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Contents Volume 31 Issue 44 November 28, 2025

Editorial

Redefining therapeutic thresholds and global guidelines: Toward precision management of intermediate-sized rectal neuroendocrine tumors

Dan Hu, Jiang Yu, Meng-Xue Wang, Hao-Ling Zhang

World J Gastroenterol 31(44):114263. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.114263

Abstract (79) | Core Tip (64) | Full Article (HTML) (312) | Tables (1-1) (55) | Full Article (PDF)-398K (98) | Full Article with Cover (PDF)-726K (116) | Full Article (XML)-75K (31) | Audio-222K (9) | Received: 09/14/2025 | Revised: 10/10/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (3) | Timeline of Article Publication (4) | Cite | (22) | (22) | (0) | (0) | (0) | (2) | (612) | (1) | Open

Review

Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway

Lie Zheng, Sheng-Lei Duan

World J Gastroenterol 31(44):109440. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.109440

Abstract (59) | Core Tip (63) | Full Article (HTML) (524) | Figures (1-3) (47) | Full Article (PDF)-1729K (114) | Full Article with Cover (PDF)-2056K (171) | Full Article (XML)-231K (29) | Audio-209K (13) | Received: 05/10/2025 | Revised: 08/07/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (669) | Timeline of Article Publication (2) | Cite | (31) | (30) | (0) | (0) | (0) | (2) | (885) | (1) | Open

Role of artificial intelligence in the detection and characterization of gastrointestinal premalignant and early malignant lesions

Kassem Barada, Jamil Mrad, Mariam Baydoun, Noelle El Asmar

World J Gastroenterol 31(44):111160. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.111160

Abstract (74) | Core Tip (90) | Full Article (HTML) (602) | Figures (1-3) (48) | Tables (1-9) (44) | Full Article (PDF)-927K (216) | Full Article with Cover (PDF)-1252K (236) | Full Article (XML)-654K (26) | Audio-804K (8) | Received: 06/24/2025 | Revised: 07/20/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (327) | Timeline of Article Publication (1) | Cite | (26) | (39) | (0) | (0) | (0) | (1172) | Open

Application of traditional Chinese medicine integrated therapy based on Tuina and herbal medicine in pediatric diarrhea

Yu Zhu, Hai-Cheng Dong, Yao Zhang, Xiao-Ai Wang, Jun-Yi Chen, Jing-Jing Wang

World J Gastroenterol 31(44):113017. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113017

Abstract (77) | Core Tip (63) | Full Article (HTML) (600) | Figures (1-2) (45) | Tables (1-2) (67) | Full Article (PDF)-792K (174) | Full Article with Cover (PDF)-1119K (111) | Full Article (XML)-237K (29) | Audio-247K (26) | Received: 08/19/2025 | Revised: 09/18/2025 | Accepted: 10/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (210) | Timeline of Article Publication (2) | Cite | (29) | (65) | (0) | (0) | (0) | (4) | (1026) | (1) | Open

Advances in the study of the relationship between neurotransmitters and gastric cancer

You-Zhao Liu, Wen-Xuan Liu, Wen-Hong Deng

World J Gastroenterol 31(44):113793. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113793

Abstract (68) | Core Tip (63) | Full Article (HTML) (407) | Figures (1-3) (55) | Tables (1-1) (51) | Full Article (PDF)-2218K (156) | Full Article with Cover (PDF)-2546K (65) | Full Article (XML)-323K (38) | Audio-561K (9) | Supplementary Material-666K (27) | Received: 09/03/2025 | Revised: 09/20/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (1302) | Timeline of Article Publication (5) | Cite | (27) | (39) | (0) | (0) | (0) | (2) | (772) | Open

Case Control Study

Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma

Yan-Fei Feng, Tu-Mei Su, Bo-Bin Hu, Hang Wang, Qing-Mei Li, Qian-Bing Yin, Long Huang, Hong-Qian Liang, Ao-Li Ren, Ming-Hua Su, Jian-Ning Jiang

World J Gastroenterol 31(44):112481. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112481

Abstract (61) | Core Tip (61) | Full Article (HTML) (221) | Figures (1-6) (47) | Tables (1-5) (48) | Full Article (PDF)-1405K (52) | Full Article with Cover (PDF)-1734K (56) | Full Article (XML)-120K (25) | Audio-325K (11) | Received: 07/28/2025 | Revised: 09/13/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (2252) | Timeline of Article Publication (1) | Cite | (25) | (30) | (0) | (0) | (0) | (3) | (449) | (1) | Open

Retrospective Cohort Study

Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B

Yan-Chao Fu, Jun Li, Jia-Yin Wang, Yi-Wen Zhang, Fei Yan, Jing Chen, Qin Du, Chao Yang, Jing Liang, Qing Ye, Hui-Ling Xiang

World J Gastroenterol 31(44):112719. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112719

Abstract (76) | Core Tip (65) | Full Article (HTML) (376) | Figures (1-5) (78) | Tables (1-2) (50) | Full Article (PDF)-1197K (70) | Full Article with Cover (PDF)-1526K (54) | Full Article (XML)-106K (26) | Audio-1375K (27) | Supplementary Material-116K (30) | Received: 08/04/2025 | Revised: 09/14/2025 | Accepted: 10/24/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (207) | Timeline of Article Publication (0) | Cite | (28) | (34) | (0) | (0) | (0) | (3) | (654) | Open

Retrospective Study

DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles

Ismail Taskiran, Seda Orenay-Boyacioglu, Olcay Boyacioglu, Ibrahim Halil Erdogdu, Nil Culhaci, Ibrahim Meteoglu

World J Gastroenterol 31(44):112524. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112524

Abstract (63) | Core Tip (56) | Full Article (HTML) (379) | Figures (1-2) (43) | Tables (1-5) (62) | Full Article (PDF)-680K (61) | Full Article with Cover (PDF)-1008K (62) | Full Article (XML)-142K (27) | Audio-258K (8) | Received: 07/29/2025 | Revised: 09/13/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (1182) | Timeline of Article Publication (2) | Cite | (29) | (76) | (0) | (0) | (0) | (4) | (634) | (1) | Open

Risk factors with nomogram construction for moderate to severe pain after endoscopic full-thickness resection

Guo-Yao Sun, Teng-Jiao Gao, Yong Sun, Wen Jia, Zhuo Yang

World J Gastroenterol 31(44):112576. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112576

Abstract (68) | Core Tip (68) | Full Article (HTML) (250) | Figures (1-2) (46) | Tables (1-2) (44) | Full Article (PDF)-701K (51) | Full Article with Cover (PDF)-1030K (75) | Full Article (XML)-71K (29) | Audio-1620K (7) | Received: 07/30/2025 | Revised: 09/06/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (343) | Timeline of Article Publication (0) | Cite | (24) | (21) | (0) | (0) | (0) | (495) | Open

Clinical Trials Study

Influence of an internet-based proactive follow-up management model on the prognosis of nonalcoholic fatty liver disease

Sui-Yi Liu, Guo-Feng Gao, Xiao-Yu Wang, Jiao Yu

World J Gastroenterol 31(44):111731. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.111731

Abstract (61) | Core Tip (89) | Full Article (HTML) (255) | Tables (1-10) (48) | Full Article (PDF)-461K (60) | Full Article with Cover (PDF)-788K (35) | Full Article (XML)-94K (27) | Audio-1398K (9) | Received: 07/29/2025 | Revised: 09/14/2025 | Accepted: 10/28/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (300) | Timeline of Article Publication (0) | Cite | (25) | (27) | (0) | (0) | (0) | (425) | (1) | Open

Randomized Controlled Trial

Covering the biopsy hole check valve with “enzymolysis gauze” reduces bacterial contamination in the endoscopy room

Hu-Bin Xia, Ying-Dong Hou, Yuan Zhang, Ai-Yu Yu, Qi Ding, Wen-Li Ruan, Yi-Shen Mao, Shu-Jiong Feng, Cong Ding, Yi-Feng Zhou

World J Gastroenterol 31(44):113650. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113650

Abstract (64) | Core Tip (54) | Full Article (HTML) (205) | Figures (1-4) (52) | Tables (1-1) (46) | Full Article (PDF)-3332K (44) | Full Article with Cover (PDF)-3660K (44) | Full Article (XML)-91K (26) | Audio-1073K (9) | Received: 08/30/2025 | Revised: 10/10/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (144) | Timeline of Article Publication (0) | Cite | (28) | (28) | (0) | (0) | (0) | (417) | Open

Basic Study

Dexmedetomidine enhances anastomotic healing partly via the Wnt/β-catenin pathway in a rat model of colon surgery

Ying Chen, Chun-Tian Li, Jie-Bo Wang, Wen-Lu Tang, Yu Zhao, Ye Chen, Lian-Ming Liao, Liang-Cheng Zhang, Tian-Hua Lin, Zhi-Fang Cao

World J Gastroenterol 31(44):112833. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112833

Abstract (56) | Core Tip (53) | Full Article (HTML) (310) | Figures (1-8) (51) | Tables (1-1) (48) | Full Article (PDF)-39135K (67) | Full Article with Cover (PDF)-39463K (50) | Full Article (XML)-121K (46) | Audio-293K (12) | Received: 08/06/2025 | Revised: 09/28/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (40) | Timeline of Article Publication (1) | Cite | (34) | (39) | (0) | (0) | (0) | (3) | (572) | Open

Case Report

Very-early-stage gastric amphicrine carcinoma with mixed histology: A case report and review of literature

Cai-Zhi Gao, Yuan Meng, Jin-Zhu Du, Xu Zhu

World J Gastroenterol 31(44):112187. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112187

Abstract (64) | Core Tip (56) | Full Article (HTML) (338) | Figures (1-6) (65) | Tables (1-1) (48) | Full Article (PDF)-30241K (85) | Full Article with Cover (PDF)-30570K (76) | Full Article (XML)-86K (24) | Audio-1338K (9) | Received: 07/29/2025 | Revised: 09/10/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (4568) | Timeline of Article Publication (4) | Cite | (27) | (35) | (0) | (0) | (0) | (5) | (636) | Open

Letter to the Editor

Prudence is never excessive: Caution warranted in 5-aminosalicylic acid derivatives withdrawal for ulcerative colitis

Antonietta Gerarda Gravina, Raffaele Pellegrino, Alessandro Federico

World J Gastroenterol 31(44):113253. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113253

Abstract (66) | Core Tip (62) | Full Article (HTML) (355) | Full Article (PDF)-392K (68) | Full Article with Cover (PDF)-722K (123) | Full Article (XML)-48K (29) | Audio-244K (10) | Received: 08/19/2025 | Revised: 10/02/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (417) | Timeline of Article Publication (0) | Cite | (26) | (27) | (0) | (0) | (0) | (575) | Open

Risk elements and diagnostic indicators for asymptomatic immune checkpoint inhibitor-associated myocarditis in esophageal cancer

Tushar Bhadra, Brandon Lucke-Wold

World J Gastroenterol 31(44):113689. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113689

Abstract (75) | Core Tip (53) | Full Article (HTML) (217) | Full Article (PDF)-379K (55) | Full Article with Cover (PDF)-708K (31) | Full Article (XML)-39K (25) | Audio-6486K (22) | Received: 08/31/2025 | Revised: 09/25/2025 | Accepted: 10/16/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (179) | Timeline of Article Publication (0) | Cite | (33) | (27) | (0) | (0) | (0) | (3) | (328) | Open

Peroxiredoxin 1 inhibits tumorigenesis by activating the NLR family pyrin domain containing 3/gasdermin D pathway: Advanced therapies targeting heterogeneous cell death mechanisms

Anna Smirnova, Daria Eygel, Irina Kondrasheva, Denis S Baranovskii, Ilya D Klabukov

World J Gastroenterol 31(44):114404. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.114404

Abstract (68) | Core Tip (63) | Full Article (HTML) (215) | Full Article (PDF)-361K (48) | Full Article with Cover (PDF)-691K (47) | Full Article (XML)-39K (31) | Audio-62K (6) | Received: 09/17/2025 | Revised: 09/30/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (6) | Timeline of Article Publication (0) | Cite | (26) | (29) | (0) | (0) | (0) | (341) | Open

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