Abdelhamed W, El-Kassas M. Endo-hepatology: Bridging the gap between lumen and liver. World J Gastroenterol 2025; 31(46): 113145 [DOI: 10.3748/wjg.v31.i46.113145]
Corresponding Author of This Article
Mohamed El-Kassas, MD, Full Professor, Department of Endemic Medicine, Faculty of Medicine, Helwan University, Ain Helwan, Cairo 11795, Egypt. m_elkassas@med.helwan.edu.eg
Research Domain of This Article
Gastroenterology & Hepatology
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Review
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 14, 2025 (publication date) through Dec 10, 2025
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Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Abdelhamed W, El-Kassas M. Endo-hepatology: Bridging the gap between lumen and liver. World J Gastroenterol 2025; 31(46): 113145 [DOI: 10.3748/wjg.v31.i46.113145]
World J Gastroenterol. Dec 14, 2025; 31(46): 113145 Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.113145
Endo-hepatology: Bridging the gap between lumen and liver
Walaa Abdelhamed, Mohamed El-Kassas
Walaa Abdelhamed, Department of Endemic Medicine, Sohag University, Sohag 14322, Egypt
Mohamed El-Kassas, Department of Endemic Medicine, Faculty of Medicine, Helwan University, Cairo 11795, Egypt
Mohamed El-Kassas, Applied Science Research Center, Applied Science Private University, Amman 11931, Jordan
Co-first authors: Walaa Abdelhamed and Mohamed El-Kassas.
Author contributions: Abdelhamed W drafted the manuscript; El-Kassas M conceptualized the idea and revised the final manuscript; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohamed El-Kassas, MD, Full Professor, Department of Endemic Medicine, Faculty of Medicine, Helwan University, Ain Helwan, Cairo 11795, Egypt. m_elkassas@med.helwan.edu.eg
Received: August 18, 2025 Revised: September 16, 2025 Accepted: October 28, 2025 Published online: December 14, 2025 Processing time: 116 Days and 13.8 Hours
Abstract
In recent years, hepatology has undergone a transformative evolution driven by significant advancements in diagnostic and therapeutic technologies. The expanding integration of endoscopic modalities into hepatology has enforced the diagnosis, staging, management of liver diseases beside integration into transplantation. This review highlights the evolving discipline of “endo-hepatology”, where endoscopic ultrasound, endoscopic retrograde cholangiopancreatography, and novel interventional tools are employed to address the critical challenges in chronic liver disease. The review provides a comprehensive synthesis of current evidence and different clinical applications, while also exploring future directions including revolution of artificial intelligence-assisted endoscopies and enhanced imaging endoscopies. By bridging the anatomical and functional interface between the gastrointestinal lumen and the liver, endo-hepatology is not only improving diagnostic accuracy and therapeutic precision but also reshaping multidisciplinary paradigms in hepatology practice.
Core Tip: Endo-hepatology bridges hepatology and advanced endoscopy, offering minimally invasive, precise tools for managing complex liver conditions. This review outlines key roles of endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography in evaluating portal hypertension, biliary complications, steatotic liver disease, and liver tumors. It also discusses novel methods like EUS-guided portal pressure measurements and artificial intelligence-enhanced imaging. These innovations highlight the growing need for multidisciplinary training and collaborative research to improve patient care.
