Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2025; 31(46): 112791
Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.112791
Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.112791
Development and validation of a nomogram incorporating dietary factors for predicting Helicobacter pylori-negative early gastric cancer risk
Xin-Yuan Liu, Yan-Qi Wang, Peng Li, Shu-Tian Zhang, Xiu-Jing Sun, Department of Gastroen
Co-first authors: Xin-Yuan Liu and Yan-Qi Wang.
Author contributions: Liu XY and Wang YQ were responsible for the collection and assembly of data, data analysis and interpretation, and manuscript writing, they made equal contributions as co-first authors; Li P and Zhang ST were responsible for statistic expertise; Sun XJ was responsible for revising the manuscript and financial support. All authors have read and approved the final version of the manuscript.
Supported by National Key Research and Development Program of China, No. 2022YFC3602104; National Natural Science Foundation of China, No. 82470576; and Capital Medical University Outstanding Young Talents A Class Project, No. A2408.
Institutional review board statement: This study was approved by the Ethics Committee of Beijing Friendship Hospital, Capital Medical University, No. 2018-P2-058-01.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: All data analyzed during this study are included in this article. Further enquiries can be directed to the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiu-Jing Sun, MD, Chief Physician, Professor, Department of Gas
Received: August 6, 2025
Revised: September 19, 2025
Accepted: October 30, 2025
Published online: December 14, 2025
Processing time: 126 Days and 12.7 Hours
Revised: September 19, 2025
Accepted: October 30, 2025
Published online: December 14, 2025
Processing time: 126 Days and 12.7 Hours
Core Tip
Core Tip: Early gastric cancer (EGC), especially Helicobacter pylori (H. pylori)-negative EGC, often goes unnoticed because of the absence of obvious clinical symptoms in patients. Our study explored the risk and protective factors associated with the development of H. pylori-negative EGC, and established a risk prediction model. The model, established based on advanced age, digestive comorbidities, and the frequent consumption of smoked and hot foods, legumes and nuts, has superior accuracy and clinical application value.