Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2025; 31(44): 114263
Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.114263
Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.114263
Redefining therapeutic thresholds and global guidelines: Toward precision management of intermediate-sized rectal neuroendocrine tumors
Dan Hu, Department of Nursing, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China
Jiang Yu, Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Meng-Xue Wang, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Hao-Ling Zhang, Department of Biomedical Science, Universiti Sains Malaysia, Pinang 13200, Malaysia
Co-first authors: Dan Hu and Jiang Yu.
Co-corresponding authors: Meng-Xue Wang and Hao-Ling Zhang.
Author contributions: Hu D and Yu J were responsible for study conception, literature review, and drafting of the manuscript as co-first authors; Wang MX and Zhang HL provided critical revisions and supervised the overall direction of the project as co-corresponding authors; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest related to this manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Meng-Xue Wang, PhD, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, Yuzhong District, Chongqing 400010, China. 306419@hospital.cqmu.edu.cn
Received: September 15, 2025
Revised: October 10, 2025
Accepted: October 22, 2025
Published online: November 28, 2025
Processing time: 74 Days and 11.9 Hours
Revised: October 10, 2025
Accepted: October 22, 2025
Published online: November 28, 2025
Processing time: 74 Days and 11.9 Hours
Core Tip
Core Tip: The management strategy for medium-sized rectal neuroendocrine tumors (rNETs) remains a subject of debate. Inspired by the latest research by Kim et al, this editorial summarizes the differences in international guidelines regarding management strategies, recent advances in endoscopic resection techniques, and their oncological safety. This editorial posits that, for medium-sized rNETs, endoscopic resection is emerging as a highly promising therapeutic option due to its minimally invasive nature, lower incidence of postoperative complications, and greater cost and time effectiveness.