From infection to invasion: The role of deleted in malignant brain tumors 1 in Helicobacter pylori-driven gastric cancer

doi:10.5306/wjco.v16.i10.108377

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 10

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (1125)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-1) series.

Item

Count

PDF

104

HTML

124

Figures (1-1)

Tables (1-1)

Sum=278

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

252

Download

305

Sum=557

Publishing Process of This Article

Item

Count

Browse

Download

170

Sum=218

Oct 24, 2025 (publication date) through Feb 16, 2026

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Clinical Oncology

ISSN

2218-4333

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Editorial

World J Clin Oncol. Oct 24, 2025; 16(10): 108377
Published online Oct 24, 2025. doi: 10.5306/wjco.v16.i10.108377

From infection to invasion: The role of deleted in malignant brain tumors 1 in Helicobacter pylori-driven gastric cancer

Ionut Negoi

Ionut Negoi, Department of General Surgery, Carol Davila University of Medicine and Pharmacy Bucharest, Clinical Emergency Hospital of Bucharest, Bucharest 014461, Romania

Author contributions: Negoi I contributed to this study, designed the overall concept and outline of the manuscript, contributed to the discussion and design of the manuscript, contributed to the writing, and edited the manuscript, and review of the literature.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Corresponding author: Ionut Negoi, MD, PhD, Associate Professor, Department of General Surgery, Carol Davila University of Medicine and Pharmacy Bucharest, Clinical Emergency Hospital of Bucharest, No. 8 Floreasca Street, Sector 1, Bucharest 014461, Romania. negoiionut@gmail.com

Received: April 14, 2025
Revised: May 24, 2025
Accepted: September 2, 2025
Published online: October 24, 2025
Processing time: 195 Days and 6.9 Hours

Core Tip

Core Tip: Gastric cancer (GC) remains a major global health issue closely linked to Helicobacter pylori (H. pylori) infection, which induces chronic inflammation, oxidative DNA damage, and disrupts cell cycle regulation. Cytotoxin-associated gene A plays a significant role in carcinogenesis. Deleted in malignant brain tumors 1 (DMBT1), a potential tumor suppressor, shows variable expression in GC, often being downregulated in well-differentiated adenocarcinomas and upregulated in other subtypes. DMBT1 interacts directly with H. pylori to modulate the immune response. Preserved DMBT1 expression may protect against gastric carcinogenesis, whereas its downregulation may facilitate tumor progression. Understanding the DMBT1-H. pylori interaction could help identify new therapeutic strategies for the prevention and treatment of GC.