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Contents Volume 31 Issue 44 November 28, 2025

Editorial

Redefining therapeutic thresholds and global guidelines: Toward precision management of intermediate-sized rectal neuroendocrine tumors

Dan Hu, Jiang Yu, Meng-Xue Wang, Hao-Ling Zhang

World J Gastroenterol 31(44):114263. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.114263

Abstract (120) | Core Tip (116) | Full Article (HTML) (485) | Tables (1-1) (101) | Full Article (PDF)-398K (120) | Full Article with Cover (PDF)-726K (164) | Full Article (XML)-75K (47) | Audio-222K (10) | Received: 09/14/2025 | Revised: 10/10/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (3) | Timeline of Article Publication (4) | Cite | (51) | (41) | (0) | (0) | (0) | (13) | (917) | (2) | Open

Review

Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway

Lie Zheng, Sheng-Lei Duan

World J Gastroenterol 31(44):109440. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.109440

Abstract (98) | Core Tip (103) | Full Article (HTML) (916) | Figures (1-3) (74) | Full Article (PDF)-1729K (142) | Full Article with Cover (PDF)-2056K (205) | Full Article (XML)-231K (40) | Audio-209K (15) | Received: 05/10/2025 | Revised: 08/07/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (691) | Timeline of Article Publication (2) | Cite | (53) | (43) | (0) | (0) | (0) | (2) | (1377) | (4) | Open

Role of artificial intelligence in the detection and characterization of gastrointestinal premalignant and early malignant lesions

Noelle El Asmar, Mariam Baydoun, Jamil Mrad, Kassem Barada

World J Gastroenterol 31(44):111160. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.111160

Abstract (120) | Core Tip (144) | Full Article (HTML) (1026) | Figures (1-3) (70) | Tables (1-9) (71) | Full Article (PDF)-927K (240) | Full Article with Cover (PDF)-1252K (272) | Full Article (XML)-654K (42) | Audio-804K (20) | Received: 06/24/2025 | Revised: 07/20/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (374) | Timeline of Article Publication (1) | Cite | (44) | (60) | (0) | (0) | (0) | (1721) | (2) | Open

Application of traditional Chinese medicine integrated therapy based on Tuina and herbal medicine in pediatric diarrhea

Yu Zhu, Hai-Cheng Dong, Yao Zhang, Xiao-Ai Wang, Jun-Yi Chen, Jing-Jing Wang

World J Gastroenterol 31(44):113017. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113017

Abstract (122) | Core Tip (130) | Full Article (HTML) (1061) | Figures (1-2) (75) | Tables (1-2) (103) | Full Article (PDF)-792K (203) | Full Article with Cover (PDF)-1119K (131) | Full Article (XML)-237K (50) | Audio-247K (52) | Received: 08/19/2025 | Revised: 09/18/2025 | Accepted: 10/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (221) | Timeline of Article Publication (4) | Cite | (52) | (98) | (0) | (0) | (0) | (20) | (1623) | (3) | Open

Advances in the study of the relationship between neurotransmitters and gastric cancer

You-Zhao Liu, Wen-Xuan Liu, Wen-Hong Deng

World J Gastroenterol 31(44):113793. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113793

Abstract (117) | Core Tip (108) | Full Article (HTML) (734) | Figures (1-3) (94) | Tables (1-1) (89) | Full Article (PDF)-2218K (197) | Full Article with Cover (PDF)-2546K (80) | Full Article (XML)-323K (57) | Audio-561K (23) | Supplementary Material-666K (44) | Received: 09/03/2025 | Revised: 09/20/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (1356) | Timeline of Article Publication (5) | Cite | (52) | (64) | (0) | (0) | (0) | (20) | (1251) | (3) | Open

Case Control Study

Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma

Yan-Fei Feng, Tu-Mei Su, Bo-Bin Hu, Hang Wang, Qing-Mei Li, Qian-Bing Yin, Long Huang, Hong-Qian Liang, Ao-Li Ren, Ming-Hua Su, Jian-Ning Jiang

World J Gastroenterol 31(44):112481. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112481

Abstract (98) | Core Tip (106) | Full Article (HTML) (394) | Figures (1-6) (87) | Tables (1-5) (74) | Full Article (PDF)-1405K (68) | Full Article with Cover (PDF)-1734K (84) | Full Article (XML)-120K (40) | Audio-325K (17) | Received: 07/28/2025 | Revised: 09/13/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (2312) | Timeline of Article Publication (5) | Cite | (57) | (52) | (0) | (0) | (0) | (14) | (1) | (747) | (2) | Open

Retrospective Cohort Study

Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B

Yan-Chao Fu, Jun Li, Jia-Yin Wang, Yi-Wen Zhang, Fei Yan, Jing Chen, Qin Du, Chao Yang, Jing Liang, Qing Ye, Hui-Ling Xiang

World J Gastroenterol 31(44):112719. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112719

Abstract (124) | Core Tip (107) | Full Article (HTML) (577) | Figures (1-5) (107) | Tables (1-2) (79) | Full Article (PDF)-1197K (93) | Full Article with Cover (PDF)-1526K (68) | Full Article (XML)-106K (40) | Audio-1375K (31) | Supplementary Material-116K (49) | Received: 08/04/2025 | Revised: 09/14/2025 | Accepted: 10/24/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (221) | Timeline of Article Publication (0) | Cite | (43) | (51) | (0) | (0) | (0) | (15) | (964) | (2) | Open

Retrospective Study

DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles

Ismail Taskiran, Seda Orenay-Boyacioglu, Olcay Boyacioglu, Ibrahim Halil Erdogdu, Nil Culhaci, Ibrahim Meteoglu

World J Gastroenterol 31(44):112524. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112524

Abstract (104) | Core Tip (99) | Full Article (HTML) (647) | Figures (1-2) (70) | Tables (1-5) (91) | Full Article (PDF)-680K (90) | Full Article with Cover (PDF)-1008K (91) | Full Article (XML)-142K (43) | Audio-258K (13) | Received: 07/29/2025 | Revised: 09/13/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (1230) | Timeline of Article Publication (2) | Cite | (48) | (101) | (0) | (0) | (0) | (15) | (1) | (1032) | (4) | Open

Risk factors with nomogram construction for moderate to severe pain after endoscopic full-thickness resection

Guo-Yao Sun, Teng-Jiao Gao, Yong Sun, Wen Jia, Zhuo Yang

World J Gastroenterol 31(44):112576. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112576

Abstract (117) | Core Tip (121) | Full Article (HTML) (386) | Figures (1-2) (68) | Tables (1-2) (65) | Full Article (PDF)-701K (73) | Full Article with Cover (PDF)-1030K (103) | Full Article (XML)-71K (43) | Audio-1620K (8) | Received: 07/30/2025 | Revised: 09/06/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (363) | Timeline of Article Publication (0) | Cite | (40) | (46) | (0) | (0) | (0) | (738) | Open

Clinical Trials Study

Influence of an internet-based proactive follow-up management model on the prognosis of nonalcoholic fatty liver disease

Sui-Yi Liu, Guo-Feng Gao, Xiao-Yu Wang, Jiao Yu

World J Gastroenterol 31(44):111731. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.111731

Abstract (103) | Core Tip (141) | Full Article (HTML) (406) | Tables (1-10) (71) | Full Article (PDF)-461K (82) | Full Article with Cover (PDF)-788K (55) | Full Article (XML)-94K (41) | Audio-1398K (11) | Received: 07/29/2025 | Revised: 09/14/2025 | Accepted: 10/28/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (306) | Timeline of Article Publication (0) | Cite | (49) | (50) | (0) | (0) | (0) | (655) | (2) | Open

Randomized Controlled Trial

Covering the biopsy hole check valve with “enzymolysis gauze” reduces bacterial contamination in the endoscopy room

Hu-Bin Xia, Ying-Dong Hou, Yuan Zhang, Ai-Yu Yu, Qi Ding, Wen-Li Ruan, Yi-Shen Mao, Shu-Jiong Feng, Cong Ding, Yi-Feng Zhou

World J Gastroenterol 31(44):113650. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113650

Abstract (112) | Core Tip (100) | Full Article (HTML) (367) | Figures (1-4) (75) | Tables (1-1) (69) | Full Article (PDF)-3332K (70) | Full Article with Cover (PDF)-3660K (58) | Full Article (XML)-91K (43) | Audio-1073K (15) | Received: 08/30/2025 | Revised: 10/10/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (147) | Timeline of Article Publication (0) | Cite | (45) | (42) | (0) | (0) | (0) | (682) | (1) | Open

Basic Study

Dexmedetomidine enhances anastomotic healing partly via the Wnt/β-catenin pathway in a rat model of colon surgery

Ying Chen, Chun-Tian Li, Jie-Bo Wang, Wen-Lu Tang, Yu Zhao, Ye Chen, Lian-Ming Liao, Liang-Cheng Zhang, Tian-Hua Lin, Zhi-Fang Cao

World J Gastroenterol 31(44):112833. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112833

Abstract (102) | Core Tip (98) | Full Article (HTML) (469) | Figures (1-8) (74) | Tables (1-1) (74) | Full Article (PDF)-39135K (81) | Full Article with Cover (PDF)-39463K (61) | Full Article (XML)-121K (60) | Audio-293K (18) | Received: 08/06/2025 | Revised: 09/28/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (41) | Timeline of Article Publication (1) | Cite | (61) | (61) | (0) | (0) | (0) | (14) | (819) | Open

Case Report

Very-early-stage gastric amphicrine carcinoma with mixed histology: A case report and review of literature

Cai-Zhi Gao, Yuan Meng, Jin-Zhu Du, Xu Zhu

World J Gastroenterol 31(44):112187. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112187

Abstract (112) | Core Tip (100) | Full Article (HTML) (599) | Figures (1-6) (94) | Tables (1-1) (78) | Full Article (PDF)-30241K (113) | Full Article with Cover (PDF)-30570K (99) | Full Article (XML)-86K (44) | Audio-1338K (16) | Received: 07/29/2025 | Revised: 09/10/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (4682) | Timeline of Article Publication (5) | Cite | (43) | (50) | (0) | (0) | (0) | (17) | (1027) | (1) | Open

Letter to the Editor

Prudence is never excessive: Caution warranted in 5-aminosalicylic acid derivatives withdrawal for ulcerative colitis

Antonietta Gerarda Gravina, Raffaele Pellegrino, Alessandro Federico

World J Gastroenterol 31(44):113253. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113253

Abstract (105) | Core Tip (100) | Full Article (HTML) (518) | Full Article (PDF)-392K (81) | Full Article with Cover (PDF)-722K (161) | Full Article (XML)-48K (45) | Audio-244K (13) | Received: 08/19/2025 | Revised: 10/02/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (427) | Timeline of Article Publication (0) | Cite | (44) | (43) | (0) | (0) | (0) | (805) | Open

Risk elements and diagnostic indicators for asymptomatic immune checkpoint inhibitor-associated myocarditis in esophageal cancer

Tushar Bhadra, Brandon Lucke-Wold

World J Gastroenterol 31(44):113689. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113689

Abstract (118) | Core Tip (99) | Full Article (HTML) (360) | Full Article (PDF)-379K (71) | Full Article with Cover (PDF)-708K (45) | Full Article (XML)-39K (39) | Audio-6486K (28) | Received: 08/31/2025 | Revised: 09/25/2025 | Accepted: 10/16/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (183) | Timeline of Article Publication (0) | Cite | (55) | (54) | (0) | (0) | (0) | (16) | (515) | Open

Peroxiredoxin 1 inhibits tumorigenesis by activating the NLR family pyrin domain containing 3/gasdermin D pathway: Advanced therapies targeting heterogeneous cell death mechanisms

Anna Smirnova, Daria Eygel, Irina Kondrasheva, Denis S Baranovskii, Ilya D Klabukov

World J Gastroenterol 31(44):114404. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.114404

Abstract (123) | Core Tip (124) | Full Article (HTML) (365) | Full Article (PDF)-361K (60) | Full Article with Cover (PDF)-691K (62) | Full Article (XML)-39K (46) | Audio-62K (12) | Received: 09/17/2025 | Revised: 09/30/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (7) | Timeline of Article Publication (0) | Cite | (42) | (46) | (0) | (0) | (0) | (533) | Open

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