Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma
Lin Huang, Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Juan He, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Huang L performed the conceptualization, methodology, formal analysis, software, data curation, writing-original draft preparation, writing- reviewing and editing; He J performed the conceptualization, supervision, resources, writing- reviewing and editing. All authors have read and approve the final manuscript.
Supported by Scientific Research Project of Health Commission of Guangxi Zhuang Autonomous Region, No. Z-A20240546; Undergraduate Education and Teaching Reform Project of Guangxi Medical University, No. 2025XJGYC38; and Key Textbook Construction Project of Guangxi Medical University, No. Gxmuzdjc2417.
Institutional review board statement: The study protocol was approved by the Institutional Ethics Committee of The First Affiliated Hospital of Guangxi Medical University, approval No. 2025-E0353.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Juan He, Professor, Researcher, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
hejuan@stu.gxmu.edu.cn
Received: June 7, 2025
Revised: July 15, 2025
Accepted: September 25, 2025
Published online: October 24, 2025
Processing time: 140 Days and 19.6 Hours
