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Contents Volume 31 Issue 47 December 21, 2025

Editorial

Resistance reversal: Taiwan’s Helicobacter pylori trends defy global norms

Taly Issa, Pierre Zalloua, Iyad A Issa

World J Gastroenterol 31(47):114789. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.114789

Abstract (70) | Core Tip (65) | Full Article (HTML) (417) | Figures (1-1) (45) | Full Article (PDF)-1332K (73) | Full Article with Cover (PDF)-1585K (28) | Full Article (XML)-77K (30) | Audio-1174K (9) | Peer-Review Report-153K (28) | Answering Reviewers-23K (30) | Received: 09/27/2025 | Revised: 10/05/2025 | Accepted: 10/31/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1382) | Similar Articles (32) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Review

Foundation models: Insights and implications for gastrointestinal cancer

Lei Shi, Rui Huang, Li-Ling Zhao, An-Jie Guo

World J Gastroenterol 31(47):112921. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.112921

Abstract (73) | Core Tip (73) | Full Article (HTML) (462) | Figures (1-1) (48) | Tables (1-6) (80) | Full Article (PDF)-1365K (934) | Full Article with Cover (PDF)-1618K (39) | Full Article (XML)-565K (30) | Audio-300K (18) | Peer-Review Report-253K (36) | Answering Reviewers-228K (51) | Supplementary Material-1041K (34) | Received: 08/09/2025 | Revised: 09/10/2025 | Accepted: 11/03/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2305) | Similar Articles (0) | Timeline of Article Publication (5) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Minireviews

Artificial intelligence applications for managing metabolic dysfunction-associated steatotic liver disease: Current status and future prospects

Jian-Jun Lou, Jing Zeng

World J Gastroenterol 31(47):111900. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.111900

Abstract (68) | Core Tip (67) | Full Article (HTML) (492) | Figures (1-1) (51) | Full Article (PDF)-1182K (175) | Full Article with Cover (PDF)-1436K (124) | Full Article (XML)-180K (28) | Audio-357K (16) | Peer-Review Report-245K (26) | Answering Reviewers-166K (28) | Received: 07/11/2025 | Revised: 10/07/2025 | Accepted: 11/05/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (1594) | Similar Articles (420) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Retrospective Study

Risk prediction of biliary infection after endoscopic drainage for malignant perihilar biliary obstruction: A 10-year multicenter retrospective study

Yi-Fei Wang, Ke Han, Na An, Ya-Nan Sun, Feng Gao, Yong Sun, Di Zhang, Zhi-Feng Zhao, Qing Guo, Jiang-Ning Gu, Zhuo Yang

World J Gastroenterol 31(47):113156. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.113156

Abstract (70) | Core Tip (58) | Full Article (HTML) (285) | Figures (1-3) (50) | Tables (1-3) (46) | Full Article (PDF)-1081K (62) | Full Article with Cover (PDF)-1334K (75) | Full Article (XML)-137K (30) | Audio-426K (12) | Peer-Review Report-177K (28) | Answering Reviewers-249K (27) | Supplementary Material-171K (25) | Received: 08/17/2025 | Revised: 09/16/2025 | Accepted: 10/28/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1924) | Similar Articles (0) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (1) | Cite |

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Feasibility and safety of enhanced recovery after surgery in elderly patients with gastric cancer

Jia-Yu Li, Miao-Miao Ge, Hua-Feng Pan, Gang Wang, Zhi-Wei Jiang

World J Gastroenterol 31(47):113331. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.113331

Abstract (79) | Core Tip (64) | Full Article (HTML) (281) | Tables (1-4) (67) | Full Article (PDF)-427K (42) | Full Article with Cover (PDF)-682K (83) | Full Article (XML)-97K (31) | Audio-3057K (11) | Peer-Review Report-284K (24) | Answering Reviewers-364K (22) | Supplementary Material-189K (25) | Received: 08/21/2025 | Revised: 09/22/2025 | Accepted: 10/29/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1934) | Similar Articles (1448) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Comparison of the prognostic value of different inflammation-based scores in patients with hepatocellular carcinoma after Lenvatinib therapy

Wei-Jie Wu, Ze-Yu Wu, Dan-Dan Hu, Zhong-Guo Zhou, Min-Shan Chen, Yao-Jun Zhang, Zhen-Yun Yang, Jin-Bin Chen

World J Gastroenterol 31(47):113776. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.113776

Abstract (68) | Core Tip (67) | Full Article (HTML) (325) | Figures (1-3) (54) | Tables (1-4) (42) | Full Article (PDF)-1699K (81) | Full Article with Cover (PDF)-1954K (86) | Full Article (XML)-107K (25) | Audio-244K (13) | Peer-Review Report-297K (26) | Answering Reviewers-270K (32) | Supplementary Material-160K (32) | Received: 09/02/2025 | Revised: 09/29/2025 | Accepted: 10/29/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (2088) | Similar Articles (1890) | Timeline of Article Publication (3) | Authors Evaluation (2) | Article Quality Tracking (0) | Cite |

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Interpretable machine learning model for early complication prediction after split liver transplantation

Di Wang, Jun-Yan Zhang, Yan Xie, Kun-Ning Zhang, Wen-Tao Jiang

World J Gastroenterol 31(47):114370. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.114370

Abstract (76) | Core Tip (68) | Full Article (HTML) (312) | Figures (1-5) (51) | Tables (1-2) (46) | Full Article (PDF)-2329K (58) | Full Article with Cover (PDF)-2583K (97) | Full Article (XML)-158K (30) | Audio-1838K (8) | Peer-Review Report-221K (32) | Answering Reviewers-127K (29) | Supplementary Material-267K (27) | Received: 09/20/2025 | Revised: 10/07/2025 | Accepted: 11/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (3371) | Similar Articles (135) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Pancreatic steatosis is not associated with advanced steatohepatitis or fibrosis in metabolic dysfunction-associated steatotic liver disease

Gabriel Heymann, Saumik Rahman, Daniel Kats, Bubu A Banini, Srinivas Gaddam, Elise Aslanian, Sarpong Boateng, Gary Israel, Thiruvengadam Muniraj

World J Gastroenterol 31(47):114651. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.114651

Abstract (73) | Core Tip (62) | Full Article (HTML) (334) | Figures (1-4) (51) | Tables (1-3) (60) | Full Article (PDF)-795K (81) | Full Article with Cover (PDF)-1050K (33) | Full Article (XML)-96K (33) | Audio-440K (14) | Peer-Review Report-273K (29) | Answering Reviewers-52K (31) | Received: 09/26/2025 | Revised: 10/19/2025 | Accepted: 11/03/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (1973) | Similar Articles (200) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Observational Study

Postoperative depression and anxiety in patients undergoing intestinal tumor surgery: Incidence, predictors, and impact on quality of life

Zhi-Jian Wei, Pei-Pei Liang, A-Man Xu

World J Gastroenterol 31(47):111599. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.111599

Abstract (64) | Core Tip (64) | Full Article (HTML) (330) | Figures (1-4) (47) | Tables (1-9) (59) | Full Article (PDF)-964K (69) | Full Article with Cover (PDF)-1216K (32) | Full Article (XML)-124K (38) | Audio-167K (13) | Peer-Review Report-219K (26) | Answering Reviewers-175K (22) | Received: 08/01/2025 | Revised: 09/08/2025 | Accepted: 11/07/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2177) | Similar Articles (158) | Timeline of Article Publication (1) | Article Quality Tracking (0) | Cite |

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Sex-based differences in hepatitis delta virus infection: Insights from the Italian PITER hepatitis delta virus cohort

Barbara Coco, Maria Giovanna Quaranta, Maria Elena Tosti, Luigina Ferrigno, Giuseppina Brancaccio, Alessia Ciancio, Carmine Coppola, Vincenzo Messina, Ivan Gentile, Ernesto Claar, Filomena Morisco, Teresa Santantonio, Mauro Viganò, Irene Cacciola, Maurizio Pompili, Francesco Paolo Russo, Antonio Izzi, Grazia A Niro, Nicola Coppola, Alessandro Soria, Alessandro Federico, Giulia Morsica, Massimo Puoti, Erica Villa, Pietro Lampertico, Giovanni Battista Gaeta, Loreta A Kondili, Maurizia R Brunetto, PITER Collaborating Investigators

World J Gastroenterol 31(47):111637. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.111637

Abstract (79) | Core Tip (66) | Full Article (HTML) (524) | Figures (1-4) (72) | Tables (1-4) (50) | Full Article (PDF)-1164K (113) | Full Article with Cover (PDF)-1417K (37) | Full Article (XML)-149K (41) | Audio-2178K (10) | Peer-Review Report-220K (23) | Answering Reviewers-205K (25) | Supplementary Material-115K (25) | Received: 07/04/2025 | Revised: 07/30/2025 | Accepted: 11/07/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (3062) | Similar Articles (7) | Timeline of Article Publication (1) | Authors Evaluation (2) | Article Quality Tracking (0) | Cite |

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Randomized Controlled Trial

Regional multi-center randomized trial of three vonoprazan-amoxicillin dosing regimens for Helicobacter pylori eradication in Sichuan Province, China

Chao-Qun Wu, Xiu Zhou, Chang-Ping Li, Qing-Ling He, Zong-Hua Chen, Shun-Bin Ding, Lei Deng, Lin-Lin Chen, Kai Jiang, Cheng-Kui Dong, Lian Hu, Guo-Bing Zhu, Cheng-Gang Zhang, Yan Zhang, Li-Li Wu, Wei Li, Yi-Hong Mao, Hua Zhang, Xia Ai, Yuan-Qing He, Yan Ma, Shuang-Yan He

World J Gastroenterol 31(47):114377. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.114377

Abstract (87) | Core Tip (82) | Full Article (HTML) (509) | Figures (1-1) (50) | Tables (1-5) (52) | Full Article (PDF)-555K (77) | Full Article with Cover (PDF)-808K (164) | Full Article (XML)-125K (27) | Audio-794K (9) | Peer-Review Report-237K (32) | Answering Reviewers-163K (23) | Received: 09/17/2025 | Revised: 10/11/2025 | Accepted: 11/06/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (2505) | Similar Articles (18) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Basic Study

Tumor necrosis factor-α promotes abnormal glucose metabolism after acute pancreatitis by inducing islet β-cell apoptosis via Bax/Bcl-2/caspase-3 signaling pathway

Hai-Feng Chen, Chen Gong, Ting-Ting Wang, Jian-Xin Zhu, Wei-Ping Li

World J Gastroenterol 31(47):113205. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.113205

Abstract (81) | Core Tip (62) | Full Article (HTML) (397) | Figures (1-5) (51) | Tables (1-1) (45) | Full Article (PDF)-6819K (69) | Full Article with Cover (PDF)-7073K (69) | Full Article (XML)-114K (31) | Audio-784K (10) | Peer-Review Report-261K (27) | Answering Reviewers-122K (29) | Supplementary Material-130K (32) | Received: 08/18/2025 | Revised: 09/29/2025 | Accepted: 11/07/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (2369) | Similar Articles (552) | Timeline of Article Publication (8) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Saffron and Calculus bovis combination exerts anti-hepatic fibrotic effect in liver fibrosis rats via the mitogen-activated protein kinases pathway

Sheng-Nan Sun, Kun Wang, Ya Xu, Fei Ye, Wei-Na Xia, Zhu-Wei Wang, Fang Liu, Zi-Xuan He, Meng Chen, Qing-Hong Du

World J Gastroenterol 31(47):113496. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.113496

Abstract (70) | Core Tip (69) | Full Article (HTML) (369) | Figures (1-6) (50) | Tables (1-2) (49) | Full Article (PDF)-21737K (130) | Full Article with Cover (PDF)-21990K (32) | Full Article (XML)-126K (29) | Audio-926K (11) | Peer-Review Report-343K (28) | Answering Reviewers-192K (35) | Received: 08/27/2025 | Revised: 10/11/2025 | Accepted: 11/11/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2624) | Similar Articles (153) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Case Report

Indolent T-cell lymphoma of the gastrointestinal tract coexisting with gastric signet-ring cell carcinoma: A case report and review of literature

Xue Chen, Jia-Qi Bo, Xiao-Xiang Gao, Su-Xia Zhang, Jie Li, Hui Wang, Mu-Ye Yang, Qian-Qian Guo, Bing Xiu, Yu Zeng

World J Gastroenterol 31(47):112705. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.112705

Abstract (68) | Core Tip (52) | Full Article (HTML) (388) | Figures (1-2) (48) | Tables (1-2) (56) | Full Article (PDF)-21017K (73) | Full Article with Cover (PDF)-21267K (42) | Full Article (XML)-110K (34) | Audio-1677K (9) | Peer-Review Report-491K (31) | Answering Reviewers-343K (30) | Received: 08/18/2025 | Revised: 09/28/2025 | Accepted: 11/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1492) | Similar Articles (4596) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Dual biologic therapy in patient with refractory ulcerative colitis and comorbidities: A case report

Andreia C Guimarães, Rocio Ferreiro-Iglesias, Cristina Calviño-Suarez, Iria Baston-Rey, Manuel Barreiro-de Acosta

World J Gastroenterol 31(47):113381. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.113381

Abstract (68) | Core Tip (69) | Full Article (HTML) (429) | Figures (1-1) (52) | Full Article (PDF)-589K (78) | Full Article with Cover (PDF)-844K (92) | Full Article (XML)-39K (47) | Audio-845K (9) | Peer-Review Report-463K (26) | Answering Reviewers-82K (27) | Received: 08/23/2025 | Revised: 09/27/2025 | Accepted: 11/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2022) | Similar Articles (4544) | Timeline of Article Publication (0) | Article Quality Tracking (1) | Cite |

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Letter to the Editor

Insertion time as a proxy for procedural complexity: Refining its role in predictive models of adenoma detection

Predrag Jovanovic

World J Gastroenterol 31(47):114092. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.114092

Abstract (62) | Core Tip (55) | Full Article (HTML) (287) | Full Article (PDF)-324K (51) | Full Article with Cover (PDF)-583K (27) | Full Article (XML)-18K (25) | Audio-505K (11) | Peer-Review Report-243K (20) | Answering Reviewers-179K (25) | Received: 09/10/2025 | Revised: 09/18/2025 | Accepted: 11/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1586) | Similar Articles (0) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Prognostic impact of tumor deposits in colorectal cancer

Bilal Turan

World J Gastroenterol 31(47):114506. Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.114506

Abstract (67) | Core Tip (69) | Full Article (HTML) (434) | Full Article (PDF)-371K (113) | Full Article with Cover (PDF)-628K (30) | Full Article (XML)-31K (26) | Audio-640K (15) | Peer-Review Report-351K (29) | Answering Reviewers-109K (30) | Received: 09/20/2025 | Revised: 10/18/2025 | Accepted: 10/29/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1316) | Similar Articles (1145) | Timeline of Article Publication (5) | Article Quality Tracking (1) | Cite |

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