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Contents Volume 31 Issue 44 November 28, 2025

Editorial

Redefining therapeutic thresholds and global guidelines: Toward precision management of intermediate-sized rectal neuroendocrine tumors

Dan Hu, Jiang Yu, Meng-Xue Wang, Hao-Ling Zhang

World J Gastroenterol 31(44):114263. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.114263

Abstract (95) | Core Tip (82) | Full Article (HTML) (352) | Tables (1-1) (73) | Full Article (PDF)-398K (109) | Full Article with Cover (PDF)-726K (125) | Full Article (XML)-75K (41) | Audio-222K (10) | Received: 09/14/2025 | Revised: 10/10/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (3) | Timeline of Article Publication (4) | Cite | (32) | (32) | (0) | (0) | (0) | (8) | (700) | (2) | Open

Review

Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway

Lie Zheng, Sheng-Lei Duan

World J Gastroenterol 31(44):109440. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.109440

Abstract (74) | Core Tip (77) | Full Article (HTML) (635) | Figures (1-3) (57) | Full Article (PDF)-1729K (127) | Full Article with Cover (PDF)-2056K (187) | Full Article (XML)-231K (34) | Audio-209K (15) | Received: 05/10/2025 | Revised: 08/07/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (674) | Timeline of Article Publication (2) | Cite | (39) | (37) | (0) | (0) | (0) | (2) | (1040) | (2) | Open

Role of artificial intelligence in the detection and characterization of gastrointestinal premalignant and early malignant lesions

Noelle El Asmar, Mariam Baydoun, Jamil Mrad, Kassem Barada

World J Gastroenterol 31(44):111160. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.111160

Abstract (90) | Core Tip (110) | Full Article (HTML) (705) | Figures (1-3) (55) | Tables (1-9) (55) | Full Article (PDF)-927K (227) | Full Article with Cover (PDF)-1252K (251) | Full Article (XML)-654K (32) | Audio-804K (17) | Received: 06/24/2025 | Revised: 07/20/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (337) | Timeline of Article Publication (1) | Cite | (31) | (46) | (0) | (0) | (0) | (1325) | (1) | Open

Application of traditional Chinese medicine integrated therapy based on Tuina and herbal medicine in pediatric diarrhea

Yu Zhu, Hai-Cheng Dong, Yao Zhang, Xiao-Ai Wang, Jun-Yi Chen, Jing-Jing Wang

World J Gastroenterol 31(44):113017. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113017

Abstract (93) | Core Tip (92) | Full Article (HTML) (737) | Figures (1-2) (58) | Tables (1-2) (79) | Full Article (PDF)-792K (191) | Full Article with Cover (PDF)-1119K (117) | Full Article (XML)-237K (34) | Audio-247K (32) | Received: 08/19/2025 | Revised: 09/18/2025 | Accepted: 10/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (214) | Timeline of Article Publication (4) | Cite | (37) | (78) | (0) | (0) | (0) | (11) | (1216) | (3) | Open

Advances in the study of the relationship between neurotransmitters and gastric cancer

You-Zhao Liu, Wen-Xuan Liu, Wen-Hong Deng

World J Gastroenterol 31(44):113793. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113793

Abstract (88) | Core Tip (77) | Full Article (HTML) (491) | Figures (1-3) (72) | Tables (1-1) (63) | Full Article (PDF)-2218K (175) | Full Article with Cover (PDF)-2546K (70) | Full Article (XML)-323K (45) | Audio-561K (11) | Supplementary Material-666K (33) | Received: 09/03/2025 | Revised: 09/20/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (1320) | Timeline of Article Publication (5) | Cite | (34) | (46) | (0) | (0) | (0) | (8) | (916) | (3) | Open

Case Control Study

Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma

Yan-Fei Feng, Tu-Mei Su, Bo-Bin Hu, Hang Wang, Qing-Mei Li, Qian-Bing Yin, Long Huang, Hong-Qian Liang, Ao-Li Ren, Ming-Hua Su, Jian-Ning Jiang

World J Gastroenterol 31(44):112481. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112481

Abstract (74) | Core Tip (82) | Full Article (HTML) (273) | Figures (1-6) (57) | Tables (1-5) (58) | Full Article (PDF)-1405K (61) | Full Article with Cover (PDF)-1734K (69) | Full Article (XML)-120K (33) | Audio-325K (14) | Received: 07/28/2025 | Revised: 09/13/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (2275) | Timeline of Article Publication (4) | Cite | (37) | (38) | (0) | (0) | (0) | (8) | (1) | (551) | (2) | Open

Retrospective Cohort Study

Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B

Yan-Chao Fu, Jun Li, Jia-Yin Wang, Yi-Wen Zhang, Fei Yan, Jing Chen, Qin Du, Chao Yang, Jing Liang, Qing Ye, Hui-Ling Xiang

World J Gastroenterol 31(44):112719. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112719

Abstract (94) | Core Tip (85) | Full Article (HTML) (422) | Figures (1-5) (88) | Tables (1-2) (58) | Full Article (PDF)-1197K (80) | Full Article with Cover (PDF)-1526K (62) | Full Article (XML)-106K (32) | Audio-1375K (31) | Supplementary Material-116K (36) | Received: 08/04/2025 | Revised: 09/14/2025 | Accepted: 10/24/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (214) | Timeline of Article Publication (0) | Cite | (34) | (43) | (0) | (0) | (0) | (9) | (742) | Open

Retrospective Study

DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles

Ismail Taskiran, Seda Orenay-Boyacioglu, Olcay Boyacioglu, Ibrahim Halil Erdogdu, Nil Culhaci, Ibrahim Meteoglu

World J Gastroenterol 31(44):112524. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112524

Abstract (82) | Core Tip (72) | Full Article (HTML) (453) | Figures (1-2) (51) | Tables (1-5) (72) | Full Article (PDF)-680K (71) | Full Article with Cover (PDF)-1008K (70) | Full Article (XML)-142K (35) | Audio-258K (12) | Received: 07/29/2025 | Revised: 09/13/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (1195) | Timeline of Article Publication (2) | Cite | (36) | (90) | (0) | (0) | (0) | (10) | (1) | (752) | (2) | Open

Risk factors with nomogram construction for moderate to severe pain after endoscopic full-thickness resection

Guo-Yao Sun, Teng-Jiao Gao, Yong Sun, Wen Jia, Zhuo Yang

World J Gastroenterol 31(44):112576. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112576

Abstract (89) | Core Tip (90) | Full Article (HTML) (277) | Figures (1-2) (52) | Tables (1-2) (51) | Full Article (PDF)-701K (61) | Full Article with Cover (PDF)-1030K (84) | Full Article (XML)-71K (36) | Audio-1620K (8) | Received: 07/30/2025 | Revised: 09/06/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (354) | Timeline of Article Publication (0) | Cite | (32) | (31) | (0) | (0) | (0) | (561) | Open

Clinical Trials Study

Influence of an internet-based proactive follow-up management model on the prognosis of nonalcoholic fatty liver disease

Sui-Yi Liu, Guo-Feng Gao, Xiao-Yu Wang, Jiao Yu

World J Gastroenterol 31(44):111731. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.111731

Abstract (80) | Core Tip (109) | Full Article (HTML) (290) | Tables (1-10) (56) | Full Article (PDF)-461K (73) | Full Article with Cover (PDF)-788K (43) | Full Article (XML)-94K (33) | Audio-1398K (10) | Received: 07/29/2025 | Revised: 09/14/2025 | Accepted: 10/28/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (304) | Timeline of Article Publication (0) | Cite | (33) | (34) | (0) | (0) | (0) | (495) | (1) | Open

Randomized Controlled Trial

Covering the biopsy hole check valve with “enzymolysis gauze” reduces bacterial contamination in the endoscopy room

Hu-Bin Xia, Ying-Dong Hou, Yuan Zhang, Ai-Yu Yu, Qi Ding, Wen-Li Ruan, Yi-Shen Mao, Shu-Jiong Feng, Cong Ding, Yi-Feng Zhou

World J Gastroenterol 31(44):113650. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113650

Abstract (84) | Core Tip (76) | Full Article (HTML) (238) | Figures (1-4) (60) | Tables (1-1) (54) | Full Article (PDF)-3332K (51) | Full Article with Cover (PDF)-3660K (48) | Full Article (XML)-91K (33) | Audio-1073K (13) | Received: 08/30/2025 | Revised: 10/10/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (145) | Timeline of Article Publication (0) | Cite | (33) | (34) | (0) | (0) | (0) | (484) | Open

Basic Study

Dexmedetomidine enhances anastomotic healing partly via the Wnt/β-catenin pathway in a rat model of colon surgery

Ying Chen, Chun-Tian Li, Jie-Bo Wang, Wen-Lu Tang, Yu Zhao, Ye Chen, Lian-Ming Liao, Liang-Cheng Zhang, Tian-Hua Lin, Zhi-Fang Cao

World J Gastroenterol 31(44):112833. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112833

Abstract (76) | Core Tip (74) | Full Article (HTML) (346) | Figures (1-8) (57) | Tables (1-1) (58) | Full Article (PDF)-39135K (73) | Full Article with Cover (PDF)-39463K (55) | Full Article (XML)-121K (52) | Audio-293K (16) | Received: 08/06/2025 | Revised: 09/28/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (40) | Timeline of Article Publication (1) | Cite | (40) | (43) | (0) | (0) | (0) | (10) | (641) | Open

Case Report

Very-early-stage gastric amphicrine carcinoma with mixed histology: A case report and review of literature

Cai-Zhi Gao, Yuan Meng, Jin-Zhu Du, Xu Zhu

World J Gastroenterol 31(44):112187. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112187

Abstract (84) | Core Tip (72) | Full Article (HTML) (414) | Figures (1-6) (79) | Tables (1-1) (60) | Full Article (PDF)-30241K (97) | Full Article with Cover (PDF)-30570K (88) | Full Article (XML)-86K (35) | Audio-1338K (16) | Received: 07/29/2025 | Revised: 09/10/2025 | Accepted: 10/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (4609) | Timeline of Article Publication (5) | Cite | (36) | (44) | (0) | (0) | (0) | (12) | (773) | Open

Letter to the Editor

Prudence is never excessive: Caution warranted in 5-aminosalicylic acid derivatives withdrawal for ulcerative colitis

Antonietta Gerarda Gravina, Raffaele Pellegrino, Alessandro Federico

World J Gastroenterol 31(44):113253. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113253

Abstract (82) | Core Tip (80) | Full Article (HTML) (395) | Full Article (PDF)-392K (76) | Full Article with Cover (PDF)-722K (155) | Full Article (XML)-48K (36) | Audio-244K (13) | Received: 08/19/2025 | Revised: 10/02/2025 | Accepted: 10/23/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (420) | Timeline of Article Publication (0) | Cite | (33) | (35) | (0) | (0) | (0) | (662) | Open

Risk elements and diagnostic indicators for asymptomatic immune checkpoint inhibitor-associated myocarditis in esophageal cancer

Tushar Bhadra, Brandon Lucke-Wold

World J Gastroenterol 31(44):113689. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113689

Abstract (91) | Core Tip (71) | Full Article (HTML) (247) | Full Article (PDF)-379K (61) | Full Article with Cover (PDF)-708K (35) | Full Article (XML)-39K (31) | Audio-6486K (24) | Received: 08/31/2025 | Revised: 09/25/2025 | Accepted: 10/16/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (181) | Timeline of Article Publication (0) | Cite | (39) | (32) | (0) | (0) | (0) | (8) | (374) | Open

Peroxiredoxin 1 inhibits tumorigenesis by activating the NLR family pyrin domain containing 3/gasdermin D pathway: Advanced therapies targeting heterogeneous cell death mechanisms

Anna Smirnova, Daria Eygel, Irina Kondrasheva, Denis S Baranovskii, Ilya D Klabukov

World J Gastroenterol 31(44):114404. Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.114404

Abstract (83) | Core Tip (83) | Full Article (HTML) (251) | Full Article (PDF)-361K (55) | Full Article with Cover (PDF)-691K (53) | Full Article (XML)-39K (40) | Audio-62K (10) | Received: 09/17/2025 | Revised: 09/30/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Similar Articles (6) | Timeline of Article Publication (0) | Cite | (34) | (36) | (0) | (0) | (0) | (399) | Open

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