Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma

Figure 1 A bar graph of the correlation between human epidermal growth factor receptor 2 expression and tumor grade in upper tract urothelial carcinoma patients. HER2: Human epidermal growth factor receptor 2.

Figure 2 The representative immunohistochemical staining patterns of four different intensity grades of human epidermal growth factor receptor 2. A: No staining observed or < 10% of invasive tumor cells showed incomplete and faint membrane staining were scored 0; B: ≥ 10% of invasive tumor cells demonstrated incomplete and faint membrane staining were scored 1+; C: Either ≥ 10% of invasive tumor cells showed weak-to-moderate intensity complete circumferential membrane staining or < 10% of invasive tumor cells exhibited complete circumferential membrane staining were scored 2+; D: ≥ 10% of invasive tumor cells showed strong intensity complete circumferential membrane staining were scored 3+; Original magnification, × 200.

Figure 3 The representative immunohistochemical staining patterns of CK20 and CK5/6. A: CK20; B: CK5/6; Original magnification, × 200.