Pancreatic steatosis is not associated with advanced steatohepatitis or fibrosis in metabolic dysfunction-associated steatotic liver disease

Figure 1 Flow chart of study design and inclusion criteria. NAFPD: Non-alcoholic fatty pancreas disease; MASLD: Metabolic dysfunction-associated steatotic liver disease; MASH: Metabolic dysfunction-associated steatohepatitis; CT: Computed tomography.

Figure 2 Relationship between pancreatic and hepatic steatosis. A: Scatterplot for pancreatic steatosis by hepatic steatosis on computed tomography (n = 99), Pearson correlation test, r = 0.04, P = 0.71; B: Scatterplot for pancreatic steatosis by percent hepatic steatosis on biopsy (n = 99), Spearman correlation test, r = -0.12, P = 0.29; C: Box and whiskers plot with all values included for pancreatic steatosis by steatosis grade on biopsy (n = 11 for grade 0, n = 33 for grade 1, n = 35 for grade 2, n = 20 for grade 3), Kruskal-Wallis test, P = 0.54.

Figure 3 Relationship between pancreatic steatosis and metabolic dysfunction-associated steatohepatitis grade and fibrosis stage. A: Box and whiskers plot with all values included for pancreatic steatosis by metabolic dysfunction-associated steatohepatitis grade on biopsy (n = 22 for grade 0, n = 66 for grade 1, n = 11 for grade 2 and 3), Kruskal-Wallis test, P = 0.99; B: Box and whiskers plot with all values included for pancreatic steatosis by fibrosis stage on biopsy (n = 15 for stage 0, n = 20 for stage 1, n = 16 for stage 2, n = 10 for stage 3, n = 38 for stage 4), Kruskal-Wallis test, P = 0.98; C: Box and whiskers plot with all values included for pancreatic steatosis by fibrosis category [minimal 0 to 2 (n = 51) vs advanced 3 to 4 (n = 48)] on biopsy, Wilcoxon test, P > 0.99. MASH: Metabolic dysfunction-associated steatohepatitis.

Figure 4 Relationship between pancreatic and hepatic steatosis after exclusion of patients with ‘burnt-out steatohepatitis’. A: Scatterplot for pancreatic steatosis by hepatic steatosis on computed tomography (n = 87), Pearson correlation test, r = 0.05, P = 0.62; B: Scatterplot for pancreatic steatosis by percent hepatic steatosis on biopsy (n = 87), Spearman correlation test, r = -0.06, P = 0.29; C: Box and whiskers plot with all values included for pancreatic steatosis by steatosis grade on biopsy (n = 3 for grade 0, n = 29 for grade 1, n = 35 for grade 2, n = 20 for grade 3), Kruskal-Wallis test, P = 0.79.