Liu JW, Chen WJ, Lan YZ, Liu J. Catalase: The golden key to regulate oxidative stress in breast cancer. World J Clin Oncol 2025; 16(10): 110126 [DOI: 10.5306/wjco.v16.i10.110126]
Corresponding Author of This Article
Jing Liu, MD, PhD, Associate Professor, The Breast Center, Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou 515041, Guangdong Province, China. jliu12@stu.edu.cn
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Oncology
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Review
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 24, 2025 (publication date) through Oct 27, 2025
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World Journal of Clinical Oncology
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2218-4333
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Liu JW, Chen WJ, Lan YZ, Liu J. Catalase: The golden key to regulate oxidative stress in breast cancer. World J Clin Oncol 2025; 16(10): 110126 [DOI: 10.5306/wjco.v16.i10.110126]
World J Clin Oncol. Oct 24, 2025; 16(10): 110126 Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.110126
Catalase: The golden key to regulate oxidative stress in breast cancer
Jia-Wei Liu, Wen-Jia Chen, Yang-Zheng Lan, Jing Liu
Jia-Wei Liu, Wen-Jia Chen, Yang-Zheng Lan, Jing Liu, The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China
Co-first authors: Jia-Wei Liu and Wen-Jia Chen.
Author contributions: Liu J designed this study; Liu JW and Chen WJ searched the publication, prepared the draft of the manuscript as the co-first authors of the paper; Liu JW, Chen WJ, and Lan YZ prepared the figures; Liu J revised the manuscript critically; Liu JW, Chen WJ, Lan YZ, and Liu J interpreted the results, constructed the structure of the review, and prepared the tables; and all authors have read and approve the final manuscript.
Supported by National Natural Science Foundation of China, No. 82273457; Natural Science Foundation of Guangdong Province, No. 2023A1515012762; and Science and Technology Special Project of Guangdong Province, No. 210715216902829.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Liu, MD, PhD, Associate Professor, The Breast Center, Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou 515041, Guangdong Province, China. jliu12@stu.edu.cn
Received: May 30, 2025 Revised: June 25, 2025 Accepted: September 17, 2025 Published online: October 24, 2025 Processing time: 148 Days and 0.9 Hours
Abstract
Catalase (CAT) is a kind of tetrameric protein in the human body, play as a key regulator for controlling oxidative stress. The main function of CAT is to regulate the concentration of hydrogen peroxide (H2O2) by catalyzing the decomposition of H2O2. At present, it is reported that CAT is also involved in regulating the oxidative stress in tumor cells, and its expression level is significantly related to the development of breast cancer (BC). In addition, CAT with different expression patterns, was related in the proliferation, invasion, treatment and prognosis of BC cells. Meanwhile, BC is a common and well-known cancer among women worldwide, and its incidence has been increasing in recent years. Therefore, in-depth study of CAT in the pathogenesis and progression of BC is of great significance for the future treatment and diagnosis. The present review summarized the effects of oxidative stress on cancer cells, and emphasized the key role of CAT in the development of BC, which provides a key clue for promoting research on BC and selecting therapeutic targets.
Core Tip: Catalase (CAT) plays a critical role in breast cancer (BC) by regulating oxidative stress. Its expression is regulated by hormone receptors and epigenetics and is closely related to the metastatic site and prognosis of BC. Therapeutic strategies targeting CAT provides a potential promising new avenue for advancing BC treatment.
