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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2025; 31(46): 113585
Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.113585
Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.113585
Advances in endoscopic ultrasound-guided shear wave elastography: A comprehensive review of its clinical applications
Mattia Paratore, Sara Miliani, Giulia D’Acunzo, Nicholas Viceconti, Silvia Andaloro, Giuseppe Cerniglia, Fabrizio Mancuso, Elena Melita, Laura Riccardi, Matteo Garcovich, Diagnostic and Interventional Ultrasound Unit, CEMAD Digestive Disease Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome 00168, Italy
Gianenrico Rizzatti, Digestive Endoscopy Unit, CEMAD Digestive Disease Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome 00168, Italy
Antonio Gasbarrini, Internal Medicine and Gastroenterology Unit, CEMAD Digestive Disease Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome 00168, Italy
Antonio Gasbarrini, Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome 00168, Italy
Author contributions: Paratore M, Riccardi L, and Garcovich M contributed to review design, investigation, and supervision; all authors contributed to conceptualization, writing first draft and editing; all authors revised the manuscript critically for intellectual content and approved the final version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Matteo Garcovich, MD, PhD, Diagnostic and Interventional Ultrasound Unit, CEMAD Digestive Disease Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Rome 00168, Italy.
Received: August 29, 2025
Revised: October 12, 2025
Accepted: October 31, 2025
Published online: December 14, 2025
Processing time: 103 Days and 7.8 Hours
Revised: October 12, 2025
Accepted: October 31, 2025
Published online: December 14, 2025
Processing time: 103 Days and 7.8 Hours
Core Tip
Core Tip: Endoscopic ultrasound (EUS)-guided shear wave elastography provides real-time, quantitative assessment of tissue stiffness during standard EUS examinations. Current evidence supports its value in staging chronic pancreatitis, monitoring autoimmune pancreatitis, and assessing liver fibrosis with diagnostic accuracy comparable to vibration-controlled transient elastography. While feasibility and reproducibility are consistently high, the lack of standardized protocols and validated cut-off values limits routine application. Large-scale prospective studies are essential to define its role in clinical practice and establish EUS-shear wave elastography as a reliable tool in precision gastroenterology.