Recent advances of circular RNAs in gastrointestinal cancer

Table 1 Circular RNAs in gastrointestinal cancer

Type of cancer	circRNAs	Expression	miRNAs, RBPs, peptides, pathways	Function	Ref.
Esophageal cancer	circTMEM45A	Up	U2AF2, NLRP3/caspase 1/IL-1β	Promotes malignant progression and inflammatory progression	[52]
Esophageal cancer	circPRKCA	Up	YBX1/CSF2	Promotes migration, invasion, and angiogenesis	[53]
Esophageal cancer	circNF1	Up	ANXA1, JAK/STAT3	Increases proliferation, metastasis, and tumor evasion	[54]
Esophageal cancer	circMMP11	Up	miR-671-5p	Increases proliferation, migration, and invasion	[55]
Esophageal cancer	hsa_circ_0087104	Down	miR-542-3p/PIK3R1	Inhibits metastasis	[56]
Esophageal cancer	hsa_circ_0001165	Up	EIF4A3, miR-381-3p/TNS3	Promotes proliferation, invasion, and migration	[57]
Esophageal cancer	circJPH1	Up	NF-κB/HERC5, XRCC6	Promotes proliferation, invasion, and migration	[58]
Esophageal cancer	hsa_circ_0001615	Down	miR-142-5p/β-catenin	Inhibits proliferation, migration, and invasion, promotes apoptosis	[59]
Esophageal cancer	circPDE5A	Down	PI3K/AKT	Inhibits proliferation and metastasis	[60]
Esophageal cancer	circSSPO	Up	miR-6820-5p/KLK8/PKD1	Promotes tumorigenesis and metastasis	[61]
Esophageal cancer	circUBE4B	Up	MAPK/ERK	Promotes proliferation	[62]
Esophageal cancer	circ-TNRC6B	Down	miR-452-5p/DAG1	Inhibits proliferation and invasion	[63]
Gastric cancer	circSCAF8	Up	miR-1293/TIMP1	Promotes proliferation, invasion, and migration	[64]
Gastric cancer	circPFKP	Down	miR-346/CAMD3	Inhibits proliferation, invasion, and migration	[65]
Gastric cancer	hsa_circ_0079226	Up	miR-155-5p/FOXK1/AKT	Promotes proliferation, invasion, and migration	[66]
Gastric cancer	hsa_circ_0008126	Down	EIF4A3, APC/β-Catenin	Inhibits progression and metastasis	[67]
Gastric cancer	circATP8A1	Up	miR-1-3p/STAT6	Promotes proliferation and invasion	[68]
Gastric cancer	circBIRC6	Up	miR-488/GRIN2D	Promotes malignant progression	[69]
Gastric cancer	circPAK2	Up	IGF2BPs/VEGFA	Promotes lymph node metastasis	[70]
Gastric cancer	hsa_circ_0136666	Up	miR-375/PRKDC, PD-L1	Promotes progression and tumor immune escape	[71]
Gastric cancer	circSTAU2	Down	miR-589/CAPZA1	Inhibits proliferation, invasion, and migration	[72]
Gastric cancer	circGAPVD1	Down	miR-4424/STK4, GAPVD1-137aa	Inhibits tumor progression, encodes GAPVD1-137aa	[73]
Gastric cancer	circZNF131	Down	ZNF131-354aa	Encodes ZNF131-354aa, inhibits tumor progression	[24]
Gastric cancer	hsa_circ_0002301	Down	HECTD1-463aa	Encodes HECTD1-463aa, inhibits ferroptosis	[74]
Gastric cancer	circ0003692	Down	FNDC3B-267aa	Encodes FNDC3B-267aa, inhibits metastasis	[75]
Gastric cancer	circPGD	Up	miR-16-5p/ABL2, PGD-219aa	Promotes tumor progression, encodes PGD-219aa	[25]
Liver cancer	circFADS1	Up	EIF4A3, Wnt/β-Catenin	Promotes proliferation and inhibits apoptosis	[76]
Liver cancer	circDCUN1D4	Down	miR-590-5p/ TIMP3	Suppresses proliferation, migration, and invasion	[77]
Liver cancer	circTTC13	Up	miR-513a-5p/SLC7A11	Promotes sorafenib resistance	[78]
Liver cancer	circPIAS1	Up	miR-455-3p/NUPR1/FTH1	Promotes tumor progression	[79]
Liver cancer	circPTPN12	Down	ESRP1, PDLIM2/ NF-κB	Suppresses proliferation, poor prognosis	[80]
Liver cancer	hsa_circ_0044539	Up	miR-29a-3p/VEGFA	Promotes lymph node metastasis	[81]
Liver cancer	circPHKB	Up	miR-1234-3p/CYP2W1	Promotes sorafenib resistance	[82]
Liver cancer	circUSP10	Up	miR-211-5p/TCF12/EMT	Promotes tumor progression	[83]
Liver cancer	circMRCKα	Up	circMRCKα-227aa	Encodes circMRCKα-227aa, promotes glycolysis and progression	[84]
Liver cancer	circSTX6	Up	HNRNPD/ATF3, circSTX6-144aa	Encodes circSTX6-144aa, promotes tumor progression	[85]
Liver cancer	circMAP3K4	Up	circMAP3K4-455aa	Encodes circMAP3K4-455aa, inhibits apoptosis	[28]
Pancreatic cancer	circPHF14	Up	EIF4E, Wnt/β-catenin	Promotes growth and metastasis	[86]
Pancreatic cancer	circCEACAM5	Up	METTL3, DKC1	Promotes proliferation, invasion, and migration, inhibits apoptosis	[87]
Pancreatic cancer	hsa_circ_0004781	Up	miR-9-5p/KLF5, miR-338-3p/ADAM17	Promotes proliferation and migration	[88]
Pancreatic cancer	circCGNL1	Down	NUDT4/HDAC4/RUNX2/GAMT	Inhibits proliferation, promoting apoptosis	[89]
Pancreatic cancer	circRPS29	Up	miR-770-5p/TRIM29, MEK/ERK	Promotes gemcitabine resistance	[90]
Pancreatic cancer	circDUSP22	Down	miR-1178-3p/BNIP3	Restrains cancer development	[91]
Pancreatic cancer	circSTK39	Up	miR-140-3p/TRAM2	Promotes proliferation and migration	[92]
Colorectal cancer	hsa_circ_0009022	Down	miR-576-5p, FMRP	Inhibits proliferation and migration	[93]
Colorectal cancer	circMVP	Up	METTL3/CTNNB1/β-catenin	Increases proliferation, invasion, and tumorigenesis	[94]
Colorectal cancer	circEIF3I	Up	miR-328-3p/NCAPH	Promotes metastasis	[95]
Colorectal cancer	circMYBL2	Down	p185 protein	Suppresses cancer progression, encodes p185 protein	[96]
Colorectal cancer	hsa_circ_0000467	Up	eIF4A3/c-Myc	Promotes growth and metastasis	[97]
Colorectal cancer	hsa_circ_0017065	Up	miR-3174/RBFOX2	Promotes proliferation and metastasis	[98]
Colorectal cancer	circSTIL	Up	miR-431/SLC7A11	Inhibits ferroptosis	[99]
Colorectal cancer	circCAPRIN1	Up	STAT2/ACC1	Promotes proliferation, migration, and EMT	[100]
Colorectal cancer	circINSIG1	Up	circINSIG1-121aa	Encodes circINSIG1-121aa, promotes proliferation and metastasis	[101]
Colorectal cancer	circATG4B	Up	circATG4B-222aa	Encodes circATG4B-222aa, promotes autophagy and oxaliplatin resistance	[32]

circRNA: Circular RNAs; miRNA: MicroRNAs; aa: Amino acid; EMT: Epithelial-mesenchymal transition.