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Contents Volume 31 Issue 44 November 28, 2025

Editorial

Redefining therapeutic thresholds and global guidelines: Toward precision management of intermediate-sized rectal neuroendocrine tumors

Dan Hu, Jiang Yu, Meng-Xue Wang, Hao-Ling Zhang

World J Gastroenterol 31(44):114263. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.114263

Abstract (155) | Core Tip (148) | Full Article (HTML) (642) | Tables (1-1) (134) | Full Article (PDF)-398K (136) | Full Article with Cover (PDF)-726K (175) | Full Article (XML)-75K (61) | Audio-222K (14) | Received: 09/14/2025 | Revised: 10/10/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (3) | Cite | (61) | (51) | (0) | (0) | (0) | (22) | (2854) | (2) | Open

Review

Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway

Lie Zheng, Sheng-Lei Duan

World J Gastroenterol 31(44):109440. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.109440

Abstract (134) | Core Tip (130) | Full Article (HTML) (1121) | Figures (1-3) (93) | Full Article (PDF)-1729K (156) | Full Article with Cover (PDF)-2056K (245) | Full Article (XML)-231K (59) | Audio-209K (18) | Received: 05/10/2025 | Revised: 08/07/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (698) | Cite | (63) | (56) | (0) | (0) | (0) | (2) | (4311) | (4) | Open

Role of artificial intelligence in the detection and characterization of gastrointestinal premalignant and early malignant lesions

Noelle El Asmar, Mariam Baydoun, Jamil Mrad, Kassem Barada

World J Gastroenterol 31(44):111160. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.111160

Abstract (169) | Core Tip (187) | Full Article (HTML) (1246) | Figures (1-3) (88) | Tables (1-9) (87) | Full Article (PDF)-927K (262) | Full Article with Cover (PDF)-1252K (292) | Full Article (XML)-654K (54) | Audio-804K (20) | Received: 06/24/2025 | Revised: 07/20/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (392) | Cite | (59) | (72) | (0) | (0) | (0) | (4042) | (2) | Open

Application of traditional Chinese medicine integrated therapy based on Tuina and herbal medicine in pediatric diarrhea

Yu Zhu, Hai-Cheng Dong, Yao Zhang, Xiao-Ai Wang, Jun-Yi Chen, Jing-Jing Wang

World J Gastroenterol 31(44):113017. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113017

Abstract (151) | Core Tip (160) | Full Article (HTML) (1289) | Figures (1-2) (90) | Tables (1-2) (120) | Full Article (PDF)-792K (223) | Full Article with Cover (PDF)-1119K (155) | Full Article (XML)-237K (63) | Audio-247K (54) | Received: 08/19/2025 | Revised: 09/18/2025 | Accepted: 10/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (222) | Cite | (62) | (116) | (0) | (0) | (0) | (26) | (3839) | (3) | Open

Advances in the study of the relationship between neurotransmitters and gastric cancer

You-Zhao Liu, Wen-Xuan Liu, Wen-Hong Deng

World J Gastroenterol 31(44):113793. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113793

Abstract (163) | Core Tip (147) | Full Article (HTML) (918) | Figures (1-3) (123) | Tables (1-1) (112) | Full Article (PDF)-2218K (218) | Full Article with Cover (PDF)-2546K (101) | Full Article (XML)-323K (76) | Audio-561K (23) | Supplementary Material-666K (53) | Received: 09/03/2025 | Revised: 09/20/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (1367) | Cite | (63) | (76) | (0) | (0) | (0) | (33) | (4328) | (4) | Open

Case Control Study

Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma

Yan-Fei Feng, Tu-Mei Su, Bo-Bin Hu, Hang Wang, Qing-Mei Li, Qian-Bing Yin, Long Huang, Hong-Qian Liang, Ao-Li Ren, Ming-Hua Su, Jian-Ning Jiang

World J Gastroenterol 31(44):112481. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112481

Abstract (134) | Core Tip (137) | Full Article (HTML) (489) | Figures (1-6) (101) | Tables (1-5) (90) | Full Article (PDF)-1405K (85) | Full Article with Cover (PDF)-1734K (105) | Full Article (XML)-120K (55) | Audio-325K (18) | Received: 07/28/2025 | Revised: 09/13/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (2326) | Cite | (72) | (63) | (0) | (0) | (0) | (23) | (1) | (4302) | (3) | Open

Retrospective Cohort Study

Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B

Yan-Chao Fu, Jun Li, Jia-Yin Wang, Yi-Wen Zhang, Fei Yan, Jing Chen, Qin Du, Chao Yang, Jing Liang, Qing Ye, Hui-Ling Xiang

World J Gastroenterol 31(44):112719. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112719

Abstract (161) | Core Tip (144) | Full Article (HTML) (727) | Figures (1-5) (123) | Tables (1-2) (94) | Full Article (PDF)-1197K (120) | Full Article with Cover (PDF)-1526K (95) | Full Article (XML)-106K (56) | Audio-1375K (33) | Supplementary Material-116K (58) | Received: 08/04/2025 | Revised: 09/14/2025 | Accepted: 10/24/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (226) | Cite | (55) | (65) | (0) | (0) | (0) | (22) | (4789) | (2) | Open

Retrospective Study

DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles

Ismail Taskiran, Seda Orenay-Boyacioglu, Olcay Boyacioglu, Ibrahim Halil Erdogdu, Nil Culhaci, Ibrahim Meteoglu

World J Gastroenterol 31(44):112524. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112524

Abstract (136) | Core Tip (130) | Full Article (HTML) (764) | Figures (1-2) (84) | Tables (1-5) (109) | Full Article (PDF)-680K (114) | Full Article with Cover (PDF)-1008K (109) | Full Article (XML)-142K (59) | Audio-258K (16) | Received: 07/29/2025 | Revised: 09/13/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (1247) | Cite | (59) | (118) | (0) | (0) | (0) | (22) | (1) | (4128) | (4) | Open

Risk factors with nomogram construction for moderate to severe pain after endoscopic full-thickness resection

Guo-Yao Sun, Teng-Jiao Gao, Yong Sun, Wen Jia, Zhuo Yang

World J Gastroenterol 31(44):112576. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112576

Abstract (144) | Core Tip (150) | Full Article (HTML) (495) | Figures (1-2) (82) | Tables (1-2) (84) | Full Article (PDF)-701K (94) | Full Article with Cover (PDF)-1030K (117) | Full Article (XML)-71K (60) | Audio-1620K (10) | Received: 07/30/2025 | Revised: 09/06/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (371) | Cite | (55) | (55) | (0) | (0) | (0) | (2787) | (1) | Open

Clinical Trials Study

Influence of an internet-based proactive follow-up management model on the prognosis of nonalcoholic fatty liver disease

Sui-Yi Liu, Guo-Feng Gao, Xiao-Yu Wang, Jiao Yu

World J Gastroenterol 31(44):111731. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.111731

Abstract (132) | Core Tip (170) | Full Article (HTML) (518) | Tables (1-10) (89) | Full Article (PDF)-461K (105) | Full Article with Cover (PDF)-788K (80) | Full Article (XML)-94K (58) | Audio-1398K (11) | Received: 07/29/2025 | Revised: 09/14/2025 | Accepted: 10/28/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (310) | Cite | (62) | (69) | (0) | (0) | (0) | (3605) | (2) | Open

Randomized Controlled Trial

Covering the biopsy hole check valve with “enzymolysis gauze” reduces bacterial contamination in the endoscopy room

Hu-Bin Xia, Ying-Dong Hou, Yuan Zhang, Ai-Yu Yu, Qi Ding, Wen-Li Ruan, Yi-Shen Mao, Shu-Jiong Feng, Cong Ding, Yi-Feng Zhou

World J Gastroenterol 31(44):113650. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113650

Abstract (150) | Core Tip (129) | Full Article (HTML) (479) | Figures (1-4) (92) | Tables (1-1) (80) | Full Article (PDF)-3332K (86) | Full Article with Cover (PDF)-3660K (75) | Full Article (XML)-91K (54) | Audio-1073K (15) | Received: 08/30/2025 | Revised: 10/10/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (147) | Cite | (60) | (58) | (0) | (0) | (0) | (3032) | (1) | Open

Basic Study

Dexmedetomidine enhances anastomotic healing partly via the Wnt/β-catenin pathway in a rat model of colon surgery

Ying Chen, Chun-Tian Li, Jie-Bo Wang, Wen-Lu Tang, Yu Zhao, Ye Chen, Lian-Ming Liao, Liang-Cheng Zhang, Tian-Hua Lin, Zhi-Fang Cao

World J Gastroenterol 31(44):112833. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112833

Abstract (131) | Core Tip (120) | Full Article (HTML) (568) | Figures (1-8) (91) | Tables (1-1) (89) | Full Article (PDF)-39135K (111) | Full Article with Cover (PDF)-39463K (72) | Full Article (XML)-121K (76) | Audio-293K (18) | Received: 08/06/2025 | Revised: 09/28/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (42) | Cite | (77) | (71) | (0) | (0) | (0) | (25) | (2847) | Open

Case Report

Very-early-stage gastric amphicrine carcinoma with mixed histology: A case report and review of literature

Cai-Zhi Gao, Yuan Meng, Jin-Zhu Du, Xu Zhu

World J Gastroenterol 31(44):112187. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112187

Abstract (138) | Core Tip (120) | Full Article (HTML) (730) | Figures (1-6) (112) | Tables (1-1) (102) | Full Article (PDF)-30241K (125) | Full Article with Cover (PDF)-30570K (111) | Full Article (XML)-86K (56) | Audio-1338K (20) | Received: 07/29/2025 | Revised: 09/10/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (4721) | Cite | (58) | (64) | (0) | (0) | (0) | (30) | (3015) | (1) | Open

Letter to the Editor

Prudence is never excessive: Caution warranted in 5-aminosalicylic acid derivatives withdrawal for ulcerative colitis

Antonietta Gerarda Gravina, Raffaele Pellegrino, Alessandro Federico

World J Gastroenterol 31(44):113253. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113253

Abstract (137) | Core Tip (126) | Full Article (HTML) (634) | Full Article (PDF)-392K (98) | Full Article with Cover (PDF)-722K (186) | Full Article (XML)-48K (62) | Audio-244K (17) | Received: 08/19/2025 | Revised: 10/02/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (432) | Cite | (55) | (52) | (0) | (0) | (0) | (2927) | Open

Risk elements and diagnostic indicators for asymptomatic immune checkpoint inhibitor-associated myocarditis in esophageal cancer

Tushar Bhadra, Brandon Lucke-Wold

World J Gastroenterol 31(44):113689. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113689

Abstract (155) | Core Tip (131) | Full Article (HTML) (475) | Full Article (PDF)-379K (90) | Full Article with Cover (PDF)-708K (57) | Full Article (XML)-39K (50) | Audio-6486K (32) | Received: 08/31/2025 | Revised: 09/25/2025 | Accepted: 10/16/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (186) | Cite | (68) | (66) | (0) | (0) | (0) | (26) | (2329) | Open

Peroxiredoxin 1 inhibits tumorigenesis by activating the NLR family pyrin domain containing 3/gasdermin D pathway: Advanced therapies targeting heterogeneous cell death mechanisms

Anna Smirnova, Daria Eygel, Irina Kondrasheva, Denis S Baranovskii, Ilya D Klabukov

World J Gastroenterol 31(44):114404. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.114404

Abstract (160) | Core Tip (157) | Full Article (HTML) (464) | Full Article (PDF)-361K (74) | Full Article with Cover (PDF)-691K (81) | Full Article (XML)-39K (65) | Audio-62K (14) | Received: 09/17/2025 | Revised: 09/30/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (7) | Cite | (55) | (58) | (0) | (0) | (0) | (2404) | Open

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