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Contents Volume 31 Issue 46 December 14, 2025

Editorial

Levodopa and the dopamine receptor D1-Hippo/yes-associated protein axis: A novel therapeutic avenue for liver fibrosis

Shan-Shan Xie, Zhi-Gang Liu

World J Gastroenterol 31(46):113298. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.113298

Abstract (66) | Core Tip (56) | Full Article (HTML) (315) | Tables (1-1) (45) | Full Article (PDF)-385K (62) | Full Article with Cover (PDF)-732K (37) | Full Article (XML)-82K (30) | Audio-1333K (14) | Peer-Review Report-249K (28) | Answering Reviewers-125K (91) | Received: 08/20/2025 | Revised: 10/09/2025 | Accepted: 10/31/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1806) | Similar Articles (158) | Timeline of Article Publication (2) | Article Quality Tracking (0) | Cite |

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Review

Artificial intelligence in hepatopathy diagnosis and treatment: Big data analytics, deep learning, and clinical prediction models

Jing-Ran Sun, Xiao-Ning Sun, Bing-Jiu Lu, Bao-Cheng Deng

World J Gastroenterol 31(46):111176. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.111176

Abstract (71) | Core Tip (57) | Full Article (HTML) (411) | Tables (1-2) (54) | Full Article (PDF)-545K (222) | Full Article with Cover (PDF)-889K (188) | Full Article (XML)-247K (27) | Audio-1928K (19) | Peer-Review Report-336K (25) | Answering Reviewers-189K (21) | Received: 06/27/2025 | Revised: 08/31/2025 | Accepted: 10/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1761) | Similar Articles (394) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Endo-hepatology: Bridging the gap between lumen and liver

Walaa Abdelhamed, Mohamed El-Kassas

World J Gastroenterol 31(46):113145. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.113145

Abstract (68) | Core Tip (54) | Full Article (HTML) (353) | Figures (1-2) (58) | Full Article (PDF)-2428K (117) | Full Article with Cover (PDF)-2772K (103) | Full Article (XML)-306K (28) | Audio-491K (8) | Peer-Review Report-170K (29) | Answering Reviewers-133K (30) | Received: 08/15/2025 | Revised: 09/16/2025 | Accepted: 10/28/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1391) | Similar Articles (1) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Application of stem cells in the precise diagnosis and treatment of liver diseases

Yuan-Xin Wang, Ya-Nian Ren, Shan-Shan Zhang, Shan Sun, Ming-Yi Xu, Teng Wei, Lei-Sheng Zhang

World J Gastroenterol 31(46):114415. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.114415

Abstract (74) | Core Tip (61) | Full Article (HTML) (515) | Figures (1-4) (60) | Tables (1-4) (51) | Full Article (PDF)-3585K (72) | Full Article with Cover (PDF)-3930K (264) | Full Article (XML)-528K (32) | Audio-1201K (12) | Peer-Review Report-266K (27) | Answering Reviewers-194K (101) | Received: 09/18/2025 | Revised: 10/14/2025 | Accepted: 10/29/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1831) | Similar Articles (110) | Timeline of Article Publication (0) | Article Quality Tracking (2) | Cite |

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Minireviews

Advances in endoscopic ultrasound-guided shear wave elastography: A comprehensive review of its clinical applications

Mattia Paratore, Sara Miliani, Giulia D’Acunzo, Nicholas Viceconti, Silvia Andaloro, Giuseppe Cerniglia, Fabrizio Mancuso, Elena Melita, Gianenrico Rizzatti, Antonio Gasbarrini, Laura Riccardi, Matteo Garcovich

World J Gastroenterol 31(46):113585. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.113585

Abstract (62) | Core Tip (52) | Full Article (HTML) (392) | Figures (1-2) (44) | Tables (1-2) (52) | Full Article (PDF)-2098K (76) | Full Article with Cover (PDF)-2444K (101) | Full Article (XML)-151K (28) | Audio-972K (29) | Peer-Review Report-237K (32) | Answering Reviewers-174K (41) | Received: 08/28/2025 | Revised: 10/12/2025 | Accepted: 10/31/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1523) | Similar Articles (233) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Case Control Study

Development and validation of a nomogram incorporating dietary factors for predicting Helicobacter pylori-negative early gastric cancer risk

Xin-Yuan Liu, Yan-Qi Wang, Peng Li, Shu-Tian Zhang, Xiu-Jing Sun

World J Gastroenterol 31(46):112791. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.112791

Abstract (63) | Core Tip (52) | Full Article (HTML) (275) | Figures (1-3) (44) | Tables (1-4) (46) | Full Article (PDF)-1738K (77) | Full Article with Cover (PDF)-2084K (61) | Full Article (XML)-173K (28) | Audio-768K (22) | Peer-Review Report-287K (34) | Answering Reviewers-334K (34) | Supplementary Material-652K (36) | Received: 08/05/2025 | Revised: 09/19/2025 | Accepted: 10/30/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2864) | Similar Articles (175) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Serum C-X-C motif chemokine ligand 9, interleukin 8, and interleukin 22 as key biomarkers in pediatric inflammatory bowel disease

Adi Eindor-Abarbanel, Kevin Tsai, Ash Sandhu, Bruce Vallance, Kevan Jacobson

World J Gastroenterol 31(46):113172. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.113172

Abstract (90) | Core Tip (58) | Full Article (HTML) (248) | Figures (1-1) (42) | Tables (1-4) (44) | Full Article (PDF)-802K (51) | Full Article with Cover (PDF)-1149K (33) | Full Article (XML)-111K (33) | Audio-1015K (7) | Peer-Review Report-267K (28) | Answering Reviewers-199K (25) | Supplementary Material-220K (41) | Received: 08/17/2025 | Revised: 09/09/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1653) | Similar Articles (4) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Retrospective Cohort Study

Transarterial chemoembolization outcomes for advanced hepatocellular carcinoma vs sorafenib and best supportive care in a sub-Saharan African cohort

Sanju Sobnach, Karla Christina Sousa Silva, Ebtesam Abdel-Rashid Abdel-Shafy, Muhammad Emmamally, Catherine Wendy Spearman, Marc Bernon, Mark W Sonderup, Keith Venter, Inae Kim, Urda Kotze, Rajshree Segobin, Dale K Creamer, Stefano Cacciatore, Luiz Fernando Zerbini, Eduard Jonas

World J Gastroenterol 31(46):112249. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.112249

Abstract (74) | Core Tip (57) | Full Article (HTML) (365) | Figures (1-3) (42) | Tables (1-1) (45) | Full Article (PDF)-2905K (86) | Full Article with Cover (PDF)-3252K (74) | Full Article (XML)-184K (37) | Audio-2231K (12) | Peer-Review Report-335K (34) | Answering Reviewers-391K (26) | Supplementary Material-502K (41) | Received: 07/22/2025 | Revised: 09/09/2025 | Accepted: 10/31/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (2927) | Similar Articles (2009) | Timeline of Article Publication (1) | Article Quality Tracking (0) | Cite |

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Observational Study

Decoding Alexander the Great’s gastrointestinal cause of death using artificial wisdom: An artificial intelligence-human inquiry into a medical mystery

An-Lai Zhou, Joelle Yee-Hui Chiang, Kai Siang Chan, Nicole Tan, Vishal G Shelat

World J Gastroenterol 31(46):111669. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.111669

Abstract (82) | Core Tip (57) | Full Article (HTML) (496) | Figures (1-1) (49) | Tables (1-3) (66) | Full Article (PDF)-531K (103) | Full Article with Cover (PDF)-876K (28) | Full Article (XML)-140K (25) | Audio-2193K (17) | Peer-Review Report-222K (22) | Answering Reviewers-200K (28) | Supplementary Material-4133K (32) | Received: 07/06/2025 | Revised: 08/04/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2804) | Similar Articles (381) | Timeline of Article Publication (0) | Authors Evaluation (2) | Article Quality Tracking (0) | Cite |

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Prospective Study

Clinical utility of telomeres as diagnostic and short-term prognostic markers in loco-regional treatment of hepatocellular carcinoma

Sarah El-Nakeep, Hossameldin AbdelAziz, Tari George Michael, Ahmed Mohamed ElGhandour, Hoda A Abdelsattar, Fatma Mohamed Rafat Awad, Anup Kasi

World J Gastroenterol 31(46):112530. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.112530

Abstract (65) | Core Tip (50) | Full Article (HTML) (302) | Figures (1-6) (44) | Tables (1-10) (48) | Full Article (PDF)-1198K (63) | Full Article with Cover (PDF)-1543K (64) | Full Article (XML)-164K (35) | Audio-1304K (8) | Peer-Review Report-305K (28) | Answering Reviewers-739K (50) | Supplementary Material-65K (36) | Received: 07/29/2025 | Revised: 09/23/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2178) | Similar Articles (1876) | Timeline of Article Publication (1) | Authors Evaluation (3) | Article Quality Tracking (0) | Cite |

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Basic Study

IGF2BP3 binds to FBXO32 to activate the cyclic guanosine monophosphate-protein kinase G pathway, promoting gastric cancer progression

Yi Si, Bo Tian, Rui Zhang, Ming-Da Xuan, Kun-Yi Liu, Jiao Jiao, Shuang-Shuang Han, Hong-Fei Li, Yan-Hong Hu, Hong-Yan Zhao, Wen-Jing He, Jia Wang, Ting Liu, Wei-Fang Yu

World J Gastroenterol 31(46):111631. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.111631

Abstract (61) | Core Tip (53) | Full Article (HTML) (348) | Figures (1-8) (51) | Tables (1-2) (42) | Full Article (PDF)-33320K (95) | Full Article with Cover (PDF)-33664K (56) | Full Article (XML)-170K (27) | Audio-485K (11) | Peer-Review Report-247K (35) | Answering Reviewers-1316K (28) | Supplementary Material-838K (32) | Received: 07/05/2025 | Revised: 09/21/2025 | Accepted: 10/24/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2904) | Similar Articles (1283) | Timeline of Article Publication (6) | Article Quality Tracking (0) | Cite |

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Ethnic genomic differences in esophageal squamous cell carcinoma: Whole-exome sequencing of Han and Kazakh populations in China

Meng-Xia Wei, Ling-Ling Lei, Rui-Hua Xu, Yong-Xuan Liu, Ran Wang, Wen-Li Han, Zong-Min Fan, Fan-Kai Xiao, Ilyar Sheyhidin, Lei Ma, Jian-Wei Ku, Ming-Zhu Yin, Ai-Fang Ji, Qi-De Bao, She-Gan Gao, Xue-Na Han, Xin-Min Li, Pei-Nan Chen, Xue-Ke Zhao, Xin Song, Li-Dong Wang

World J Gastroenterol 31(46):112664. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.112664

Abstract (74) | Core Tip (58) | Full Article (HTML) (300) | Figures (1-5) (41) | Full Article (PDF)-6049K (65) | Full Article with Cover (PDF)-6392K (35) | Full Article (XML)-252K (30) | Audio-1080K (12) | Peer-Review Report-190K (27) | Answering Reviewers-228K (34) | Supplementary Material-182K (31) | Received: 08/02/2025 | Revised: 09/17/2025 | Accepted: 11/03/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1798) | Similar Articles (116) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Meta-Analysis

Epidemiology of metabolic dysfunction-associated steatotic liver disease/metabolic dysfunction-associated steatohepatitis and associated cardiometabolic factors in adults in China (2013-2023): A systematic review and meta-analysis

Shang-Yu Chai, Ru-Ya Zhang, Gail Fernandes, Yi-Man Zheng, Lai Wei

World J Gastroenterol 31(46):113608. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.113608

Abstract (108) | Core Tip (68) | Full Article (HTML) (929) | Figures (1-6) (57) | Tables (1-2) (59) | Full Article (PDF)-3605K (214) | Full Article with Cover (PDF)-3949K (43) | Full Article (XML)-179K (86) | Audio-1440K (19) | Peer-Review Report-246K (31) | Answering Reviewers-196K (36) | Supplementary Material-1540K (236) | Received: 08/29/2025 | Revised: 09/23/2025 | Accepted: 10/31/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (2878) | Similar Articles (859) | Timeline of Article Publication (2) | Article Quality Tracking (0) | Cite |

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Case Report

Beyond the skin - metastatic basal cell carcinoma in the stomach: A case report

Shukria Ahmadi, Ishraq Joarder, Fahd Jowhari

World J Gastroenterol 31(46):112010. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.112010

Abstract (62) | Core Tip (54) | Full Article (HTML) (441) | Figures (1-2) (50) | Full Article (PDF)-3294K (94) | Full Article with Cover (PDF)-3640K (43) | Full Article (XML)-46K (26) | Audio-308K (11) | Peer-Review Report-274K (24) | Answering Reviewers-85K (27) | Received: 07/16/2025 | Revised: 08/05/2025 | Accepted: 10/31/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1355) | Similar Articles (4546) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Letter to the Editor

Additional considerations on vonoprazan triple therapy for Helicobacter pylori eradication: Implementation challenges and clinical perspectives

Chu-Ying Sun, Ming-Xian Chen

World J Gastroenterol 31(46):113528. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.113528

Abstract (80) | Core Tip (51) | Full Article (HTML) (288) | Full Article (PDF)-351K (61) | Full Article with Cover (PDF)-699K (47) | Full Article (XML)-31K (29) | Audio-1891K (6) | Peer-Review Report-177K (28) | Answering Reviewers-132K (30) | Received: 08/27/2025 | Revised: 10/02/2025 | Accepted: 11/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1106) | Similar Articles (12) | Timeline of Article Publication (3) | Article Quality Tracking (0) | Cite |

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Gastric varices management: Is clip-assisted glue injection a real-world alternative to endoscopic ultrasound-guided therapy?

Suprabhat Giri, Kshitij Kumar

World J Gastroenterol 31(46):114149. Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.114149

Abstract (64) | Core Tip (61) | Full Article (HTML) (300) | Tables (1-1) (48) | Full Article (PDF)-353K (87) | Full Article with Cover (PDF)-703K (29) | Full Article (XML)-36K (30) | Audio-689K (8) | Peer-Review Report-243K (32) | Answering Reviewers-82K (30) | Received: 09/12/2025 | Revised: 10/19/2025 | Accepted: 10/31/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1245) | Similar Articles (307) | Timeline of Article Publication (1) | Article Quality Tracking (1) | Cite |

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