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Contents Volume 31 Issue 48 December 28, 2025

Editorial

Harnessing early enzymatic biomarkers and cytokines for risk prediction in post-endoscopic retrograde cholangiopancreatography pancreatitis

Abdellatif Bouayad

World J Gastroenterol 31(48):114786. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.114786

Abstract (83) | Core Tip (53) | Full Article (HTML) (267) | Figures (1-1) (40) | Tables (1-1) (40) | Full Article (PDF)-587K (67) | Full Article with Cover (PDF)-861K (27) | Full Article (XML)-93K (32) | Audio-480K (3) | Peer-Review Report-170K (25) | Answering Reviewers-274K (28) | Received: 09/27/2025 | Revised: 10/28/2025 | Accepted: 11/12/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1612) | Similar Articles (31) | Timeline of Article Publication (2) | Authors Evaluation (5) | Article Quality Tracking (0) | Cite |

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Review

Relationship between Epstein-Barr virus and inflammatory bowel disease

Su-Ying Li, Jia Jia, Lu-Zhou Xu, Kai Zheng

World J Gastroenterol 31(48):111187. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.111187

Abstract (77) | Core Tip (54) | Full Article (HTML) (506) | Figures (1-2) (47) | Tables (1-1) (42) | Full Article (PDF)-3393K (65) | Full Article with Cover (PDF)-3664K (25) | Full Article (XML)-397K (21) | Audio-1563K (3) | Peer-Review Report-285K (23) | Answering Reviewers-498K (24) | Received: 07/08/2025 | Revised: 08/17/2025 | Accepted: 11/11/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1873) | Similar Articles (696) | Timeline of Article Publication (3) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways

Siva Sundara Kumar Durairajan, Abhay Kumar Singh, Shahitha M Sulaiman, Supriti Patnaik, Senthilkumar Krishnamoorthi, Ashok Iyaswamy, Balachandar Vellingiri, Chuan-Bin Yang, Leonard L Williams

World J Gastroenterol 31(48):111301. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.111301

Abstract (65) | Core Tip (56) | Full Article (HTML) (502) | Figures (1-4) (49) | Tables (1-3) (46) | Full Article (PDF)-4573K (83) | Full Article with Cover (PDF)-4847K (26) | Full Article (XML)-386K (32) | Audio-4456K (3) | Peer-Review Report-253K (27) | Answering Reviewers-163K (30) | Received: 06/27/2025 | Revised: 09/17/2025 | Accepted: 11/10/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1546) | Similar Articles (687) | Timeline of Article Publication (0) | Article Quality Tracking (1) | Cite |

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Mitochondrial dysfunction as a bridge to pathology in acute pancreatitis: From molecular insights to novel therapeutic strategies

Guo-Qiang Xu, Zhen-Huan Wang, Yue Xu, Chuan-Chao Xia

World J Gastroenterol 31(48):113840. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.113840

Abstract (71) | Core Tip (54) | Full Article (HTML) (322) | Figures (1-2) (48) | Tables (1-1) (47) | Full Article (PDF)-1170K (59) | Full Article with Cover (PDF)-1444K (29) | Full Article (XML)-242K (23) | Audio-240K (3) | Peer-Review Report-307K (22) | Answering Reviewers-147K (23) | Received: 09/04/2025 | Revised: 10/28/2025 | Accepted: 11/14/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1305) | Similar Articles (279) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Retrospective Cohort Study

Artificial intelligence-assisted diagnosis of rectal neuroendocrine tumors during white-light endoscopy

Ke Liu, Zhen-Yu Wang, Li-Zhi Yi, Feng Li, Shun-Hui He, Xi-Gang Zhang, Chun-Xiao Lai, Zhi-Jian Li, Lin Qiu, Rui-Ya Zhang, Wen Wu, Yu Lin, Hui Yang, Gui-Ming Liu, Quan-Sheng Guan, Zhi-Fang Zhao, Li-Ming Cheng, Jie Dai, Yang Bai, Fang Xie, Meng-Nan Zhang, Su-Zuan Chen, Xian-Fei Zhong

World J Gastroenterol 31(48):112683. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.112683

Abstract (79) | Core Tip (67) | Full Article (HTML) (344) | Figures (1-4) (47) | Tables (1-7) (42) | Full Article (PDF)-10536K (65) | Full Article with Cover (PDF)-10809K (31) | Full Article (XML)-113K (33) | Audio-546K (7) | Peer-Review Report-291K (25) | Answering Reviewers-84K (33) | Supplementary Material-104K (28) | Received: 08/02/2025 | Revised: 09/17/2025 | Accepted: 11/12/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2914) | Similar Articles (475) | Timeline of Article Publication (1) | Article Quality Tracking (1) | Cite |

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AADN score: Predicting response to transarterial chemoembolization, sintilimab and lenvatinib in patients with hepatocellular carcinoma

Hong-Song Chen, Dong-Bo Chen, Yuan-Ping Zhou, Xu Cong, Ran Fei, Shao-Ping She, Shao-Wei Mu, Wan-Ying Qin, Li-Ying Ren, Min-Jun Liao, Xue Zhang

World J Gastroenterol 31(48):113856. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.113856

Abstract (56) | Core Tip (60) | Full Article (HTML) (404) | Figures (1-4) (42) | Tables (1-3) (42) | Full Article (PDF)-2634K (56) | Full Article with Cover (PDF)-2909K (75) | Full Article (XML)-156K (23) | Audio-3625K (3) | Peer-Review Report-241K (22) | Answering Reviewers-335K (26) | Received: 09/08/2025 | Revised: 10/11/2025 | Accepted: 11/10/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (2734) | Similar Articles (1925) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Retrospective Study

Serum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunction-associated steatotic liver disease

Yang Wang, Guang-Hui Ma, Ming-Yue Qu, Qi-Shui Xu, Hai-Xia Huang

World J Gastroenterol 31(48):112972. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.112972

Abstract (57) | Core Tip (57) | Full Article (HTML) (348) | Figures (1-4) (43) | Tables (1-2) (43) | Full Article (PDF)-2424K (72) | Full Article with Cover (PDF)-2699K (122) | Full Article (XML)-99K (27) | Audio-715K (5) | Peer-Review Report-236K (24) | Answering Reviewers-129K (34) | Received: 08/11/2025 | Revised: 09/16/2025 | Accepted: 11/12/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1926) | Similar Articles (108) | Timeline of Article Publication (0) | Authors Evaluation (2) | Article Quality Tracking (0) | Cite |

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Observational Study

Clinical, pathological characteristics and long-term outcomes of hepatitis B virus related cirrhosis in pediatric observational study

Bo-Kang Zhao, Yan Li, Yi-Yun Jiang, Mei-Ling Li, Yue Jiang, Li Zhu, Chao-Nan Guo, Shu-Hong Liu, Lin Chen, Li-Na Jiang, Jun-Qi Niu, Jing-Min Zhao

World J Gastroenterol 31(48):114049. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.114049

Abstract (72) | Core Tip (88) | Full Article (HTML) (268) | Figures (1-3) (45) | Tables (1-6) (40) | Full Article (PDF)-5271K (56) | Full Article with Cover (PDF)-5546K (96) | Full Article (XML)-137K (32) | Audio-1301K (10) | Peer-Review Report-296K (26) | Answering Reviewers-252K (29) | Received: 09/10/2025 | Revised: 10/12/2025 | Accepted: 11/10/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (2800) | Similar Articles (507) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Clinical outcomes and drug sustainability after non-medical switch from ustekinumab originator to biosimilars in inflammatory bowel disease

Justin Kritzinger, Ivanna Candel, Gynter Kotrri, Huzaifa Nadeem, Waqqas Afif, Alain Bitton, Gary Wild, Talat Bessissow, Peter Laszlo Lakatos

World J Gastroenterol 31(48):114355. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.114355

Abstract (84) | Core Tip (55) | Full Article (HTML) (550) | Figures (1-2) (44) | Tables (1-2) (39) | Full Article (PDF)-605K (76) | Full Article with Cover (PDF)-878K (102) | Full Article (XML)-118K (33) | Audio-362K (9) | Peer-Review Report-244K (24) | Answering Reviewers-253K (23) | Received: 09/16/2025 | Revised: 10/15/2025 | Accepted: 11/12/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (2280) | Similar Articles (667) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Basic Study

Sphinganine inhibits macrophage polarization and protects against sepsis-induced intestinal injury

Yi-Fan Chen, Ze-Tian Wang, Jian Zhao, Jian-Guo Tang, Bai-Yin Zhang

World J Gastroenterol 31(48):112004. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.112004

Abstract (69) | Core Tip (55) | Full Article (HTML) (297) | Figures (1-4) (50) | Full Article (PDF)-27808K (60) | Full Article with Cover (PDF)-28083K (31) | Full Article (XML)-74K (21) | Audio-1045K (7) | Peer-Review Report-208K (30) | Answering Reviewers-320K (22) | Supplementary Material-84K (27) | Received: 07/22/2025 | Revised: 09/20/2025 | Accepted: 11/10/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1978) | Similar Articles (107) | Timeline of Article Publication (3) | Article Quality Tracking (0) | Cite |

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Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients

Natalya B Zakharzhevskaya, Svetlana I Erdes, Elena A Belousova, Ivan S Samolygo, Marina A Manina, Polina V Kondrashova, Ekaterina Y Lomakina, Dmitry A Kardonsky, Elizaveta A Vorobyeva, Olga Y Shagaleeva, Artemiy A Silantyev, Victoriia D Kazakova, Daria A Kashatnikova, Tatiana N Kalachnuk, Irina V Kolesnikova, Andrey V Chaplin, Maria I Markelova, Tatiana V Grigoryeva, Evgenii I Olekhnovich, Vladimir A Veselovsky, Maxim D Morozov, Polina Y Zoruk, Daria I Boldyreva, Anna A Vanyushkina, Boris A Efimov

World J Gastroenterol 31(48):112653. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.112653

Abstract (73) | Core Tip (80) | Full Article (HTML) (529) | Figures (1-10) (46) | Tables (1-1) (43) | Full Article (PDF)-17901K (65) | Full Article with Cover (PDF)-18172K (30) | Full Article (XML)-228K (39) | Audio-4859K (13) | Peer-Review Report-227K (33) | Answering Reviewers-709K (45) | Supplementary Material-2424K (30) | Received: 08/01/2025 | Revised: 09/09/2025 | Accepted: 11/11/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (2394) | Similar Articles (663) | Timeline of Article Publication (4) | Authors Evaluation (10) | Article Quality Tracking (0) | Cite |

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Systematic Reviews

Exploring exercise modalities and their impact on inflammatory bowel disease: A systematic review of rodent colitis models

Shao-Peng Sun, Yu-Qing Mao, Yi-Hong Fan, Bin Lv

World J Gastroenterol 31(48):113243. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.113243

Abstract (60) | Core Tip (52) | Full Article (HTML) (421) | Figures (1-1) (46) | Tables (1-3) (42) | Full Article (PDF)-615K (50) | Full Article with Cover (PDF)-889K (35) | Full Article (XML)-181K (30) | Audio-1605K (11) | Peer-Review Report-178K (21) | Answering Reviewers-424K (30) | Supplementary Material-105K (30) | Received: 08/19/2025 | Revised: 09/28/2025 | Accepted: 11/14/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (1614) | Similar Articles (723) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Letter to the Editor

Gut microbiota: An overlooked target in dyslipidemia management

Ammara Abdul Majeed, Amna Subhan Butt

World J Gastroenterol 31(48):113178. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.113178

Abstract (67) | Core Tip (61) | Full Article (HTML) (487) | Figures (1-1) (42) | Full Article (PDF)-636K (59) | Full Article with Cover (PDF)-910K (82) | Full Article (XML)-78K (32) | Audio-376K (8) | Peer-Review Report-271K (24) | Answering Reviewers-118K (26) | Received: 08/17/2025 | Revised: 10/01/2025 | Accepted: 11/03/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (1403) | Similar Articles (19) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Capecitabine maintenance after radiofrequency ablation: A preventive strategy for lung oligometastases from colorectal cancer

Francesco Giangregorio

World J Gastroenterol 31(48):113550. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.113550

Abstract (62) | Core Tip (54) | Full Article (HTML) (293) | Tables (1-1) (46) | Full Article (PDF)-437K (42) | Full Article with Cover (PDF)-711K (26) | Full Article (XML)-94K (30) | Audio-1384K (4) | Peer-Review Report-221K (21) | Answering Reviewers-125K (27) | Received: 08/27/2025 | Revised: 10/11/2025 | Accepted: 11/06/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1114) | Similar Articles (1254) | Timeline of Article Publication (2) | Article Quality Tracking (0) | Cite |

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Transverse incision with longitudinal ligation procedure: Innovation, pitfalls, and clinical perspectives

Hong-Wei Hua, Jiong Wu

World J Gastroenterol 31(48):114738. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.114738

Abstract (69) | Core Tip (51) | Full Article (HTML) (196) | Full Article (PDF)-354K (37) | Full Article with Cover (PDF)-630K (24) | Full Article (XML)-40K (42) | Audio-633K (5) | Peer-Review Report-244K (23) | Answering Reviewers-70K (23) | Received: 09/26/2025 | Revised: 11/03/2025 | Accepted: 11/13/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (916) | Similar Articles (1) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Unmasking the high-risk phenotype in autoimmune gastritis: A pathologist’s roadmap for the clinician

Cheng-Long Wang, Min Zeng, Yan Luo

World J Gastroenterol 31(48):115244. Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.115244

Abstract (60) | Core Tip (58) | Full Article (HTML) (237) | Figures (1-1) (43) | Full Article (PDF)-3407K (64) | Full Article with Cover (PDF)-3681K (25) | Full Article (XML)-50K (26) | Audio-931K (4) | Peer-Review Report-169K (22) | Answering Reviewers-43K (26) | Received: 10/12/2025 | Revised: 10/28/2025 | Accepted: 11/12/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (948) | Similar Articles (11) | Timeline of Article Publication (3) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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