer: A literature review

Ayesha Aslam, Hafsa Hamid, Eman Fatima, Sumaira Pervaiz, Mehnaz Arif, Huda Irshad, Amina Shafqat, Sara Khan, Huma Khurshid, Saira Rafaqat

World J Clin Oncol 16(10):109385. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.109385

Abstract (81) | Core Tip (76) | Full Article (HTML) (565) | Figures (1-4) (49) | Full Article (PDF)-2843K (78) | Full Article with Cover (PDF)-3196K (168) | Full Article (XML)-282K (31) | Audio-686K (14) | Peer-Review Report-312K (45) | Answering Reviewers-768K (29) | Received: 05/08/2025 | Revised: 05/24/2025 | Accepted: 09/02/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (1681) | Similar Articles (525) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Catalase: The golden key to regulate oxidative stress in breast cancer

Jia-Wei Liu, Wen-Jia Chen, Yang-Zheng Lan, Jing Liu

World J Clin Oncol 16(10):110126. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.110126

Abstract (76) | Core Tip (57) | Full Article (HTML) (373) | Figures (1-3) (45) | Full Article (PDF)-15942K (90) | Full Article with Cover (PDF)-16295K (107) | Full Article (XML)-271K (42) | Audio-306K (14) | Peer-Review Report-226K (32) | Answering Reviewers-98K (31) | Received: 05/29/2025 | Revised: 06/25/2025 | Accepted: 09/17/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1644) | Similar Articles (306) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Global gene expression landscape of gallbladder cancer and advances in targeted therapeutic strategies

Sounetra Choudhury, Arunima Maiti, Arnab Bandopadhyay, Anusri Tripathi, Nilabja Sikdar

World J Clin Oncol 16(10):111028. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.111028

Abstract (70) | Core Tip (63) | Full Article (HTML) (288) | Figures (1-1) (50) | Tables (1-3) (50) | Full Article (PDF)-913K (72) | Full Article with Cover (PDF)-1263K (38) | Full Article (XML)-268K (33) | Audio-1311K (14) | Peer-Review Report-278K (53) | Answering Reviewers-69K (30) | Received: 06/20/2025 | Revised: 07/21/2025 | Accepted: 09/09/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1312) | Similar Articles (48) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Recent advances of circular RNAs in gastrointestinal cancer

Long-Fei Xie, Sheng-Yan Liu, Xiao-Wei Dang

World J Clin Oncol 16(10):111115. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.111115

Abstract (80) | Core Tip (70) | Full Article (HTML) (201) | Figures (1-1) (61) | Tables (1-1) (75) | Full Article (PDF)-901K (90) | Full Article with Cover (PDF)-1256K (47) | Full Article (XML)-227K (30) | Audio-198K (19) | Peer-Review Report-242K (26) | Answering Reviewers-48K (53) | Received: 06/23/2025 | Revised: 07/24/2025 | Accepted: 09/11/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1319) | Similar Articles (53) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Minireviews

Sidedness matters: Colon cancer outcomes in low-resource settings

Jaime González-Montero, Guillermo Valenzuela, Carlos I Rojas, Mauricio Burotto

World J Clin Oncol 16(10):108937. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.108937

Abstract (69) | Core Tip (73) | Full Article (HTML) (248) | Figures (1-1) (48) | Tables (1-1) (46) | Full Article (PDF)-643K (82) | Full Article with Cover (PDF)-996K (103) | Full Article (XML)-84K (31) | Audio-122K (8) | Peer-Review Report-224K (24) | Answering Reviewers-55K (32) | Received: 04/25/2025 | Revised: 05/27/2025 | Accepted: 09/08/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1392) | Similar Articles (193) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Neuro-tumor interactions: Multi-dimensional mechanisms of neurotransmitter regulation in tumor immune evasion and metabolic reprogramming

Ze-Kai Li, Jia-Lin Liao, Min-Rui Luo, Shu-Jie Fang, Wei-Zhen Huang, Dong-Yan Zhang

World J Clin Oncol 16(10):108954. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.108954

Abstract (66) | Core Tip (66) | Full Article (HTML) (476) | Tables (1-1) (51) | Full Article (PDF)-522K (121) | Full Article with Cover (PDF)-872K (173) | Full Article (XML)-208K (32) | Audio-388K (14) | Peer-Review Report-282K (29) | Answering Reviewers-93K (30) | Received: 04/26/2025 | Revised: 06/02/2025 | Accepted: 09/17/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1878) | Similar Articles (6) | Timeline of Article Publication (2) | Authors Evaluation (2) | Article Quality Tracking (0) | Cite |

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Radiotherapy treatment time delay evidence, part I: Update on cervical, anal, prostate, and head and neck cancers

Jose Antonio González Ferreira, Castalia Fernandez, Daniela Gonsalves, Imanol Paguey, Felipe Couñago

World J Clin Oncol 16(10):109247. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.109247

Abstract (86) | Core Tip (56) | Full Article (HTML) (535) | Tables (1-1) (65) | Full Article (PDF)-474K (164) | Full Article with Cover (PDF)-828K (74) | Full Article (XML)-149K (34) | Audio-1682K (32) | Peer-Review Report-227K (27) | Answering Reviewers-38K (34) | Received: 05/04/2025 | Revised: 06/04/2025 | Accepted: 09/05/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1836) | Similar Articles (109) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Subnational situation and public awareness of cancer control in China

Zhuo-Yu Li, Yuan Yang, Rui Wang, Xin-Zu Chen, SIGES Research Group

World J Clin Oncol 16(10):110246. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.110246

Abstract (109) | Core Tip (60) | Full Article (HTML) (210) | Figures (1-1) (41) | Full Article (PDF)-11122K (46) | Full Article with Cover (PDF)-11478K (34) | Full Article (XML)-73K (33) | Audio-776K (9) | Peer-Review Report-337K (29) | Answering Reviewers-62K (37) | Received: 06/02/2025 | Revised: 06/15/2025 | Accepted: 09/19/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (1964) | Similar Articles (0) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Expansion strategies for Vδ2 γδT cells in cancer immunotherapy: Activation, cytokines, and culture conditions

Natalia Lehman, Michal Zarobkiewicz

World J Clin Oncol 16(10):110466. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.110466

Abstract (67) | Core Tip (53) | Full Article (HTML) (320) | Figures (1-1) (51) | Tables (1-3) (54) | Full Article (PDF)-1440K (146) | Full Article with Cover (PDF)-1792K (60) | Full Article (XML)-210K (34) | Audio-198K (8) | Peer-Review Report-227K (55) | Answering Reviewers-81K (27) | Received: 06/06/2025 | Revised: 07/03/2025 | Accepted: 09/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1346) | Similar Articles (132) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Cancer rehabilitation in India: Current status, scope, and future perspectives

Raktim Swarnakar, Shiv Lal Yadav

World J Clin Oncol 16(10):110531. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.110531

Abstract (71) | Core Tip (70) | Full Article (HTML) (315) | Figures (1-1) (45) | Tables (1-1) (50) | Full Article (PDF)-3641K (130) | Full Article with Cover (PDF)-3992K (60) | Full Article (XML)-62K (35) | Audio-68K (25) | Peer-Review Report-242K (54) | Answering Reviewers-52K (27) | Received: 06/08/2025 | Revised: 06/24/2025 | Accepted: 09/17/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1491) | Similar Articles (285) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Retrospective Study

Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma

Lin Huang, Juan He

World J Clin Oncol 16(10):110047. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.110047

Abstract (66) | Core Tip (67) | Full Article (HTML) (217) | Figures (1-3) (42) | Tables (1-3) (47) | Full Article (PDF)-6816K (54) | Full Article with Cover (PDF)-7170K (71) | Full Article (XML)-109K (42) | Audio-302K (16) | Peer-Review Report-242K (24) | Answering Reviewers-434K (63) | Received: 06/05/2025 | Revised: 07/15/2025 | Accepted: 09/25/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2330) | Similar Articles (16) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Reader Comments (1) | Cite |

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Basic Study

Abnormal expression and potential clinical value of oncogenic Krüppel-like factor-5 in lung squamous cell carcinoma

Yang Shi, Wen-Li Sai, Jin-Liang Chen, Li-Wei Qiu, Min Yao, Jun Zhao, Deng-Fu Yao

World J Clin Oncol 16(10):111213. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.111213

Abstract (68) | Core Tip (71) | Full Article (HTML) (275) | Figures (1-5) (43) | Tables (1-3) (50) | Full Article (PDF)-20250K (72) | Full Article with Cover (PDF)-20604K (59) | Full Article (XML)-134K (27) | Audio-1683K (6) | Peer-Review Report-257K (24) | Answering Reviewers-879K (41) | Received: 06/25/2025 | Revised: 08/04/2025 | Accepted: 09/25/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1782) | Similar Articles (0) | Timeline of Article Publication (0) | Authors Evaluation (2) | Article Quality Tracking (0) | Cite |

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Overcoming chemoresistance in non-small cell lung cancer: Insights into the influence of inflammatory factors on treatment response

Jian-Qiang Xu, Zhen-Zhen Hu, Juan Feng, Xiu-Wen Tian, Nian Cao, Ya-Yun Liu, Yue Dai

World J Clin Oncol 16(10):112097. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.112097

Abstract (72) | Core Tip (44) | Full Article (HTML) (232) | Figures (1-5) (42) | Tables (1-2) (36) | Full Article (PDF)-11608K (87) | Full Article with Cover (PDF)-11962K (100) | Full Article (XML)-99K (43) | Audio-1061K (8) | Peer-Review Report-253K (41) | Answering Reviewers-65K (46) | Received: 07/17/2025 | Revised: 07/31/2025 | Accepted: 09/02/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (2254) | Similar Articles (56) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Evidence-Based Medicine

Surgeons’ opinions about enhanced recovery after surgery for retroperitoneal sarcoma: A survey

Luca Improta, Chiara Maura Ciniselli, Paolo Verderio, Sandro Pasquali, Marco Fiore, Sergio Valeri

World J Clin Oncol 16(10):108419. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.108419

Abstract (54) | Core Tip (61) | Full Article (HTML) (241) | Figures (1-4) (43) | Tables (1-2) (50) | Full Article (PDF)-4154K (147) | Full Article with Cover (PDF)-4507K (35) | Full Article (XML)-149K (31) | Audio-990K (13) | Peer-Review Report-259K (33) | Answering Reviewers-126K (69) | Received: 04/13/2025 | Revised: 06/22/2025 | Accepted: 09/29/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1372) | Similar Articles (43) | Timeline of Article Publication (1) | Article Quality Tracking (0) | Cite |

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Meta-Analysis

Neoadjuvant immunotherapy in resectable hepatocellular carcinoma: A meta-analysis of the current evidence

Ottavia Cicerone, Barbara Oliviero, Stefania Mantovani, Laura Maiocchi, Valentina Ravetta, Francesca Berton, Salvatore Corallo, Alessandro Vanoli, Marcello Maestri

World J Clin Oncol 16(10):110511. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.110511

Abstract (82) | Core Tip (75) | Full Article (HTML) (256) | Figures (1-5) (50) | Tables (1-5) (50) | Full Article (PDF)-7814K (170) | Full Article with Cover (PDF)-8168K (79) | Full Article (XML)-122K (31) | Audio-232K (11) | Peer-Review Report-227K (57) | Answering Reviewers-109K (55) | Supplementary Material-268K (53) | Received: 06/07/2025 | Revised: 06/25/2025 | Accepted: 09/11/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1811) | Similar Articles (1880) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Ropeginterferon alfa-2b vs standard therapy in polycythemia vera: A meta-analysis of efficacy and safety outcomes

Leo Tom, Shinjit Mani, Akash Rawat, Mina Nan, Shruti Manoj Mundada, Basel Al Khatib, Aparna Gopinath, Osama Taj, Namitha Salahuddin, Farzana Shaju, Syeda Parsa, Mahmud Abdurrahman, Ashesh Das, Mirza Muhammad Hadeed Khawar, Ali Sher

World J Clin Oncol 16(10):112392. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.112392

Abstract (87) | Core Tip (99) | Full Article (HTML) (695) | Figures (1-3) (64) | Tables (1-2) (52) | Full Article (PDF)-1902K (147) | Full Article with Cover (PDF)-2252K (39) | Full Article (XML)-117K (32) | Audio-691K (15) | Peer-Review Report-253K (50) | Answering Reviewers-89K (50) | Supplementary Material-72K (52) | Received: 07/25/2025 | Revised: 08/04/2025 | Accepted: 09/26/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1982) | Similar Articles (6) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Case Report

Robotic approach for lymphadenectomy of internal mammary lymph nodes in breast cancer: Five case reports

Alessandro Pardolesi, Michele Ferrari, Giovanni Leuzzi, Alessia Stanzi, Matteo Calderoni, Clarissa Uslenghi, Marco Scarci, Federico Raveglia, Ugo Cioffi, Piergiorgio Solli

World J Clin Oncol 16(10):108876. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.108876

Abstract (82) | Core Tip (67) | Full Article (HTML) (259) | Figures (1-4) (72) | Tables (1-1) (48) | Full Article (PDF)-3999K (66) | Full Article with Cover (PDF)-4354K (36) | Full Article (XML)-65K (28) | Audio-552K (11) | Peer-Review Report-202K (33) | Answering Reviewers-148K (39) | Received: 04/24/2025 | Revised: 05/30/2025 | Accepted: 09/02/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2055) | Similar Articles (4780) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Letter to the Editor

Advancing early detection of gastric cancer through serum cytokine profiling

Duygu Kirkik, Yesim Uygun Kızmaz, Sevgi Kalkanli Tas

World J Clin Oncol 16(10):109736. Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.109736

Abstract (69) | Core Tip (57) | Full Article (HTML) (202) | Full Article (PDF)-368K (35) | Full Article with Cover (PDF)-721K (46) | Full Article (XML)-41K (32) | Audio-845K (13) | Peer-Review Report-258K (37) | Answering Reviewers-135K (25) | Received: 05/19/2025 | Revised: 06/28/2025 | Accepted: 09/08/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1248) | Similar Articles (693) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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