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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2025; 31(44): 113017
Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113017
Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.113017
Application of traditional Chinese medicine integrated therapy based on Tuina and herbal medicine in pediatric diarrhea
Yu Zhu, Hai-Cheng Dong, Yao Zhang, Xiao-Ai Wang, Department of Traditional Chinese Medicine, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310003, Zhejiang Province, China
Jun-Yi Chen, Jing-Jing Wang, Department of Nephrology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310003, Zhejiang Province, China
Author contributions: Zhu Y, Dong HC, Zhang Y and Wang XA designed the experiments and conducted clinical data collection; Chen JY and Wang JJ performed postoperative follow-up and recorded the data, conducted the collation and statistical analysis; Zhu Y make critical revisions to important knowledge content; all authors read and approved the final manuscript.
Supported by the Key Research and Development Program of Zhejiang Province, No. 2024C03211; and the Traditional Chinese Medicine Science and Technology Plan Project of Zhejiang Province, No. 2023ZL498.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu Zhu, MD, Doctor, Department of Traditional Chinese Medicine, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 57 Zhugan Lane, Wulin Street, Gongshu District, Hangzhou 310003, Zhejiang Province, China. 6504036@zju.edu.cn
Received: August 19, 2025
Revised: September 18, 2025
Accepted: October 21, 2025
Published online: November 28, 2025
Processing time: 100 Days and 19.4 Hours
Revised: September 18, 2025
Accepted: October 21, 2025
Published online: November 28, 2025
Processing time: 100 Days and 19.4 Hours
Core Tip
Core Tip: This review elucidates the distinct mechanisms by which integrated traditional Chinese medicine therapies Tuina massage and topical herbal medicine ameliorate pediatric diarrhea. We highlight that Tuina primarily modulates neuro-immune pathways to regulate motility and inflammation, while herbal applications directly restore intestinal barrier integrity and reprogram enterocyte metabolism. Crucially, this work synthesizes evidence for their synergistic action in repairing the gut barrier, a core pathophysiological defect, providing a mechanistic foundation for non-pharmacological, holistic complementary strategies in children.