Very-early-stage gastric amphicrine carcinoma with mixed histology: A case report and review of literature

Table 1 Clinicopathological features of recently reported cases of gastric amphicrine carcinoma

Ref.	Age/sex	Tumor location	Size/stage	Histological components & growth pattern	IHC findings	Treatment	Outcome/follow-up
Current case	59/male	Gastric body	1.5 cm/T1b (SM)	Poorly differentiated adenocarcinoma, NET, SRCC	Syn (+), CgA (+)	ESD only	Alive, no recurrence at 6 months
Huang et al[17], 2019	61-69/male (10 cases)	Stomach (8), intestine (2)	2-5.5 cm/T1-T4	Tubular, fusion, or single-file growth of goblet/SRCC-like cells. Mixed with adenoma or NEC in 4 cases	Syn (+), CgA (+)	Surgery +/- chemo/radio	3/10 DOD. High-grade worse prognosis
Hanamatsu et al[18], 2019	60/female	Gastric corpus	5.0 cm/T4aN2	Poorly cohesive carcinoma with SRCC	Syn (+), CgA (+), CD56 (+)	Total gastrectomy	Not specified
Qian and Feng[21], 2022	69/male	Gastric body/antrum	8.5 cm/T4aN3b (stage IIIC)	Tubular, solid nests, cribriform, single-file patterns	Syn (+), CgA (-)	Surgery + chemotherapy (adenocarcinoma regimen)	Alive, no recurrence at 6 months
Sciarra et al[22], 2023	63/male	Gastric cardia	1.2 cm/T1b (SM)	Nests, trabeculae, acinar structures. Pancreatic acinar differentiation	Syn (+), CgA (+), trypsin (+), BCL10 (+)	Wedge resection	Alive, no recurrence at 18 months
Ebedes et al[3], 2024	55/female	Gastric body (lesser curvature)	2.6 cm/T2 (MP)	Nested and glandular patterns with intracytoplasmic mucin	Syn (+), CgA (+)	Total gastrectomy	Not specified

IHC: Immunohistochemistry; SM: Invasion into submucosa; NET: Neuroendocrine tumor; SRCC: Signet-ring cell carcinoma; Syn: Synaptophysin; CgA: Chromogranin A; ESD: Endoscopic submucosal dissection; NEC: Neuroendocrine carcinoma; DOD: Died of disease; MP: Invasion into muscularis propria.