Huang L, He J. Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma. World J Clin Oncol 2025; 16(10): 110047 [PMID: 41178915 DOI: 10.5306/wjco.v16.i10.110047]
Corresponding Author of This Article
Juan He, Professor, Researcher, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. hejuan@stu.gxmu.edu.cn
Research Domain of This Article
Urology & Nephrology
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Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 24, 2025 (publication date) through Feb 23, 2026
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Publication Name
World Journal of Clinical Oncology
ISSN
2218-4333
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Huang L, He J. Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma. World J Clin Oncol 2025; 16(10): 110047 [PMID: 41178915 DOI: 10.5306/wjco.v16.i10.110047]
World J Clin Oncol. Oct 24, 2025; 16(10): 110047 Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.110047
Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma
Lin Huang, Juan He
Lin Huang, Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Juan He, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Huang L performed the conceptualization, methodology, formal analysis, software, data curation, writing-original draft preparation, writing- reviewing and editing; He J performed the conceptualization, supervision, resources, writing- reviewing and editing. All authors have read and approve the final manuscript.
Supported by Scientific Research Project of Health Commission of Guangxi Zhuang Autonomous Region, No. Z-A20240546; Undergraduate Education and Teaching Reform Project of Guangxi Medical University, No. 2025XJGYC38; and Key Textbook Construction Project of Guangxi Medical University, No. Gxmuzdjc2417.
Institutional review board statement: The study protocol was approved by the Institutional Ethics Committee of The First Affiliated Hospital of Guangxi Medical University, approval No. 2025-E0353.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Juan He, Professor, Researcher, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. hejuan@stu.gxmu.edu.cn
Received: June 7, 2025 Revised: July 15, 2025 Accepted: September 25, 2025 Published online: October 24, 2025 Processing time: 140 Days and 19.6 Hours
Core Tip
Core Tip: This is a retrospective single-center observational study to evaluate human epidermal growth factor receptor 2 (HER2) expression patterns by immunohistochemistry in 145 upper tract urothelial carcinoma (UTUC) specimens and assessed its correlation with tumor grade, stage, molecular subtype, and other clinicopathological parameters. HER2 overexpression in UTUC is strongly linked to tumor dedifferentiation (high grade), while other variables including sex, anatomical tumor location, pathological T stage, Ki-67 proliferation index, nodal metastasis status, lymphovascular invasion, and tumor laterality all failed to demonstrate statistically meaningful correlations. This distinct pattern suggests HER2 may play a unique biological role in UTUC compared to other epithelial malignancies.
