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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2025; 31(48): 112004
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.112004
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.112004
Sphinganine inhibits macrophage polarization and protects against sepsis-induced intestinal injury
Yi-Fan Chen, Jian-Guo Tang, Bai-Yin Zhang, Department of Trauma-Emergency and Critical Care Medicine Center, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China
Ze-Tian Wang, Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200240, China
Jian Zhao, Department of Emergency, Shanghai Tenth People’s Hospital, Shanghai 200072, China
Co-corresponding authors: Jian-Guo Tang and Bai-Yin Zhang.
Author contributions: Zhang BY and Tang JG designed the research study; Zhao J and Wang ZT performed the research, contributed new reagents and analytic tools; Chen YF analyzed the data and wrote the manuscript; all authors have read and approved the final manuscript.
Supported by the Natural Science of Minhang District of Shanghai, No. 2023MH2085.
Institutional review board statement: This study does not involve any human experiments.
Institutional animal care and use committee statement: All animal studies were performed at the Animal Experiment Center of East China Normal University with approval from the Experimental Animal Ethical Review Committee at East China Normal University (No. R20211202).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: Not applicable.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bai-Yin Zhang, PhD, Professor, Department of Trauma-Emergency and Critical Care Medicine Center, Shanghai Fifth People’s Hospital, Fudan University, No. 801 Heqing Road, Minhang District, Shanghai 200240, China. boyinercheung@hotmail.com
Received: July 23, 2025
Revised: September 20, 2025
Accepted: November 10, 2025
Published online: December 28, 2025
Processing time: 157 Days and 16.7 Hours
Revised: September 20, 2025
Accepted: November 10, 2025
Published online: December 28, 2025
Processing time: 157 Days and 16.7 Hours
Core Tip
Core Tip: This study reveals that sphinganine protects against sepsis-induced intestinal injury by inhibiting toll like receptor 2/nuclear factor kappa-B signaling, modulating macrophage polarization toward the M2 phenotype, and preserving intestinal barrier integrity.