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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Oct 24, 2025; 16(10): 107877
Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.107877
Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.107877
Gut microbiome and nutritional strategies in gastrointestinal cancers: Clinical implications and therapeutic perspectives
Vilma Pacheco-Barcia, Sara Custodio-Cabello, Magda Palka-Kotlowska, Luis Cabezon-Gutierrez, Department of Medical Oncology, Hospital Universitario de Torrejon, Madrid 28850, Spain
Vilma Pacheco-Barcia, Faculty of Medicine, Francisco de Vitoria University, Madrid 28223, Spain
Axel Mariño-Mendez, Paula Jimenez-Fonseca, Department of Medical Oncology, Hospital Universitario Central de Asturias, Oviedo 33011, Spain
Enrique Hernandez-Jimenez, Department of Research and Development, Loop Diagnostics, Barcelona 08005, Catalonia, Spain
Andrés Jesús Muñoz Martín, Department of Medical Oncology, Hospital General Universitario Gregorio Marañón, Universidad Complutense Madrid, Madrid 28007, Spain
Ivan Gonzalez-Diaz, Department of Gynecology, Hospital Universitario Severo Ochoa, Leganes 28914, Madrid, Spain
Author contributions: Pacheco-Barcia V conceptualized and analyzed the literature, prepared the data to be presented and wrote the review; Mariño-Mendez A and Hernandez-Jimenez E made critical revisions; Jimenez-Fonseca P and Muñoz Martín AJ conducted the literature review; Custodio-Cabello S, Palka-Kotlowska M, and Gonzalez-Diaz I interpreted data; Cabezon-Gutierrez L evaluated the data obtained, wrote review and collaborated in draft of the review; and all authors prepared the draft and approved the submitted version.
Conflict-of-interest statement: Dr. Pacheco Barcia reports grants from FSEOM and MERCK, from Nutricia, from Servier, from LEO Pharma, from PFizer, from Amgen, outside the submitted work.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vilma Pacheco-Barcia, MD, PhD, Professor, Department of Medical Oncology, Hospital Universitario de Torrejon, C/Mateo Inurria S/N, Madrid 28850, Spain.
Received: April 2, 2025
Revised: May 29, 2025
Accepted: September 22, 2025
Published online: October 24, 2025
Processing time: 208 Days and 8.9 Hours
Revised: May 29, 2025
Accepted: September 22, 2025
Published online: October 24, 2025
Processing time: 208 Days and 8.9 Hours
Core Tip
Core Tip: Gastrointestinal malignancies, more specifically pancreatobiliary and gastroesophageal cancers, harbor a bad prognosis mainly because tumors are frequently diagnosed in an advanced stage. Most of the tumors of the digestive tract associate anorexia-cachexia syndrome as well as malnutrition. Inflammation is a key feature of neoplasic proliferation and gut microbiome may have an interplay in inflammation and outcomes of these patients. In this article, we want to address this association and the impact of nutritional strategies in patients with gastrointestinal malignancies.