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Contents Volume 31 Issue 44 November 28, 2025

Editorial

Redefining therapeutic thresholds and global guidelines: Toward precision management of intermediate-sized rectal neuroendocrine tumors

Dan Hu, Jiang Yu, Meng-Xue Wang, Hao-Ling Zhang

World J Gastroenterol 31(44):114263. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.114263

Abstract (130) | Core Tip (125) | Full Article (HTML) (545) | Tables (1-1) (111) | Full Article (PDF)-398K (124) | Full Article with Cover (PDF)-726K (168) | Full Article (XML)-75K (54) | Audio-222K (14) | Received: 09/14/2025 | Revised: 10/10/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (3) | Timeline of Article Publication (4) | Cite | (55) | (45) | (0) | (0) | (0) | (18) | (1002) | (2) | Open

Review

Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway

Lie Zheng, Sheng-Lei Duan

World J Gastroenterol 31(44):109440. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.109440

Abstract (109) | Core Tip (112) | Full Article (HTML) (984) | Figures (1-3) (78) | Full Article (PDF)-1729K (145) | Full Article with Cover (PDF)-2056K (215) | Full Article (XML)-231K (48) | Audio-209K (16) | Received: 05/10/2025 | Revised: 08/07/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (692) | Timeline of Article Publication (2) | Cite | (59) | (46) | (0) | (0) | (0) | (2) | (1470) | (4) | Open

Role of artificial intelligence in the detection and characterization of gastrointestinal premalignant and early malignant lesions

Noelle El Asmar, Mariam Baydoun, Jamil Mrad, Kassem Barada

World J Gastroenterol 31(44):111160. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.111160

Abstract (133) | Core Tip (153) | Full Article (HTML) (1105) | Figures (1-3) (79) | Tables (1-9) (79) | Full Article (PDF)-927K (247) | Full Article with Cover (PDF)-1252K (280) | Full Article (XML)-654K (47) | Audio-804K (20) | Received: 06/24/2025 | Revised: 07/20/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (379) | Timeline of Article Publication (1) | Cite | (51) | (63) | (0) | (0) | (0) | (1837) | (2) | Open

Application of traditional Chinese medicine integrated therapy based on Tuina and herbal medicine in pediatric diarrhea

Yu Zhu, Hai-Cheng Dong, Yao Zhang, Xiao-Ai Wang, Jun-Yi Chen, Jing-Jing Wang

World J Gastroenterol 31(44):113017. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113017

Abstract (132) | Core Tip (141) | Full Article (HTML) (1147) | Figures (1-2) (82) | Tables (1-2) (109) | Full Article (PDF)-792K (208) | Full Article with Cover (PDF)-1119K (134) | Full Article (XML)-237K (52) | Audio-247K (54) | Received: 08/19/2025 | Revised: 09/18/2025 | Accepted: 10/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (222) | Timeline of Article Publication (4) | Cite | (56) | (103) | (0) | (0) | (0) | (21) | (1732) | (3) | Open

Advances in the study of the relationship between neurotransmitters and gastric cancer

You-Zhao Liu, Wen-Xuan Liu, Wen-Hong Deng

World J Gastroenterol 31(44):113793. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113793

Abstract (126) | Core Tip (123) | Full Article (HTML) (806) | Figures (1-3) (103) | Tables (1-1) (98) | Full Article (PDF)-2218K (203) | Full Article with Cover (PDF)-2546K (84) | Full Article (XML)-323K (65) | Audio-561K (23) | Supplementary Material-666K (46) | Received: 09/03/2025 | Revised: 09/20/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (1361) | Timeline of Article Publication (5) | Cite | (58) | (69) | (0) | (0) | (0) | (26) | (1359) | (3) | Open

Case Control Study

Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma

Yan-Fei Feng, Tu-Mei Su, Bo-Bin Hu, Hang Wang, Qing-Mei Li, Qian-Bing Yin, Long Huang, Hong-Qian Liang, Ao-Li Ren, Ming-Hua Su, Jian-Ning Jiang

World J Gastroenterol 31(44):112481. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112481

Abstract (107) | Core Tip (114) | Full Article (HTML) (433) | Figures (1-6) (92) | Tables (1-5) (79) | Full Article (PDF)-1405K (73) | Full Article with Cover (PDF)-1734K (87) | Full Article (XML)-120K (44) | Audio-325K (18) | Received: 07/28/2025 | Revised: 09/13/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (2314) | Timeline of Article Publication (5) | Cite | (63) | (55) | (0) | (0) | (0) | (19) | (1) | (808) | (2) | Open

Retrospective Cohort Study

Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B

Yan-Chao Fu, Jun Li, Jia-Yin Wang, Yi-Wen Zhang, Fei Yan, Jing Chen, Qin Du, Chao Yang, Jing Liang, Qing Ye, Hui-Ling Xiang

World J Gastroenterol 31(44):112719. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112719

Abstract (138) | Core Tip (121) | Full Article (HTML) (636) | Figures (1-5) (112) | Tables (1-2) (82) | Full Article (PDF)-1197K (105) | Full Article with Cover (PDF)-1526K (71) | Full Article (XML)-106K (46) | Audio-1375K (33) | Supplementary Material-116K (54) | Received: 08/04/2025 | Revised: 09/14/2025 | Accepted: 10/24/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (223) | Timeline of Article Publication (0) | Cite | (48) | (57) | (0) | (0) | (0) | (16) | (1052) | (2) | Open

Retrospective Study

DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles

Ismail Taskiran, Seda Orenay-Boyacioglu, Olcay Boyacioglu, Ibrahim Halil Erdogdu, Nil Culhaci, Ibrahim Meteoglu

World J Gastroenterol 31(44):112524. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112524

Abstract (118) | Core Tip (109) | Full Article (HTML) (692) | Figures (1-2) (75) | Tables (1-5) (97) | Full Article (PDF)-680K (99) | Full Article with Cover (PDF)-1008K (95) | Full Article (XML)-142K (50) | Audio-258K (15) | Received: 07/29/2025 | Revised: 09/13/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (1236) | Timeline of Article Publication (2) | Cite | (53) | (105) | (0) | (0) | (0) | (17) | (1) | (1108) | (4) | Open

Risk factors with nomogram construction for moderate to severe pain after endoscopic full-thickness resection

Guo-Yao Sun, Teng-Jiao Gao, Yong Sun, Wen Jia, Zhuo Yang

World J Gastroenterol 31(44):112576. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112576

Abstract (123) | Core Tip (132) | Full Article (HTML) (425) | Figures (1-2) (73) | Tables (1-2) (70) | Full Article (PDF)-701K (80) | Full Article with Cover (PDF)-1030K (106) | Full Article (XML)-71K (50) | Audio-1620K (9) | Received: 07/30/2025 | Revised: 09/06/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (370) | Timeline of Article Publication (0) | Cite | (44) | (47) | (0) | (0) | (0) | (804) | Open

Clinical Trials Study

Influence of an internet-based proactive follow-up management model on the prognosis of nonalcoholic fatty liver disease

Sui-Yi Liu, Guo-Feng Gao, Xiao-Yu Wang, Jiao Yu

World J Gastroenterol 31(44):111731. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.111731

Abstract (109) | Core Tip (151) | Full Article (HTML) (453) | Tables (1-10) (77) | Full Article (PDF)-461K (89) | Full Article with Cover (PDF)-788K (62) | Full Article (XML)-94K (46) | Audio-1398K (11) | Received: 07/29/2025 | Revised: 09/14/2025 | Accepted: 10/28/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (309) | Timeline of Article Publication (0) | Cite | (55) | (57) | (0) | (0) | (0) | (727) | (2) | Open

Randomized Controlled Trial

Covering the biopsy hole check valve with “enzymolysis gauze” reduces bacterial contamination in the endoscopy room

Hu-Bin Xia, Ying-Dong Hou, Yuan Zhang, Ai-Yu Yu, Qi Ding, Wen-Li Ruan, Yi-Shen Mao, Shu-Jiong Feng, Cong Ding, Yi-Feng Zhou

World J Gastroenterol 31(44):113650. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113650

Abstract (120) | Core Tip (110) | Full Article (HTML) (407) | Figures (1-4) (83) | Tables (1-1) (72) | Full Article (PDF)-3332K (76) | Full Article with Cover (PDF)-3660K (62) | Full Article (XML)-91K (47) | Audio-1073K (15) | Received: 08/30/2025 | Revised: 10/10/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (147) | Timeline of Article Publication (0) | Cite | (51) | (46) | (0) | (0) | (0) | (747) | (1) | Open

Basic Study

Dexmedetomidine enhances anastomotic healing partly via the Wnt/β-catenin pathway in a rat model of colon surgery

Ying Chen, Chun-Tian Li, Jie-Bo Wang, Wen-Lu Tang, Yu Zhao, Ye Chen, Lian-Ming Liao, Liang-Cheng Zhang, Tian-Hua Lin, Zhi-Fang Cao

World J Gastroenterol 31(44):112833. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112833

Abstract (110) | Core Tip (104) | Full Article (HTML) (504) | Figures (1-8) (80) | Tables (1-1) (78) | Full Article (PDF)-39135K (95) | Full Article with Cover (PDF)-39463K (66) | Full Article (XML)-121K (67) | Audio-293K (18) | Received: 08/06/2025 | Revised: 09/28/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (42) | Timeline of Article Publication (1) | Cite | (67) | (63) | (0) | (0) | (0) | (18) | (890) | Open

Case Report

Very-early-stage gastric amphicrine carcinoma with mixed histology: A case report and review of literature

Cai-Zhi Gao, Yuan Meng, Jin-Zhu Du, Xu Zhu

World J Gastroenterol 31(44):112187. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112187

Abstract (117) | Core Tip (105) | Full Article (HTML) (653) | Figures (1-6) (101) | Tables (1-1) (85) | Full Article (PDF)-30241K (116) | Full Article with Cover (PDF)-30570K (101) | Full Article (XML)-86K (48) | Audio-1338K (19) | Received: 07/29/2025 | Revised: 09/10/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (4701) | Timeline of Article Publication (5) | Cite | (49) | (56) | (0) | (0) | (0) | (22) | (1104) | (1) | Open

Letter to the Editor

Prudence is never excessive: Caution warranted in 5-aminosalicylic acid derivatives withdrawal for ulcerative colitis

Antonietta Gerarda Gravina, Raffaele Pellegrino, Alessandro Federico

World J Gastroenterol 31(44):113253. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113253

Abstract (116) | Core Tip (108) | Full Article (HTML) (553) | Full Article (PDF)-392K (84) | Full Article with Cover (PDF)-722K (167) | Full Article (XML)-48K (50) | Audio-244K (15) | Received: 08/19/2025 | Revised: 10/02/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (428) | Timeline of Article Publication (0) | Cite | (47) | (45) | (0) | (0) | (0) | (854) | Open

Risk elements and diagnostic indicators for asymptomatic immune checkpoint inhibitor-associated myocarditis in esophageal cancer

Tushar Bhadra, Brandon Lucke-Wold

World J Gastroenterol 31(44):113689. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113689

Abstract (125) | Core Tip (107) | Full Article (HTML) (402) | Full Article (PDF)-379K (80) | Full Article with Cover (PDF)-708K (49) | Full Article (XML)-39K (43) | Audio-6486K (31) | Received: 08/31/2025 | Revised: 09/25/2025 | Accepted: 10/16/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (184) | Timeline of Article Publication (0) | Cite | (62) | (59) | (0) | (0) | (0) | (20) | (574) | Open

Peroxiredoxin 1 inhibits tumorigenesis by activating the NLR family pyrin domain containing 3/gasdermin D pathway: Advanced therapies targeting heterogeneous cell death mechanisms

Anna Smirnova, Daria Eygel, Irina Kondrasheva, Denis S Baranovskii, Ilya D Klabukov

World J Gastroenterol 31(44):114404. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.114404

Abstract (134) | Core Tip (135) | Full Article (HTML) (402) | Full Article (PDF)-361K (66) | Full Article with Cover (PDF)-691K (65) | Full Article (XML)-39K (53) | Audio-62K (13) | Received: 09/17/2025 | Revised: 09/30/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (7) | Timeline of Article Publication (0) | Cite | (46) | (50) | (0) | (0) | (0) | (586) | Open

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