Gut microbiota: An overlooked target in dyslipidemia management

doi:10.3748/wjg.v31.i48.113178

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Dec 28, 2025 (publication date) through Dec 27, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastroenterol. Dec 28, 2025; 31(48): 113178
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.113178

Gut microbiota: An overlooked target in dyslipidemia management

Ammara Abdul Majeed, Amna Subhan Butt

Ammara Abdul Majeed, Amna Subhan Butt, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan

Author contributions: Majeed AA and Butt AS both reviewed the article, performed literature search and wrote the letter to the editor; Butt AS received the invitation for letter to the editor.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Amna Subhan Butt, Associate Professor, Department of Medicine, Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan. amna.subhan@aku.edu

Received: August 18, 2025
Revised: October 1, 2025
Accepted: November 3, 2025
Published online: December 28, 2025
Processing time: 131 Days and 11.7 Hours

Core Tip

Core Tip: Dyslipidemia has emerged as a leading modifiable risk factor for atherosclerotic, cardiovascular and hepatic diseases. Gut microbiota lipid metabolism interactions offer new opportunities for dyslipidemia management, but translating these insights into clinical practice requires more than compositional profiling. This letter emphasizes overlooked dimensions like circadian rhythm alignment, drug-microbe crosstalk, population-specific microbial patterns, and functional microbial signatures to guide precision, and context-aware strategies for cardiovascular risk reduction.