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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2025; 31(44): 112187
Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112187
Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112187
Very-early-stage gastric amphicrine carcinoma with mixed histology: A case report and review of literature
Cai-Zhi Gao, Xu Zhu, Department of Endoscopy, Fushun Central Hospital, Fushun 113006, Liaoning Province, China
Yuan Meng, Department of Pathology, Fushun Central Hospital, Fushun 113006, Liaoning Province, China
Jin-Zhu Du, Department of General Surgery, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
Co-corresponding authors: Jin-Zhu Du and Xu Zhu.
Author contributions: Gao CZ contributed to the manuscript writing and editing, and data collection; Meng Y contributed to conceptualization and supervision; Du JZ and Zhu X contributed equally to revising the article and supervision, and they are co-corresponding authors of this manuscript. All authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xu Zhu, Department of Endoscopy, Fushun Central Hospital, No. 5 Xincheng Road, Shuncheng District, Fushun 113006, Liaoning Province, China.
Received: July 30, 2025
Revised: September 10, 2025
Accepted: October 20, 2025
Published online: November 28, 2025
Processing time: 125 Days and 11.2 Hours
Revised: September 10, 2025
Accepted: October 20, 2025
Published online: November 28, 2025
Processing time: 125 Days and 11.2 Hours
Core Tip
Core Tip: Based on white-light endoscopy findings and biopsy pathology results, this case was initially diagnosed as pure signet-ring cell carcinoma. Subsequent narrow-band imaging magnifying endoscopy supported this diagnosis. However, post-endoscopic submucosal dissection pathology revealed a very-early-stage amphicrine carcinoma with a mixed growth pattern comprising poorly differentiated adenocarcinoma, neuroendocrine tumor, and signet-ring cell carcinoma. We subsequently re-evaluated the endoscopic manifestations of this lesion and, in conjunction with the pathological findings, proposed the endoscopic features of amphicrine carcinoma presenting with signet-ring cell morphology.